World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
26629
World Ranking
3841
National Ranking
1901

Research.com Recognitions

  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1996 - Member of the National Academy of Medicine (NAM)
  • 1972 - Fellow of John Simon Guggenheim Memorial Foundation
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Genetics

Merton Bernfield mainly focuses on Syndecan 1, Cell biology, Proteoglycan, Ectodomain and Biochemistry. His research investigates the link between Syndecan 1 and topics such as Fibroblast growth factor that cross with problems in Heparanase. His research investigates the connection between Cell biology and topics such as Cell that intersect with issues in Mesenchymal stem cell, Extracellular and Mesenchyme.

His Proteoglycan study incorporates themes from Receptor, Transmembrane protein and Signal transduction. He does research in Biochemistry, focusing on Glycosaminoglycan specifically. His work in Glycosaminoglycan tackles topics such as Glycoprotein which are related to areas like Wnt signaling pathway.

His most cited work include:

  • Functions of Cell Surface Heparan Sulfate Proteoglycans (2303 citations)
  • Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans (954 citations)
  • Specificities of heparan sulphate proteoglycans in developmental processes (646 citations)

What are the main themes of his work throughout his whole career to date?

Merton Bernfield spends much of his time researching Syndecan 1, Cell biology, Biochemistry, Proteoglycan and Heparan sulfate. His work carried out in the field of Syndecan 1 brings together such families of science as Cell growth, Transgene, Ectodomain, Transmembrane protein and Molecular biology. His Ectodomain research focuses on Signal transduction and how it connects with Cell surface receptor.

While the research belongs to areas of Cell biology, Merton Bernfield spends his time largely on the problem of Cell, intersecting his research to questions surrounding Effector. His work deals with themes such as Proteases, Chondroitin sulfate, Endothelium and Immunology, which intersect with Heparan sulfate. His Perlecan study deals with Fibroblast growth factor intersecting with Heparanase.

He most often published in these fields:

  • Syndecan 1 (45.16%)
  • Cell biology (45.16%)
  • Biochemistry (38.71%)

What were the highlights of his more recent work (between 1999-2016)?

  • Syndecan 1 (45.16%)
  • Cell biology (45.16%)
  • Heparan sulfate (20.43%)

In recent papers he was focusing on the following fields of study:

Merton Bernfield mostly deals with Syndecan 1, Cell biology, Heparan sulfate, Biochemistry and Receptor. His Syndecan 1 study combines topics from a wide range of disciplines, such as Transgene, Extracellular, Proteoglycan, Ectodomain and Chemokine. His Cell biology research incorporates elements of Cell, Cell growth and Molecular biology.

Merton Bernfield has included themes like Immunology, Chondroitin sulfate, Angiogenesis and Endothelium in his Heparan sulfate study. Merton Bernfield studied Endothelium and Fibroblast growth factor that intersect with Perlecan. His Receptor study integrates concerns from other disciplines, such as Signal transduction and Lipoprotein lipase.

Between 1999 and 2016, his most popular works were:

  • Specificities of heparan sulphate proteoglycans in developmental processes (646 citations)
  • Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase. (360 citations)
  • Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice (325 citations)

Best Publications

  • Functions of Cell Surface Heparan Sulfate Proteoglycans

    Merton Bernfield;Martin Götte;Pyong Woo Park;Ofer Reizes

  • Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

    Merton Bernfield;Robert Kokenyesi;Masato Kato;Michael T. Hinkes

  • Specificities of heparan sulphate proteoglycans in developmental processes

    Norbert Perrimon;Merton Bernfield

  • Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.

    Marilyn L. Fitzgerald;Zihua Wang;Pyong Woo Park;Gillian Murphy

  • Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns.

    C W Kim;O A Goldberger;R L Gallo;M Bernfield

  • Regulated Shedding of Syndecan-1 and -4 Ectodomains by Thrombin and Growth Factor Receptor Activation

    Sukanya V. Subramanian;Marilyn L. Fitzgerald;Merton Bernfield

  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds

    Richard L. Gallo;Minoru Ono;Thomas Povsic;Curtis Page

  • Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

    Pyong Woo Park;Ofer Reizes;Merton Bernfield

  • Identification of CRAMP, a Cathelin-related Antimicrobial Peptide Expressed in the Embryonic and Adult Mouse

    Richard L. Gallo;Katherine J. Kim;Merton Bernfield;Christine A. Kozak

  • Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2

    Masato Kato;Huiming Wang;Varpu Kainulainen;Marilyn L. Fitzgerald

  • B lymphocytes express and lose syndecan at specific stages of differentiation.

    R D Sanderson;P Lalor;M Bernfield

  • Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

    Caroline M. Alexander;Frieda Reichsman;Michael T. Hinkes;John Lincecum

  • Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells.

    A Rapraeger;M Jalkanen;M Bernfield

  • The cell surface proteoglycan from mouse mammary epithelial cells bears chondroitin sulfate and heparan sulfate glycosaminoglycans.

    A Rapraeger;M Jalkanen;E Endo;J Koda

  • Dependence of salivary epithelial morphology and branching morphogenesis upon acid mucopolysaccharide-protein (proteoglycan) at the epithelial surface.

    Merton R. Bernfield;Shib D. Banerjee;Ronald H. Cohn

  • RNA codewords and protein synthesis, VII. On the general nature of the RNA code.

    Marshall W. Nirenberg;Philip Leder;Merton Bernfield;R. Brimacombe

  • Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens.

    J E Koda;A Rapraeger;M Bernfield

  • Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence

    Pyong Woo Park;Pyong Woo Park;Gerald B. Pier;Michael T. Hinkes;Merton Bernfield

  • Hereditary macrothrombocytopathia, nephritis and deafness

    Charles J. Epstein;Mervyn A. Sahud;Carolyn F. Piel;Joseph R. Goodman

  • Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.

    M. Kato;S. Saunders;Hung Nguyen;M. Bernfield

Frequent Co-Authors

Richard L. Gallo
Richard L. Gallo University of California, San Diego
Pyong Woo Park
Pyong Woo Park Boston Children's Hospital
Martin Götte
Martin Götte University of Münster
Markku Jalkanen
Markku Jalkanen Faron Pharmaceuticals
Andrew J. Copp
Andrew J. Copp University College London
Marshall W. Nirenberg
Marshall W. Nirenberg National Institutes of Health
Richard Brimacombe
Richard Brimacombe Max Planck Society
Seppo Vainio
Seppo Vainio University of Oulu
David Warburton
David Warburton University of Southern California
Guido David
Guido David KU Leuven

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