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Robert A. Grassucci

Robert A. Grassucci

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
15111
World Ranking
10157
National Ranking
4441

Research.com Recognitions

  • 2011 - Hildegard H. Crowley Award, Mineralogical Society of America

Overview

Robert A. Grassucci is affiliated with Columbia University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, as well as contributions to Cell Biology, Physiology, Pulmonary and Respiratory Medicine, and Cellular and Molecular Neuroscience.

The scientist's work covers diverse topics including RNA and protein synthesis mechanisms, lipid membrane structure and behavior, protein kinase regulation and GTPase signaling, cellular transport and secretion, RNA modifications and cancer, receptor mechanisms and signaling, and neuropeptides and animal physiology.

Frequent collaborators in Robert A. Grassucci's research include Joachim Frank, Ziao Fu, Oliver B. Clarke, Jinseo Park, and Aurel Frangaj.

Robert A. Grassucci has published in several notable venues, with recurrent contributions to Nature, bioRxiv (Cold Spring Harbor Laboratory), Nature Structural & Molecular Biology, Proceedings of the National Academy of Sciences, and Science Advances.

Recent publications include:

  • Structure of human GABAB receptor in an inactive state, 2020, Nature
  • Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells, 2020, Science Advances
  • Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel, 2020, Nature Structural & Molecular Biology
  • Symmetric activation and modulation of the human calcium-sensing receptor, 2021, Proceedings of the National Academy of Sciences
  • Promiscuous G-protein activation by the calcium-sensing receptor, 2024, Nature

Robert A. Grassucci was awarded the Hildegard H. Crowley Award by the Mineralogical Society of America in 2011.

Best Publications

  • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit.

    Christian M. T. Spahn;Jeffrey S. Kieft;Robert A. Grassucci;Robert A. Grassucci;Pawel A. Penczek

  • A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome

    Joachim Frank;Jun Zhu;Jun Zhu;Pawel A Penczek;Yanhong Li;Yanhong Li

  • Solution Structure of the E. coli 70S Ribosome at 11.5 Å Resolution

    Irene S Gabashvili;Rajendra K Agrawal;Rajendra K Agrawal;Christian M.T Spahn;Christian M.T Spahn;Robert A Grassucci;Robert A Grassucci

  • Structure of the signal recognition particle interacting with the elongation-arrested ribosome

    Mario Halic;Thomas Becker;Martin R. Pool;Christian M. T. Spahn

  • The ribosome at improved resolution: new techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles.

    Pawel A. Penczek;Robert A. Grassucci;Joachim Frank;Joachim Frank

  • Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

    Christian M T Spahn;Christian M T Spahn;Christian M T Spahn;Maria G Gomez-Lorenzo;Maria G Gomez-Lorenzo;Robert A Grassucci;Robert A Grassucci;Rene Jørgensen

  • Structure of a mammalian ryanodine receptor

    Ran Zalk;Oliver B. Clarke;Amédée des Georges;Robert A. Grassucci

  • Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex

    Roland Beckmann;Doryen Bubeck;Doryen Bubeck;Doryen Bubeck;Robert Grassucci;Robert Grassucci;Robert Grassucci;Pawel Penczek;Pawel Penczek;Pawel Penczek

  • Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation

    Rajendra K. Agrawal;Pawel A Penczek;Pawel A Penczek;Robert A. Grassucci;Joachim Frank;Joachim Frank

  • EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome

    Rajendra K. Agrawal;Amy B. Heagle;Amy B. Heagle;Pawel Penczek;Pawel Penczek;Robert A. Grassucci;Robert A. Grassucci

  • Three-dimensional architecture of the calcium channel/foot structure of sarcoplasmic reticulum

    Terence Wagenknecht;Robert Grassucci;Joachim Frank;Akitsugu Saito

  • Structural Basis for Gating and Activation of RyR1.

    Amédée des Georges;Amédée des Georges;Oliver B. Clarke;Ran Zalk;Qi Yuan

  • Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle.

    Michael Radermacher;Vibha Rao;Robert Grassucci;Joachim Frank

  • Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process

    Mikel Valle;Jayati Sengupta;Neil K. Swami;Robert A. Grassucci

  • A 9 Å Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit

    Nenad Ban;Betty Freeborn;Poul Nissen;Pawel Penczek;Pawel Penczek

  • Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes: The IRES Functions as an RNA-Based Translation Factor

    Christian M.T. Spahn;Eric Jan;Anke Mulder;Anke Mulder;Anke Mulder;Robert A. Grassucci;Robert A. Grassucci

  • A cryo-electron microscopic study of ribosome-bound termination factor RF2

    Urmila B. S. Rawat;Andrey V. Zavialov;Jayati Sengupta;Mikel Valle;Mikel Valle

  • Preparation of macromolecular complexes for cryo-electron microscopy.

    Robert A. Grassucci;Derek James Taylor;Joachim Frank;Joachim Frank

  • Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

    Elizabeth Villa;Jayati Sengupta;Jayati Sengupta;Leonardo G. Trabuco;Jamie LeBarron

  • Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome

    Rajendra K. Agrawal;Pawel A Penczek;Robert A. Grassucci;Yanhong Li

Frequent Co-Authors

Joachim Frank
Joachim Frank Columbia University
Pawel A. Penczek
Pawel A. Penczek The University of Texas Health Science Center at Houston
Rajendra K. Agrawal
Rajendra K. Agrawal University at Albany, State University of New York
Christian M. T. Spahn
Christian M. T. Spahn Charité - University Medicine Berlin
Sidney Fleischer
Sidney Fleischer Vanderbilt University
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Knud H. Nierhaus
Knud H. Nierhaus Max Planck Society
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Jonathan A. Javitch
Jonathan A. Javitch Columbia University
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center

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