World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
12310
World Ranking
18840
National Ranking
7698

Overview

Pyong Woo Park is affiliated with Boston Children's Hospital in the United States. The scientific work centers on several intersecting fields, including biochemistry, genetics, molecular biology, medicine, and immunology and microbiology. Subfields prominently involved in this research include immunology, cell biology, molecular biology, oncology, and ophthalmology.

The main topics covered in Pyong Woo Park's research encompass proteoglycans and glycosaminoglycans, glycosylation and glycoproteins, immune response and inflammation, neutrophil and oxidative mechanisms, ocular infections and treatments, advanced glycation end products, and drug-induced hepatotoxicity and protection.

Frequent publication venues for Park's work include Proteoglycan Research, Science Translational Medicine, American Journal of Physiology-Cell Physiology, mBio, and Nature Communications.

Notable recent papers authored or co-authored by Park are:

  • Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure, 2020, Science Translational Medicine
  • Coreceptor functions of cell surface heparan sulfate proteoglycans, 2022, American Journal of Physiology-Cell Physiology
  • Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils, 2020, mBio
  • A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia, 2020, Nature Communications
  • Role of HSPGs in Systemic Bacterial Infections, 2021, Methods in molecular biology

Park collaborates frequently with a number of researchers, including Atsuko Hayashida, Jian Liu, Kazutaka Hayashida, Rafael Santos de Aquino, and Fuming Zhang.

Best Publications

  • Functions of Cell Surface Heparan Sulfate Proteoglycans

    Merton Bernfield;Martin Götte;Pyong Woo Park;Ofer Reizes

  • Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.

    Qinglang Li;Pyong Woo Park;Carole L. Wilson;William C. Parks

  • Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.

    Marilyn L. Fitzgerald;Zihua Wang;Pyong Woo Park;Gillian Murphy

  • Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

    Pyong Woo Park;Ofer Reizes;Merton Bernfield

  • Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.

    Rosemary A. Kozar;Zhanglong Peng;Rongzhen Zhang;John B. Holcomb

  • Molecular functions of syndecan-1 in disease.

    Yvonne Hui-Fang Teng;Rafael S. Aquino;Pyong Woo Park

  • Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence

    Pyong Woo Park;Pyong Woo Park;Gerald B. Pier;Michael T. Hinkes;Merton Bernfield

  • Modulation of Syndecan-1 Shedding after Hemorrhagic Shock and Resuscitation

    Ricky J. Haywood-Watson;John B. Holcomb;Ernest A. Gonzalez;Zhanglong Peng

  • Molecular and Cellular Mechanisms of Ectodomain Shedding

    Kazutaka Hayashida;Allison H. Bartlett;Ye Chen;Pyong Woo Park

  • Syndecan-1 Shedding Is Enhanced by LasA, a Secreted Virulence Factor of Pseudomonas aeruginosa

    Pyong Woo Park;Gerald B. Pier;Michael J. Preston;Olga Goldberger

  • Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1.

    Zhanglong Peng;Shibani Pati;Shibani Pati;Daniel Potter;Ryan Brown

  • Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines.

    Kazutaka Hayashida;William C. Parks;Pyong Woo Park

  • The Elastin-binding Protein of Staphylococcus aureus(EbpS) Is Expressed at the Cell Surface as an Integral Membrane Protein and Not as a Cell Wall-associated Protein

    Robert Downer;Fiona Roche;Pyong Woo Park;Robert P. Mecham

  • The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin

    Fiona M. Roche;Robert Downer;Fiona Keane;Pietro Speziale

  • Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function

    Lars Bode;Camilla Salvestrini;Pyong Woo Park;Jin-Ping Li

  • Glycosaminoglycans and infection

    Rafael S Aquino;Pyong Woo Park

  • Proteoglycans in host-pathogen interactions: molecular mechanisms and therapeutic implications.

    Allison H. Bartlett;Pyong Woo Park

  • Molecular cloning and expression of the gene for elastin-binding protein (ebpS) in Staphylococcus aureus

    Pyong Woo Park;Joel Rosenbloom;William R. Abrams;Joan Rosenbloom

  • Activation of syndecan-1 Ectodomain shedding by staphylococcus aureus α-toxin and β-toxin

    Pyong Woo Park;Timothy J. Foster;Eiichiro Nishi;Sheila J. Duncan

  • Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.

    Atsuko Hayashida;Allison H. Bartlett;Timothy J. Foster;Pyong Woo Park

Frequent Co-Authors

Robert P. Mecham
Robert P. Mecham Washington University in St. Louis
Merton Bernfield
Merton Bernfield Harvard University
William C. Parks
William C. Parks Cedars-Sinai Medical Center
Timothy J. Foster
Timothy J. Foster Campden BRI (United Kingdom)
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Robert J. Linhardt
Robert J. Linhardt Rensselaer Polytechnic Institute
David B. Corry
David B. Corry Baylor College of Medicine
John B. Holcomb
John B. Holcomb University of Alabama at Birmingham
Charles W. Frevert
Charles W. Frevert University of Washington
Hudson H. Freeze
Hudson H. Freeze Discovery Institute

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