What is he best known for?
The fields of study he is best known for:
His main research concerns Ribosome, Transfer RNA, Ribosomal protein, Biochemistry and 30S.
In general Ribosome, his work in Eukaryotic Ribosome is often linked to Crystallography, Biophysics, Protein subunit and Molecular biology linking many areas of study.
His work on P-site as part of general Transfer RNA research is frequently linked to A-site and Stereochemistry, bridging the gap between disciplines.
His biological study spans a wide range of topics, including Eukaryotic Large Ribosomal Subunit and 23S ribosomal RNA.
His Oligonucleotide and Diazirine study, which is part of a larger body of work in Biochemistry, is frequently linked to TRNA binding, bridging the gap between disciplines.
30S is often connected to 50S in his work.
His most cited work include:
- Visualization of elongation factor Tu on the Escherichia coli ribosome (322 citations)
- Arrangement of tRNAs in pre- and posttranslocational ribosomes revealed by electron cryomicroscopy. (234 citations)
- RNA codewords and protein synthesis, VII. On the general nature of the RNA code. (221 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Ribosome, Biochemistry, Molecular biology, 50S and Transfer RNA.
His study in the field of Ribosomal protein, 30S, 5S ribosomal RNA and Eukaryotic Ribosome also crosses realms of Protein subunit.
His studies deal with areas such as eIF4A, TRNA binding and Eukaryotic Large Ribosomal Subunit as well as Ribosomal protein.
His research integrates issues of RNA polymerase I, 28S ribosomal RNA and 5.8S ribosomal RNA in his study of 5S ribosomal RNA.
His work in the fields of Biochemistry, such as Gel electrophoresis, Oligonucleotide and Protein biosynthesis, overlaps with other areas such as Ribonuclease T1 and Peptidyl transferase.
His study in the fields of P-site and E-site under the domain of Transfer RNA overlaps with other disciplines such as Stereochemistry, Crystallography and A-site.
He most often published in these fields:
- Ribosome (75.18%)
- Biochemistry (57.66%)
- Molecular biology (35.04%)
What were the highlights of his more recent work (between 1999-2016)?
- Ribosome (75.18%)
- Biochemistry (57.66%)
- Transfer RNA (29.93%)
In recent papers he was focusing on the following fields of study:
Richard Brimacombe focuses on Ribosome, Biochemistry, Transfer RNA, 50S and Crystallography.
His work in the fields of Ribosome, such as 5.8S ribosomal RNA and Elongation factor, intersects with other areas such as Protein structure, Molecular biology and Binding site.
A majority of his Biochemistry research is a blend of other scientific areas, such as E-site, Eukaryotic Small Ribosomal Subunit, Eukaryotic Ribosome and Eukaryotic Large Ribosomal Subunit.
His 50S research focuses on subjects like 23S ribosomal RNA, which are linked to Ribosomal protein.
His Ribosomal protein study incorporates themes from P-site and Peptidyl transferase.
Computational biology and Resolution is closely connected to Cryo-electron microscopy in his research, which is encompassed under the umbrella topic of Crystallography.
Between 1999 and 2016, his most popular works were:
- The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution. (100 citations)
- Evidence against an Interaction between the mRNA Downstream Box and 16S rRNA in Translation Initiation (57 citations)
- Affinity Purification of Ribosomes with a Lethal G2655C Mutation in 23 S rRNA That Affects the Translocation (56 citations)
In his most recent research, the most cited papers focused on:
Richard Brimacombe spends much of his time researching Ribosome, Transfer RNA, Protein biosynthesis, Elongation factor and Molecular biology.
Ribosome is frequently linked to Start codon in his study.
His Start codon research is multidisciplinary, incorporating elements of Translational efficiency, Eukaryotic translation and 30S.
His Peptidyl transferase research is multidisciplinary, relying on both P-site, 23S ribosomal RNA and Ribosomal protein.
His Eukaryotic Small Ribosomal Subunit study combines topics in areas such as 50S, Translational frameshift, E-site and Eukaryotic Ribosome.
His Eukaryotic Ribosome study frequently involves adjacent topics like Eukaryotic Large Ribosomal Subunit.
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