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Molecular Biology

D-Index
69
Citations
23087
World Ranking
1452
National Ranking
24

Research.com Recognitions

  • 2020 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Joachim Lingner is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research primarily focuses on molecular biology aspects related to telomeres, DNA repair mechanisms, and aging. Their work encompasses various fields including biochemistry, genetics, molecular biology, and medicine, with subfields covering molecular biology, physiology, biophysics, aging, and biomedical engineering.

Their main research topics include:

  • Telomeres, Telomerase, and Senescence
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Advanced biosensing and bioanalysis techniques
  • Genetics, Aging, and Longevity in Model Organisms
  • RNA regulation and disease
  • Mitochondrial Function and Pathology

Joachim Lingner has published extensively, with notable recent papers including:

  • "RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops," 2020, Nature
  • "The makings of TERRA R-loops at chromosome ends," 2021, Cell Cycle
  • "Human shelterin protein POT 1 prevents severe telomere instability induced by homology-directed DNA repair," 2020, The EMBO Journal
  • "The human telomeric proteome during telomere replication," 2021, Nucleic Acids Research
  • "PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage," 2020, Cell Reports

Their frequent co-authors include Rita Valador Fernandes, Galina Glousker, Marianna Feretzaki, T. Lunardi, and Eftychia Kyriacou.

The main venues where Joachim Lingner's work has been published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Nucleic Acids Research
  • Nature
  • Cell Cycle

Joachim Lingner has received recognition from scientific societies, including being named a Member of Academia Europaea in 2020 and holding membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Telomerase catalytic subunit homologs from fission yeast and human

    Toru M. Nakamura;Gregg B. Morin;Gregg B. Morin;Karen B. Chapman;Karen B. Chapman;Scott L. Weinrich;Scott L. Weinrich

  • Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

    Joachim Lingner;Timothy R. Hughes;Andrej Shevchenko;Matthias Mann

  • Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.

    Claus M. Azzalin;Patrick Reichenbach;Lela Khoriauli;Elena Giulotto

  • Direct activation of TERT transcription by c-MYC.

    Kou-Juey Wu;Carla Grandori;Mario Amacker;Nathalie Simon-Vermot

  • Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States

    M.Teresa Teixeira;Milica Arneric;Peter Sperisen;Joachim Lingner

  • A highly selective telomerase inhibitor limiting human cancer cell proliferation

    Klaus Damm;Ulrike Hemmann;Pilar Garin‐Chesa;Norbert Hauel

  • Telomerase and DNA end replication: no longer a lagging strand problem?

    Joachim Lingner;Julia Promisel Cooper;Thomas R. Cech

  • The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

    Sophie Redon;Patrick Reichenbach;Joachim Lingner

  • The human CST complex is a terminator of telomerase activity

    Liuh-Yow Chen;Sophie Redon;Joachim Lingner

  • Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.

    Joachim Lingner;Thomas R. Cech

  • Telomere Length Homeostasis

    Nele Hug;Joachim Lingner

  • Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

    Emanuelle Pascolo;Christian Wenz;Joachim Lingner;Norbert Hauel

  • The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

    Brian Luke;Andrea Panza;Sophie Redon;Nahid Iglesias

  • Telomere length homeostasis requires that telomerase levels are limiting.

    Gaël Cristofari;Joachim Lingner;Joachim Lingner

  • Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

    Anne De Cian;Gael Cristofari;Patrick Reichenbach;Elsa De Lemos

  • Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity

    Joachim Lingner;Thomas R. Cech;Timothy R. Hughes;Victoria Lundblad

  • TERRA: telomeric repeat-containing RNA.

    Brian Luke;Joachim Lingner

  • TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.

    Eladio Abreu;Elena Aritonovska;Patrick Reichenbach;Gaël Cristofari

  • Regulation of the human telomerase reverse transcriptase gene

    Anne-Lyse Ducrest;Henrietta Szutorisz;Joachim Lingner;Markus Nabholz

  • Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.

    J Lingner;L L Hendrick;T R Cech

Frequent Co-Authors

Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
Gregg B. Morin
Gregg B. Morin University of British Columbia
Calvin B. Harley
Calvin B. Harley Geron (United States)
Walter Keller
Walter Keller University of Basel
Philipp Bucher
Philipp Bucher École Polytechnique Fédérale de Lausanne
Susan M. Gasser
Susan M. Gasser Friedrich Miescher Institute
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry
G. Paolo Dotto
G. Paolo Dotto Harvard University
Rodney Rothstein
Rodney Rothstein Columbia University
Denis Duboule
Denis Duboule Collège de France

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