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Christopher M. Counter

Christopher M. Counter

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
27015
World Ranking
10518
National Ranking
4564

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Christopher M. Counter is affiliated with Duke University in the United States, focusing on research in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their body of work includes substantial contributions to Molecular Biology, Oncology, Cell Biology, Cancer Research, and Biotechnology.

The scientist's recent publications reflect diverse topics within cancer and molecular biology research. Notable papers include:

  • Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity (2021, Nature Communications)
  • CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment (2021, Cell Reports)
  • Capturing the primordial Kras mutation initiating urethane carcinogenesis (2020, Nature Communications)
  • Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway (2020, Scientific Reports)
  • Signaling levels mold the RAS mutation tropism of urethane (2021, eLife)

Research topics explored by Christopher M. Counter include:

  • RNA and protein synthesis mechanisms
  • Cancer Genomics and Diagnostics
  • Cellular transport and secretion
  • Cancer-related Molecular Pathways
  • Cancer Research and Treatments
  • Protein Kinase Regulation and GTPase Signaling
  • DNA Repair Mechanisms

Frequent co-authors in their research collaborations have been:

  • Seth P. Zimmerman
  • Özgün Erdoğan
  • Corinne M. Linardic
  • Siqi Li
  • Nicole L. Pershing

Publication venues where Christopher M. Counter has frequently contributed include:

  • Cancer Research
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife

The scientist's work spans core areas of cancer research, with particular interest in molecular pathways related to oncogenic mutations such as KRAS, DNA damage response mechanisms, and gene expression regulation through signaling pathways like MAPK.

Christopher M. Counter was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2014, acknowledging their contributions to scientific research.

Best Publications

  • Creation of human tumour cells with defined genetic elements

    William C. Hahn;William C. Hahn;Christopher M. Counter;Ante S. Lundberg;Ante S. Lundberg;Roderick L. Beijersbergen

  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

    C.M. Counter;A.A. Avilion;C.E. LeFeuvre;N.G. Stewart

  • hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

    Matthew Meyerson;Christopher M Counter;Elinor Ng Eaton;Leif W Ellisen

  • Telomerase activity in normal leukocytes and in hematologic malignancies.

    Christopher M. Counter;Jyothi Gupta;Calvin B. Harley;Brian Leber

  • Telomerase activity in human ovarian carcinoma.

    Christopher M. Counter;Hal W. Hirte;Silvia Bacchetti;Calvin B. Harley

  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

    Elizabeth Yeh;Melissa Cunningham;Hugh Arnold;Dawn Chasse

  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

    Christopher M. Counter;William C. Hahn;Wenyi Wei;Stephanie Dickinson Caddle

  • The telomere hypothesis of cellular aging.

    Calvin B. Harley;Homayoun Vaziri;Christopher M. Counter;Richard C. Allsopp

  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

    Christopher M Counter;Matthew Meyerson;Matthew Meyerson;Elinor Ng Eaton;Leif W Ellisen

  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.

    Jennifer A. Kashatus;Aldo Nascimento;Lindsey J. Myers;Annie Sher

  • Distinct requirements for Ras oncogenesis in human versus mouse cells

    Nesrin M. Hamad;Joel H. Elconin;Antoine E. Karnoub;Wenli Bai

  • Telomerase, Cell Immortality, and Cancer

    C. B. Harley;N. W. Kim;K. R. Prowse;S. L. Weinrich

  • Copper is required for oncogenic BRAF signalling and tumorigenesis

    Donita C. Brady;Matthew S. Crowe;Michelle L. Turski;G. Aaron Hobbs

  • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis

    Brooke Ancrile;Kian Huat Lim;Christopher M. Counter

  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes.

    C. M. Counter;F. M. Botelho;Ping Wang;C. B. Harley

  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.

    Songtao Shi;Stan Gronthos;Stan Gronthos;Shaoqiong Chen;Anand Reddi

  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells

    Kian Huat Lim;Antonio T. Baines;James J. Fiordalisi;Michail Shipitsin

  • RALA and RALBP1 regulate mitochondrial fission at mitosis

    David F. Kashatus;Kian Huat Lim;Kian Huat Lim;Donita C. Brady;Donita C. Brady;Nicole L.K. Pershing

  • Tumour maintenance is mediated by eNOS

    Kian Huat Lim;Kian Huat Lim;Brooke B. Ancrile;David F. Kashatus;Christopher M. Counter

  • Abstract IA09: Copper is required for oncogenic BRAF signaling and tumorigenesis

    Donita Brady;Matt Crowe;Michelle Turski;Aaron Hobbs

Frequent Co-Authors

Lawrence B. Schook
Lawrence B. Schook University of Illinois at Urbana-Champaign
Calvin B. Harley
Calvin B. Harley Geron (United States)
Silvia Bacchetti
Silvia Bacchetti McMaster University
Matthew Meyerson
Matthew Meyerson Harvard University
Dennis J. Thiele
Dennis J. Thiele Sisu Pharma
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Sharon L. Campbell
Sharon L. Campbell University of North Carolina at Chapel Hill
Xiao-Fan Wang
Xiao-Fan Wang Duke University

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