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Biology and Biochemistry

D-Index
46
Citations
14949
World Ranking
18828
National Ranking
7691

Overview

Jan Karlseder is affiliated with the Salk Institute for Biological Studies in the United States. Their research primarily focuses on topics related to telomeres, telomerase, and senescence. Karlseder's work spans several interconnected fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a particular emphasis on physiology, molecular biology, aging, immunology, and surgery.

The scientist has contributed to understanding DNA repair mechanisms, genetics, aging, and longevity in model organisms, as well as advancing molecular biology techniques and applications. Additional interests include single-cell and spatial transcriptomics and tissue engineering and regenerative medicine, with some work exploring circadian rhythm and melatonin.

Frequent collaborators in Karlseder's research have been Joe Nassour, Candy Haggblom, T. Schmidt, Carly Tyer, and Preeyesh Rughani. Through these collaborations, the scientist has published in a range of venues notably:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature

Among their recent published papers are:

  • "Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis" (2023, Nature)
  • "Telomeres and Cancer: Resolving the Paradox" (2021, Annual Review of Cancer Biology)
  • "High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer" (2024, Nature Communications)
  • "Telomeres as hotspots for innate immunity and inflammation" (2023, DNA Repair)
  • "Telomere function and regulation from mouse models to human ageing and disease" (2024, Nature Reviews Molecular Cell Biology)

Best Publications

  • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

    Jan Karlseder;Dominique Broccoli;Yumin Dai;Stephen Hardy

  • Telomeres: protecting chromosomes against genome instability

    Roderick J. O'Sullivan;Jan Karlseder

  • Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

    Agnel Sfeir;Settapong T. Kosiyatrakul;Dirk Hockemeyer;Sheila L. MacRae

  • Senescence Induced by Altered Telomere State, Not Telomere Loss

    Jan Karlseder;Agata Smogorzewska;Titia de Lange

  • Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

    Laure Crabbe;Ramiro E. Verdun;Candy I. Haggblom;Jan Karlseder

  • Replication and protection of telomeres.

    Ramiro E. Verdun;Jan Karlseder

  • Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.

    J Karlseder;H Rotheneder;E Wintersberger

  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.

    Jan Karlseder;Kristina Hoke;Olga K Mirzoeva;Christopher Bakkenist

  • DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.

    Agata Smogorzewska;Jan Karlseder;Heidi Holtgreve-Grez;Anna Jauch

  • Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

    Roderick J O'Sullivan;Stefan Kubicek;Stuart L Schreiber;Stuart L Schreiber;Stuart L Schreiber;Jan Karlseder

  • TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

    Rachel Litman Flynn;Richard C. Centore;Roderick J. O’Sullivan;Rekha Rai

  • The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres

    Ramiro E. Verdun;Jan Karlseder

  • Autophagic cell death restricts chromosomal instability during replicative crisis.

    Joe Nassour;Robert Radford;Adriana Correia;Javier Miralles Fusté

  • Functional human telomeres are recognized as DNA damage in G2 of the cell cycle.

    Ramiro E. Verdun;Laure Crabbe;Candy Haggblom;Jan Karlseder

  • Telomere dysfunction as a cause of genomic instability in Werner syndrome

    Laure Crabbe;Anna Jauch;Colleen M. Naeger;Heidi Holtgreve-Grez

  • Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

    Roderick J O'Sullivan;Nausica Arnoult;Daniel H Lackner;Liana Oganesian

  • Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

    Nausica Arnoult;Adriana Correia;Jiao Ma;Anna Merlo

  • Targeted deletion reveals an essential function for the telomere length regulator Trf1.

    Jan Karlseder;Leili Kachatrian;Hiroyuki Takai;Kim Mercer

  • Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer

    Armelle Corpet;Armelle Corpet;Leanne De Koning;Leanne De Koning;Joern Toedling;Alexia Savignoni;Alexia Savignoni

  • Complex interactions between the DNA-damage response and mammalian telomeres

    Nausica Arnoult;Jan Karlseder

Frequent Co-Authors

Titia de Lange
Titia de Lange Rockefeller University
Andrew Dillin
Andrew Dillin University of California, Berkeley
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Anna Jauch
Anna Jauch Heidelberg University
Geneviève Almouzni
Geneviève Almouzni Institute Curie
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Emmanuel Barillot
Emmanuel Barillot Institute Curie
Agata Smogorzewska
Agata Smogorzewska Rockefeller University
Pyong Woo Park
Pyong Woo Park Boston Children's Hospital
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego

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