World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
18853
World Ranking
14776
National Ranking
6179

Overview

Tinghu Zhang is affiliated with Stanford University in the United States and has an extensive body of research primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine.

The scientist's work covers multiple subfields, including Molecular Biology, Oncology, Cell Biology, Organic Chemistry, and Hematology. Their research interests are reflected in their main topics of study, which highlight Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Peptidase Inhibition and Analysis, Cancer-related Molecular Pathways, Click Chemistry and Applications, Hippo pathway signaling and YAP/TAZ, as well as Multiple Myeloma Research and Treatments.

Frequent publication venues for Tinghu Zhang include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cell chemical biology
  • European Journal of Medicinal Chemistry

Notable recent publications include:

  • "Partitioning of cancer therapeutics in nuclear condensates" (2020, Science)
  • "Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway" (2020, Cancer Cell)
  • "A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging" (2020, Cell)
  • "Light-induced control of protein destruction by opto-PROTAC" (2020, Science Advances)
  • "Rewiring cancer drivers to activate apoptosis" (2023, Nature)

Tinghu Zhang has collaborated frequently with several researchers, including:

  • Nathanael S. Gray (66 publications)
  • Jianwei Che (25 publications)
  • Eric S. Fischer (19 publications)
  • Jie Jiang (18 publications)
  • Scott B. Ficarro (17 publications)

Best Publications

  • Systematic identification of genomic markers of drug sensitivity in cancer cells

    Mathew J. Garnett;Elena J. Edelman;Sonja J. Heidorn;Christopher Greenman;Christopher Greenman

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

    Nicholas Kwiatkowski;Tinghu Zhang;Peter B. Rahl;Brian J Abraham

  • Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

    Qingsong Liu;Yogesh Sabnis;Yogesh Sabnis;Zheng Zhao;Tinghu Zhang

  • CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

    Edmond Chipumuro;Eugenio Marco;Camilla L. Christensen;Nicholas Kwiatkowski

  • Plasticity in binding confers selectivity in ligand-induced protein degradation.

    Radosław P. Nowak;Stephen L. DeAngelo;Dennis Buckley;Zhixiang He

  • Partitioning of Cancer Therapeutics in Nuclear Condensates

    Isaac A. Klein;Isaac A. Klein;Ann Boija;Lena K. Afeyan;Susana Wilson Hawken

  • Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

    Calla M Olson;Baishan Jiang;Michael A Erb;Yanke Liang

  • Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

    Camilla L. Christensen;Nicholas Kwiatkowski;Brian J. Abraham;Julian Carretero

  • CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

    Yubao Wang;Tinghu Zhang;Nicholas Kwiatkowski;Brian J. Abraham

  • Discovery of Potent and Selective Covalent Inhibitors of JNK

    Tinghu Zhang;Francisco Inesta-Vaquera;Mario Niepel;Jianming Zhang

  • Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.

    Kari J. Kurppa;Yao Liu;Ciric To;Tinghu Zhang

  • Correction: Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

    Florencia Cayrol;Pannee Praditsuktavorn;Tharu M. Fernando;Nicholas Kwiatkowski

  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

    Tinghu Zhang;Nicholas Kwiatkowski;Nicholas Kwiatkowski;Calla M Olson;Sarah E Dixon-Clarke

  • A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

    Haopeng Xiao;Mark P. Jedrychowski;Devin K. Schweppe;Edward L. Huttlin

  • YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

    Giorgio Giorgio G Galli;Giorgio Giorgio G Galli;Matteo Carrara;Wei-Chien Yuan;Wei-Chien Yuan;Christian Valdes-Quezada

  • Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

    Rinath Jeselsohn;Rinath Jeselsohn;Johann S. Bergholz;Matthew Pun;MacIntosh Cornwell

  • Light-induced control of protein destruction by opto-PROTAC.

    Jing Liu;He Chen;Leina Ma;Zhixiang He

  • Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

    M Catarina Silva;Fleur M Ferguson;Quan Cai;Katherine A Donovan

  • CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

    Edmond Chipumuro;Eugenio Marco;Camilla L. Christensen;Tinghu Zhang

Frequent Co-Authors

Nathanael S. Gray
Nathanael S. Gray Stanford University
Jarrod A. Marto
Jarrod A. Marto Harvard University
Scott B. Ficarro
Scott B. Ficarro Harvard University
James E. Bradner
James E. Bradner Amgen (United States)
Kwok-Kin Wong
Kwok-Kin Wong New York University
Matthias Geyer
Matthias Geyer University of Bonn
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University

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