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Biology and Biochemistry

D-Index
80
Citations
30591
World Ranking
4008
National Ranking
1979

Overview

Guo-Cheng Yuan is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research focuses primarily on Biochemistry, Genetics, and Molecular Biology, with extensive work in Molecular Biology, Immunology, Biophysics, Genetics, and Oncology.

The scientist's research topics cover a broad range of areas, including:

  • Single-cell and spatial transcriptomics
  • Genomics and chromatin dynamics
  • RNA research and splicing
  • Gene expression and cancer classification
  • Bioinformatics and genomic networks
  • Cell image analysis techniques
  • Neuroinflammation and neurodegeneration mechanisms

Guo-Cheng Yuan has published multiple recent papers, such as:

  • "Giotto: a toolbox for integrative analysis and visualization of spatial expression data" (2021, Genome Biology)
  • "Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy" (2020, Cell)
  • "Integrated spatial genomics reveals global architecture of single nuclei" (2021, Nature)
  • "Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient" (2020, Cell Stem Cell)
  • "SpatialDWLS: accurate deconvolution of spatial transcriptomic data" (2021, Genome Biology)

Their frequent co-authors include Stuart H. Orkin, Shiwei Zheng, Kai Yan, Shengbao Suo, and Ruben Dries. Guo-Cheng Yuan often publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Genome Biology, Nature Communications, Nature, and Nature Genetics.

In terms of publication volume, they have contributed significantly to bioRxiv with 19 publications and Genome Biology with 7 publications. Other notable venues include Nature Communications with 5 publications, Nature with 3, and Nature Genetics also with 3.

Best Publications

  • Genome-scale identification of nucleosome positions in S. cerevisiae.

    Guo-Cheng Yuan;Yuen-Jong Liu;Michael F. Dion;Michael D. Slack

  • Mapping the Mouse Cell Atlas by Microwell-Seq

    Xiaoping Han;Renying Wang;Yincong Zhou;Lijiang Fei

  • Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH

    Chee-Huat Linus Eng;Michael Lawson;Qian Zhu;Ruben Dries

  • Lagrangian coherent structures and mixing in two-dimensional turbulence

    G. Haller;G. Yuan

  • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

    Xiaohua Shen;Yingchun Liu;Yu Jung Hsu;Yuko Fujiwara

  • BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

    Matthew C. Canver;Elenoe C. Smith;Falak Sher;Luca Pinello

  • A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

    Deng Pan;Aya Kobayashi;Aya Kobayashi;Peng Jiang;Lucas Ferrari de Andrade

  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

    Semir Beyaz;Semir Beyaz;Miyeko D. Mana;Jatin Roper;Jatin Roper;Dmitriy Kedrin;Dmitriy Kedrin

  • An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

    Daniel E. Bauer;Sophia C. Kamran;Sophia C. Kamran;Samuel Lessard;Jian Xu;Jian Xu

  • Giotto: a toolbox for integrative analysis and visualization of spatial expression data

    Ruben Dries;Ruben Dries;Qian Zhu;Rui Dong;Chee-Huat Linus Eng

  • CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

    Edmond Chipumuro;Eugenio Marco;Camilla L. Christensen;Nicholas Kwiatkowski

  • MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

    Zhen Shao;Zhen Shao;Yijing Zhang;Guo-Cheng Yuan;Stuart H Orkin;Stuart H Orkin;Stuart H Orkin

  • LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

    Gengze Wu;Jin Cai;Yu Han;Jinghai Chen

  • Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

    Xiaohua Shen;Woojin Kim;Yuko Fujiwara;Matthew D. Simon

  • Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.

    Lucas Ferrari de Andrade;Rong En Tay;Deng Pan;Adrienne M. Luoma

  • Analyzing CRISPR genome-editing experiments with CRISPResso

    Pinello L;Canver Mc;Hoban;Orkin Sh

  • Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

    Nan Liu;Victoria V. Hargreaves;Qian Zhu;Jesse V. Kurland

  • The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

    Michael P. Snyder;Shin Lin

  • CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

    Edmond Chipumuro;Eugenio Marco;Camilla L. Christensen;Tinghu Zhang

  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

    Assieh Saadatpour;Sue-Jean Hong;Luca Pinello;Yarden Katz

Frequent Co-Authors

Stuart H. Orkin
Stuart H. Orkin Harvard University
Daniel E. Bauer
Daniel E. Bauer Harvard University
Yuko Fujiwara
Yuko Fujiwara Harvard University
John Quackenbush
John Quackenbush Harvard University
William T. Pu
William T. Pu Boston Children's Hospital
Martin J. Hessner
Martin J. Hessner Medical College of Wisconsin
Kai W. Wucherpfennig
Kai W. Wucherpfennig Harvard University
Nathanael S. Gray
Nathanael S. Gray Stanford University
Tinghu Zhang
Tinghu Zhang Stanford University

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