World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
18283
World Ranking
7336
National Ranking
3361

Overview

G. Paolo Dotto is affiliated with Harvard University in the United States. Their research focuses primarily on biochemistry, genetics, molecular biology, and medicine. The scientist has an extensive publication record, with 28 works in Biochemistry, Genetics and Molecular Biology, and 16 in Medicine. Subfields of particular interest include molecular biology, oncology, immunology, genetics, and biophysics.

Their investigations cover several key topics in biomedical research related to cancer and immune responses. These topics include:

  • Melanoma and MAPK Pathways
  • Cancer-related gene regulation
  • Cancer-related Molecular Pathways
  • Cancer Cells and Metastasis
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Interferon and immune responses

Frequent publication venues for G. Paolo Dotto are:

  • EMBO Reports
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • The Journal of Experimental Medicine

The following are notable recent research papers authored by Dotto, listed with publication year and venue:

  • "Sphingolipids control dermal fibroblast heterogeneity," 2022, Science
  • "Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis," 2020, The Journal of Experimental Medicine
  • "NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin," 2020, Nature Communications
  • "ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation," 2024, Nature Communications
  • "Androgen receptor is a determinant of melanoma targeted drug resistance," 2023, Nature Communications

Frequent co-authors collaborating with G. Paolo Dotto include:

  • Luigi Mazzeo
  • Soumitra Ghosh
  • Paola Ostano
  • Min Ma
  • Anastasia Samarkina

Best Publications

  • Notch1 functions as a tumor suppressor in mouse skin.

    Michael Nicolas;Anita Wolfer;Kenneth Raj;J Alain Kummer

  • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

    Annapoorni Rangarajan;Annapoorni Rangarajan;Claudio Talora;Ryuhei Okuyama;Michael Nicolas

  • Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis

    Zhao Jun Liu;Takashi Shirakawa;Yan Li;Akinobu Soma

  • p21WAF1/Cip1: more than a break to the cell cycle?

    G.Paolo Dotto

  • Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

    Bach Cuc Nguyen;Karine Lefort;Anna Mandinova;Dario Antonini

  • Control of murine hair follicle regression (catagen) by TGF-β1 in vivo

    Kerstin Foitzik;Kerstin Foitzik;Gerd Lindner;Sven Mueller-Roever;Marcus Maurer

  • Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

    Claudio Talora;Dennis C. Sgroi;Christopher P. Crum;G. Paolo Dotto

  • The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

    C Missero;F Di Cunto;H Kiyokawa;A Koff

  • Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases

    Karine Lefort;Anna Mandinova;Paola Ostano;Vihren Kolev

  • Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.

    Enzo Calautti;Sara Cabodi;Paul L. Stein;Mechthild Hatzfeld

  • Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

    Ferdinando Di Cunto;Gabrielle Topley;Enzo Calautti;Jimmy Hsiao

  • Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

    G. Paolo Dotto;G. Paolo Dotto;Anil K. Rustgi

  • Opposing roles for calcineurin and ATF3 in squamous skin cancer

    Xunwei Wu;Bach-Cuc Nguyen;Piotr Dziunycz;Sungeun Chang;Sungeun Chang

  • Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

    Ferdinando Di Cunto;Sara Imarisio;Emilio Hirsch;Vania Broccoli

  • Specific growth response of ras-transformed embryo fibroblasts to tumour promoters.

    Gian Paolo Dotto;Luis F. Parada;Robert A. Weinberg

  • Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

    Fumiko Itoh;Fumiko Itoh;Susumu Itoh;Susumu Itoh;Marie-José Goumans;Gudrun Valdimarsdottir

  • p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

    Vikram Devgan;Cristina Mammucari;Sarah E. Millar;Cathrin Brisken

  • EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

    Vihren Kolev;Anna Mandinova;Juan Guinea-Viniegra;Bing Hu

  • Impact of normalization on miRNA microarray expression profiling.

    Sylvain Pradervand;Johann Weber;Jérôme Thomas;Manuel Bueno

  • Tyrosine phosphorylation and SRC family kinases control keratinocyte cell-cell adhesion

    Enzo Calautti;Sara Cabodi;Nancy Kedersha;G.Paolo Dotto

Frequent Co-Authors

Reinhard Dummer
Reinhard Dummer University of Zurich
Sam W. Lee
Sam W. Lee Broad Institute
Giovanni Ciriello
Giovanni Ciriello University of Lausanne
Dong-Eun Kim
Dong-Eun Kim Konkuk University
Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Anne J. Ridley
Anne J. Ridley University of Bristol
Thomas Doetschman
Thomas Doetschman University of Arizona
Freddy Radtke
Freddy Radtke École Polytechnique Fédérale de Lausanne
Susumu Itoh
Susumu Itoh Showa Pharmaceutical University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing G. Paolo Dotto

Trending Scientists

Recently Published Articles