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Roderick L. Beijersbergen

Roderick L. Beijersbergen

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
28986
World Ranking
11664
National Ranking
301

Overview

Roderick L. Beijersbergen is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. Within these domains, their work is concentrated in Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cancer Research, and Immunology.

The scientist's main research topics include CRISPR and Genetic Engineering, DNA Repair Mechanisms, Genomics and Chromatin Dynamics, PARP inhibition in cancer therapy, Cancer-related Molecular Pathways, RNA Research and Splicing, and Ubiquitin and proteasome pathways.

They have contributed to a series of publications in notable venues. Frequent places of publication include bioRxiv (Cold Spring Harbor Laboratory), SSRN Electronic Journal, Nature Communications, Nucleic Acids Research, and Molecular Cell.

Some of their recent papers are:

  • EGFR activation limits the response of liver cancer to lenvatinib, 2021, Nature
  • Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance, 2021, Molecular Cell
  • The Cancer SENESCopedia: A delineation of cancer cell senescence, 2021, Cell Reports
  • A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer, 2020, eLife
  • Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps, 2021, Molecular Cell

Roderick L. Beijersbergen has collaborated frequently with several researchers, including Cor Lieftink, Ben Morris, René Bernards, Liqin Wang, and Wilbert Zwart.

Best Publications

  • Creation of human tumour cells with defined genetic elements

    William C. Hahn;William C. Hahn;Christopher M. Counter;Ante S. Lundberg;Ante S. Lundberg;Roderick L. Beijersbergen

  • hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

    Matthew Meyerson;Christopher M Counter;Elinor Ng Eaton;Leif W Ellisen

  • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

    Anirudh Prahallad;Chong Sun;Sidong Huang;Federica Di Nicolantonio

  • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

    Katrien Berns;Hugo M. Horlings;Bryan T. Hennessy;Mandy Madiredjo

  • A large-scale RNAi screen in human cells identifies new components of the p53 pathway

    Katrien Berns;E. Marielle Hijmans;Jasper Mullenders;Thijn R. Brummelkamp

  • Inhibition of telomerase limits the growth of human cancer cells

    William C. Hahn;Sheila A. Stewart;Mary W. Brooks;Shoshana G. York

  • Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

    Chong Sun;Liqin Wang;Sidong Huang;Guus J. J. E. Heynen

  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

    Christopher M. Counter;William C. Hahn;Wenyi Wei;Stephanie Dickinson Caddle

  • Statistical methods for analysis of high-throughput RNA interference screens

    Amanda Birmingham;Laura M Selfors;Thorsten Forster;David Wrobel

  • Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

    Tobias Otto;Sebastian Horn;Markus Brockmann;Ursula Eilers

  • Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235

    Pieter J.A. Eichhorn;Magüi Gili;Maurizio Scaltriti;Violeta Serra

  • The ubiquitin-specific protease USP28 is required for MYC stability

    Nikita Popov;Michael Wanzel;Mandy Madiredjo;Dong Zhang

  • MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling.

    Sidong Huang;Michael Hölzel;Theo Knijnenburg;Andreas Schlicker

  • E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

    R.L. Beijersbergen;R.M. Kerkhoven;L. Zhu;L. Carlée

  • CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

    Bastiaan Evers;Katarzyna Jastrzebski;Jeroen P M Heijmans;Wipawadee Grernrum

  • Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

    Coenraad Kuijl;Nigel D. L. Savage;Marije Marsman;Adriaan W. Tuin

  • Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

    R.L. Beijersbergen;L. Carlée;R.M. Kerkhoven;R.A. Bernards

  • E2F-5, a new E2F family member that interacts with p130 in vivo.

    E.M. Hijmans;P.M. Voorhoeve;R.L. Beijersbergen;L.J. van 't Veer

  • Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3

    Chong Sun;Sebastijan Hobor;Andrea Bertotti;Davide Zecchin

  • A Genetic Screen Identifies PITX1 as a Suppressor of RAS Activity and Tumorigenicity

    Ingrid G.M. Kolfschoten;Bart van Leeuwen;Katrien Berns;Jasper Mullenders

Frequent Co-Authors

René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Lodewyk F. A. Wessels
Lodewyk F. A. Wessels Antoni van Leeuwenhoek Hospital
Hubert E. Blum
Hubert E. Blum University of Freiburg
Alberto Bardelli
Alberto Bardelli University of Turin
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Theo A. Knijnenburg
Theo A. Knijnenburg Altius Institute for Biomedical Sciences
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Matthew Meyerson
Matthew Meyerson Harvard University
Bas van Steensel
Bas van Steensel Antoni van Leeuwenhoek Hospital

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