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Genetics

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Molecular Biology

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473
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Research.com Recognitions

  • 2007 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Member of the National Academy of Sciences
  • 2000 - Royal Netherlands Academy of Arts and Sciences

Overview

Titia de Lange is affiliated with Rockefeller University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a focus on molecular biology and physiology. Their research prominently addresses topics related to telomeres, telomerase, senescence, DNA repair mechanisms, CRISPR and genetic engineering, chromosomal and genetic variations, genomics and chromatin dynamics, as well as advanced biosensing and bioanalysis techniques.

De Lange's publication record includes numerous papers in prominent scientific journals. Recent notable papers are:

  • Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs (2020, Cell)
  • 53BP1: a DSB escort (2020, Genes & Development)
  • APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis (2020, Nature Genetics)
  • Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication (2021, Genes & Development)
  • ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity (2020, PLoS Biology)

The frequent co-authors collaborating with de Lange include Kaori Takai, Sarah W. Cai, Thomas Walz, Hiroyuki Takai, and Sannie Culbertson. These collaborations have contributed to the body of work across multiple publications.

Preferred venues for publication by this researcher include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • Trends in Biochemical Sciences
  • UNC Libraries
  • Cell

Their work spans several specific subfields within the broader domain of biochemistry and molecular biology, notably molecular biology, physiology, plant science, aging, and cancer research. Research topics explored cover a range of cellular and genetic processes, particularly emphasizing telomere biology and DNA repair pathways.

Recognition for contributions to science includes election as a Fellow of the American Academy of Arts and Sciences in 2007, membership in the National Academy of Sciences since 2006, and affiliation with the Royal Netherlands Academy of Arts and Sciences since 2000.

Best Publications

  • Shelterin: the protein complex that shapes and safeguards human telomeres

    Titia de Lange

  • Mammalian Telomeres End in a Large Duplex Loop

    Jack D Griffith;Laurey Comeau;Soraya Rosenfield;Rachel M Stansel

  • TRF2 Protects Human Telomeres from End-to-End Fusions

    Bas van Steensel;Agata Smogorzewska;Titia de Lange

  • How Shelterin Protects Mammalian Telomeres

    Wilhelm Palm;Titia de Lange

  • DNA Damage Foci at Dysfunctional Telomeres

    Hiroyuki Takai;Agata Smogorzewska;Titia de Lange

  • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

    Jan Karlseder;Dominique Broccoli;Yumin Dai;Stephen Hardy

  • Protection of mammalian telomeres

    Titia de Lange

  • Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres

    Susan Smith;Izabela Giriat;Anja Schmitt;Titia de Lange

  • Structure and variability of human chromosome ends.

    T de Lange;L Shiue;R M Myers;D R Cox

  • Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

    Agnel Sfeir;Settapong T. Kosiyatrakul;Dirk Hockemeyer;Sheila L. MacRae

  • How Telomeres Solve the End-Protection Problem

    Titia de Lange

  • Control of human telomere length by TRF1 and TRF2.

    Agata Smogorzewska;Bas van Steensel;Alessandro Bianchi;Stefan Oelmann

  • Regulation of Telomerase by Telomeric Proteins

    Agata Smogorzewska;Titia de Lange

  • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

    Eros Lazzerini Denchi;Titia de Lange

  • Senescence Induced by Altered Telomere State, Not Telomere Loss

    Jan Karlseder;Agata Smogorzewska;Titia de Lange

  • A Human Telomeric Protein

    Laura Chong;Bas van Steensel;Dominique Broccoli;Hediye Erdjument-Bromage

  • POT1 as a terminal transducer of TRF1 telomere length control

    Diego Loayza;Titia de Lange

  • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

    Giulia B. Celli;Titia de Lange

  • Identification of Human Rap1: Implications for Telomere Evolution

    Bibo Li;Stephanie Oestreich;Titia de Lange

  • Shelterin-Mediated Telomere Protection.

    Titia de Lange

Frequent Co-Authors

Dirk Hockemeyer
Dirk Hockemeyer University of California, Berkeley
Susan Smith
Susan Smith New York University
Agata Smogorzewska
Agata Smogorzewska Rockefeller University
Bas van Steensel
Bas van Steensel Antoni van Leeuwenhoek Hospital
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill
Jan Karlseder
Jan Karlseder Salk Institute for Biological Studies
Rameen Beroukhim
Rameen Beroukhim Harvard University
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Marcin Imielinski
Marcin Imielinski Cornell University

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