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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
51394
World Ranking
1959
National Ranking
39

Medicine

D-Index
92
Citations
50986
World Ranking
11080
National Ranking
437

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Lodewyk F. A. Wessels is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research spans extensively across the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Wessels has concentrated on subfields including Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Immunology.

The scientist's work frequently addresses several main topics, including Cancer Immunotherapy and Biomarkers, Cancer Genomics and Diagnostics, Bladder and Urothelial Cancer Treatments, Epigenetics and DNA Methylation, Breast Cancer Treatment Studies, Prostate Cancer Treatment and Research, and Computational Drug Discovery Methods.

Wessels has contributed to numerous publications, some of which have notable impact and visibility. Recent papers include:

  • Effective drug combinations in breast, colon and pancreatic cancer cells (2022, Nature)
  • Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial (2020, Nature Medicine)
  • Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer (2024, New England Journal of Medicine)
  • γδ T cells are effectors of immunotherapy in cancers with HLA class I defects (2023, Nature)
  • The Cancer SENESCopedia: A delineation of cancer cell senescence (2021, Cell Reports)

The scientist has frequently published in a range of venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Clinical Cancer Research
  • Nature
  • Nature Medicine

Wessels has collaborated regularly with several researchers in their field. Notable frequent coauthors include:

  • Jos Jonkers
  • Esther H. Lips
  • Jelle Wesseling
  • Daniël J. Vis
  • Annegien Broeks

Overall, the research profile of Lodewyk F. A. Wessels encompasses a broad interdisciplinary engagement with molecular biology and oncology, focusing on molecular mechanisms and therapeutic interventions in cancer. Their contributions reflect involvement in both experimental and clinical cancer research aiming at improving treatment strategies and understanding of cancer biology.

Best Publications

  • The consensus molecular subtypes of colorectal cancer

    Justin Guinney;Rodrigo Dienstmann;Rodrigo Dienstmann;Xingwu Wang;Xingwu Wang;Aurélien De Reyniès

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

    Andrew V. Biankin;Andrew V. Biankin;Andrew V. Biankin;Nicola Waddell;Karin S. Kassahn;Marie Claude Gingras

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

    Lars Guelen;Ludo Pagie;Emilie Brasset;Wouter Meuleman;Wouter Meuleman

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • Concordance among Gene-Expression–Based Predictors for Breast Cancer

    Cheng Fan;Daniel S Oh;Lodewyk Wessels;Britta Weigelt

  • A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

    Norman Sachs;Joep de Ligt;Oded Kopper;Ewa Gogola

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

    Daan Peric-Hupkes;Wouter Meuleman;Wouter Meuleman;Ludo Pagie;Sophia W.M. Bruggeman

  • Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

    Chong Sun;Liqin Wang;Sidong Huang;Guus J. J. E. Heynen

  • Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial.

    Leonie Voorwerk;Maarten Slagter;Hugo M. Horlings;Karolina Sikorska

  • Refinement of breast cancer classification by molecular characterization of histological special types.

    B Weigelt;H M Horlings;B Kreike;M M Hayes

  • Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

    Riccardo Mezzadra;Chong Sun;Lucas T. Jae;Raquel Gomez-Eerland

  • Converting a breast cancer microarray signature into a high-throughput diagnostic test.

    Annuska M. Glas;Arno Floore;Leonie Jmj M. J. Delahaye;Anke T. Witteveen

  • Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

    Salo N. Ooft;Fleur Weeber;Krijn K. Dijkstra;Chelsea M. McLean

  • Gene expression profiles of primary breast tumors maintained in distant metastases.

    Britta Weigelt;Annuska M. Glas;Lodewyk F. A. Wessels;Anke T. Witteveen

  • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas.

    Paul Roepman;Lodewyk F A Wessels;Lodewyk F A Wessels;Nienke Kettelarij;Patrick Kemmeren

  • MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling.

    Sidong Huang;Michael Hölzel;Theo Knijnenburg;Andreas Schlicker

  • Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

    Xiaoling Liu;Henne Holstege;Hanneke van der Gulden;Marcelle Treur-Mulder

Frequent Co-Authors

Marcel J. T. Reinders
Marcel J. T. Reinders Delft University of Technology
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Jos Jonkers
Jos Jonkers Antoni van Leeuwenhoek Hospital
David J. Adams
David J. Adams Wellcome Sanger Institute
Jelle Wesseling
Jelle Wesseling Leiden University Medical Center
Laura J. van't Veer
Laura J. van't Veer University of California, San Francisco
Mathew J. Garnett
Mathew J. Garnett Wellcome Sanger Institute
Roderick L. Beijersbergen
Roderick L. Beijersbergen Antoni van Leeuwenhoek Hospital
Ultan McDermott
Ultan McDermott AstraZeneca (United Kingdom)
Maarten van Lohuizen
Maarten van Lohuizen Antoni van Leeuwenhoek Hospital

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