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Medicine

D-Index
85
Citations
25195
World Ranking
14659
National Ranking
7416

Overview

Sharon A. Savage is affiliated with the National Institutes of Health in the United States. Their research spans across multiple areas within medicine and biochemistry, genetics, and molecular biology, with a significant focus on molecular biology, physiology, genetics, oncology, and cancer research.

Their work often addresses key topics such as telomeres, telomerase, and senescence, cancer-related molecular pathways, cancer genomics and diagnostics, epigenetics and DNA methylation, DNA repair mechanisms, genomics and rare diseases, as well as genomic variations and chromosomal abnormalities.

Sharon A. Savage has published extensively, with some of the recent papers including:

  • Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma (2020, JAMA Oncology)
  • Specifications of the ACMG/AMP variant interpretation guidelines for germline TP53 variants (2020, Human Mutation)
  • The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute (2022, Cell Death and Differentiation)
  • Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries (2022, Nature Genetics)
  • Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set (2021, JAMA Oncology)

The frequent co-authors in their publications include Neelam Giri, Payal P. Khincha, Lisa J. McReynolds, Blanche P. Alter, and Kelvin C. de Andrade.

Sharon A. Savage's research is often published in prominent venues such as Blood, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and Human Mutation.

Best Publications

  • Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program

    Lisa Mirabello;Rebecca J. Troisi;Rebecca J. Troisi;Sharon A. Savage

  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons

    Lisa Mirabello;Rebecca J. Troisi;Rebecca J. Troisi;Sharon A. Savage

  • Detectable clonal mosaicism and its relationship to aging and cancer

    Kevin B. Jacobs;Kevin B. Jacobs;Meredith Yeager;Meredith Yeager;Weiyin Zhou;Weiyin Zhou;Sholom Wacholder

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.

    Maria Teresa Landi;Nilanjan Chatterjee;Kai Yu;Lynn R. Goldin

  • Cancer in dyskeratosis congenita.

    Blanche P. Alter;Neelam Giri;Sharon A. Savage;Philip S. Rosenberg

  • The association of telomere length and cancer: a meta-analysis.

    Ingrid M. Wentzensen;Lisa Mirabello;Ruth M. Pfeiffer;Sharon A. Savage

  • Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

    Christian P. Kratz;Maria Isabel Achatz;Laurence Brugieres;Thierry Frebourg

  • Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li‐Fraumeni syndrome cohort

    Phuong L. Mai;Ana F. Best;June A. Peters;Rosamma M. DeCastro

  • TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

    Sharon A. Savage;Neelam Giri;Gabriela M. Baerlocher;Nick Orr

  • Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy.

    D. Matthew Gianferante;Lisa Mirabello;Sharon A. Savage

  • Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita.

    Blanche P. Alter;Gabriela M. Baerlocher;Sharon A. Savage;Stephen J. Chanock

  • Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.

    Jianxin Shi;Xiaohong R. Yang;Bari Ballew;Melissa Rotunno

  • Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study.

    Blanche P. Alter;Neelam Giri;Sharon A. Savage;June A. Peters

  • Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up.

    Blanche P Alter;Neelam Giri;Sharon A Savage;Philip S Rosenberg

  • Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

    Franklin Zhong;Sharon A. Savage;Marina Shkreli;Neelam Giri

  • Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

    Sharon A. Savage;Lisa Mirabello

  • Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

    Luis F. Z. Batista;Matthew F. Pech;Franklin L. Zhong;Ha Nam Nguyen

  • The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer.

    Lisa Mirabello;Wen Yi Huang;Jason Y.Y. Wong;Nilanjan Chatterjee

  • Detectable clonal mosaicism and its relationship to aging and cancer

    Kevin B. Jacobs;Meredith Yeager;Weiyin Zhou;Sholom Wacholder

Frequent Co-Authors

Blanche P. Alter
Blanche P. Alter National Institutes of Health
Lisa Mirabello
Lisa Mirabello National Institutes of Health
Stephen J. Chanock
Stephen J. Chanock National Institutes of Health
Meredith Yeager
Meredith Yeager Hood College
Stephanie J. Lee
Stephanie J. Lee Fred Hutchinson Cancer Research Center
Margaret A. Tucker
Margaret A. Tucker National Institutes of Health
Immaculata De Vivo
Immaculata De Vivo Harvard University
Neal D. Freedman
Neal D. Freedman National Institutes of Health
Robert N. Hoover
Robert N. Hoover National Institutes of Health
Zhaoming Wang
Zhaoming Wang St. Jude Children's Research Hospital

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