His main research concerns Ribosome, Transfer RNA, Ribosomal protein, Biochemistry and 30S. In general Ribosome, his work in Eukaryotic Ribosome is often linked to Crystallography, Biophysics, Protein subunit and Molecular biology linking many areas of study. His work on P-site as part of general Transfer RNA research is frequently linked to A-site and Stereochemistry, bridging the gap between disciplines.
His biological study spans a wide range of topics, including Eukaryotic Large Ribosomal Subunit and 23S ribosomal RNA. His Oligonucleotide and Diazirine study, which is part of a larger body of work in Biochemistry, is frequently linked to TRNA binding, bridging the gap between disciplines. 30S is often connected to 50S in his work.
His primary scientific interests are in Ribosome, Biochemistry, Molecular biology, 50S and Transfer RNA. His study in the field of Ribosomal protein, 30S, 5S ribosomal RNA and Eukaryotic Ribosome also crosses realms of Protein subunit. His studies deal with areas such as eIF4A, TRNA binding and Eukaryotic Large Ribosomal Subunit as well as Ribosomal protein.
His research integrates issues of RNA polymerase I, 28S ribosomal RNA and 5.8S ribosomal RNA in his study of 5S ribosomal RNA. His work in the fields of Biochemistry, such as Gel electrophoresis, Oligonucleotide and Protein biosynthesis, overlaps with other areas such as Ribonuclease T1 and Peptidyl transferase. His study in the fields of P-site and E-site under the domain of Transfer RNA overlaps with other disciplines such as Stereochemistry, Crystallography and A-site.
Richard Brimacombe focuses on Ribosome, Biochemistry, Transfer RNA, 50S and Crystallography. His work in the fields of Ribosome, such as 5.8S ribosomal RNA and Elongation factor, intersects with other areas such as Protein structure, Molecular biology and Binding site. A majority of his Biochemistry research is a blend of other scientific areas, such as E-site, Eukaryotic Small Ribosomal Subunit, Eukaryotic Ribosome and Eukaryotic Large Ribosomal Subunit.
His 50S research focuses on subjects like 23S ribosomal RNA, which are linked to Ribosomal protein. His Ribosomal protein study incorporates themes from P-site and Peptidyl transferase. Computational biology and Resolution is closely connected to Cryo-electron microscopy in his research, which is encompassed under the umbrella topic of Crystallography.
Richard Brimacombe spends much of his time researching Ribosome, Transfer RNA, Protein biosynthesis, Elongation factor and Molecular biology. Ribosome is frequently linked to Start codon in his study. His Start codon research is multidisciplinary, incorporating elements of Translational efficiency, Eukaryotic translation and 30S.
His Peptidyl transferase research is multidisciplinary, relying on both P-site, 23S ribosomal RNA and Ribosomal protein. His Eukaryotic Small Ribosomal Subunit study combines topics in areas such as 50S, Translational frameshift, E-site and Eukaryotic Ribosome. His Eukaryotic Ribosome study frequently involves adjacent topics like Eukaryotic Large Ribosomal Subunit.
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Visualization of elongation factor Tu on the Escherichia coli ribosome
H. Stark;M. V. Rodnina;J. Rinke-Appel;R. Brimacombe.
RNA codewords and protein synthesis, VII. On the general nature of the RNA code.
Marshall W. Nirenberg;Philip Leder;Merton Bernfield;R. Brimacombe.
Proceedings of the National Academy of Sciences of the United States of America (1965)
A detailed model of the three-dimensional structure of Escherichia coli 16 S ribosomal RNA in situ in the 30 S subunit.
Richard Brimacombe;Johannes Atmadja;Wolfgang Stiege;Dierk Schüler.
Journal of Molecular Biology (1988)
Arrangement of tRNAs in pre- and posttranslocational ribosomes revealed by electron cryomicroscopy.
Holger Stark;Elena V Orlova;Elena V Orlova;Jutta Rinke-Appel;Nicole Jünke.
The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.
Holger Stark;Florian Mueller;Elena V Orlova;Michael Schatz.
The RNA code and protein synthesis.
M Nirenberg;T Caskey;R Marshall;R Brimacombe.
Cold Spring Harbor Symposia on Quantitative Biology (1966)
Secondary structure of the large subunit ribosomal RNA from Escherichia coli, Zea mays chloroplast, and human and mouse mitochondrial ribosomes
Carola Glotz;Christian W Zwieb;Richard Brimacombe;Kaylene Edwards.
Nucleic Acids Research (1981)
Secondary structure comparisons between small subunit ribosomal RNA molecules from six different species
Christian Zwieb;Carola Glotz;Richard Brimacombe.
Nucleic Acids Research (1981)
The Structure of Ribosomal RNA: A Three‐Dimensional Jigsaw Puzzle
FEBS Journal (1995)
A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. I. fitting the RNA to a 3D electron microscopic map at 20 Å
Florian Mueller;Richard Brimacombe.
Journal of Molecular Biology (1997)
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