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Thomas A. Steitz

Thomas A. Steitz

Award Badge
Molecular Biology
USA
2023

D-Index & Metrics

Molecular Biology

D-Index
143
Citations
77423
World Ranking
109
National Ranking
71

Research.com Recognitions

  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2009 - Nobel Prize for studies of the structure and function of the ribosome
  • 2007 - Canada Gairdner International Award
  • 2006 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 1990 - Member of the National Academy of Sciences

Overview

Thomas A. Steitz was affiliated with Yale University in the United States. Their research primarily spanned the fields of Biochemistry, Genetics and Molecular Biology, with contributions also in Medicine and Materials Science.

The main subfields of study included Molecular Biology, Materials Chemistry, Epidemiology, Surgery, and Ecology. Their work covered several key topics such as RNA and protein synthesis mechanisms, RNA modifications and cancer, enzyme structure and function, DNA and nucleic acid chemistry, RNA research and splicing, pneumonia and respiratory infections, and chemical synthesis and analysis.

Selected recent papers authored or co-authored by Steitz are:

  • RNA stabilization by a poly(A) tail 3'-end binding pocket and other modes of poly(A)-RNA interaction, 2021, Science
  • Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation, 2020, iScience
  • Molecular dynamics analysis of Mg2+-dependent cleavage of a pistol ribozyme reveals a fail-safe secondary ion for catalysis, 2020, Journal of Computational Chemistry
  • Crystal structure of the C-terminal domain of DENR, 2020, Computational and Structural Biotechnology Journal

Frequent co-authors across publications with Steitz included:

  • Peter B. Moore
  • Nenad Ban
  • Poul Nissen
  • Jimin Wang
  • Gregor Blaha

Notable venues where Steitz published included:

  • Science
  • iScience
  • Journal of Computational Chemistry
  • Computational and Structural Biotechnology Journal

The awards received by Steitz were:

  • Nobel Prize in 2009 for studies of the structure and function of the ribosome
  • Canada Gairdner International Award in 2007
  • Keio Medical Science Prize, Keio University, Tokyo, Japan, 2006
  • Member of the National Academy of Sciences, 1990

Best Publications

  • The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.

    Nenad Ban;Poul Nissen;Jeffrey L. Hansen;Peter B. Moore

  • The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

    Poul Nissen;Jeffrey Hansen;Nenad Ban;Peter B. Moore

  • Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.

    LA Kohlstaedt;J Wang;JM Friedman;PA Rice

  • Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.

    D M Engelman;T A Steitz;A Goldman

  • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

    L. S. Beese;T. A. Steitz

  • Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees.

    Steve C. Schultz;George C. Shields;Thomas A. Steitz

  • A general two-metal-ion mechanism for catalytic RNA

    Thomas A. Steitz;Joan A. Steitz

  • DNA Polymerases: Structural Diversity and Common Mechanisms

    Thomas A. Steitz

  • Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

    D. L. Ollis;P. Brick;P. Brick;R. Hamlin;N. G. Xuong

  • Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution

    Mark A. Rould;John J. Perona;Dieter Soll;Thomas A. Steitz

  • The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis

    D.M. Engelman;T.A. Steitz

  • The structure of the E. coli recA protein monomer and polymer.

    Randall M. Story;Irene T. Weber;Irene T. Weber;Thomas A. Steitz

  • The kink-turn: a new RNA secondary structure motif.

    D.J. Klein;T.M. Schmeing;P.B. Moore;T.A. Steitz;T.A. Steitz

  • Structure of the recA protein–ADP complex

    Randall M. Story;Thomas A. Steitz

  • Function and structure relationships in DNA polymerases.

    Catherine M. Joyce;Thomas A. Steitz

  • Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA

    David B. McKay;Thomas A. Steitz

  • RNA tertiary interactions in the large ribosomal subunit: the A-minor motif.

    Poul Nissen;Joseph A. Ippolito;Nenad Ban;Peter B. Moore

  • A mechanism for all polymerases

    Thomas A. Steitz

  • The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit

    Jeffrey L. Hansen;Joseph A. Ippolito;Nenad Ban;Poul Nissen

  • Structure of DNA polymerase I Klenow fragment bound to duplex DNA

    Lorena S. Beese;Victoria Derbyshire;Thomas A. Steitz

Frequent Co-Authors

Jimin Wang
Jimin Wang Yale University
Peter B. Moore
Peter B. Moore Yale University
Poul Nissen
Poul Nissen Aarhus University
Nenad Ban
Nenad Ban ETH Zurich
Phoebe A. Rice
Phoebe A. Rice University of Chicago
Paul S. Freemont
Paul S. Freemont Imperial College London
Margarita Salas
Margarita Salas Spanish National Research Council
Donald M. Engelman
Donald M. Engelman Yale University
David L. Ollis
David L. Ollis Australian National University
Dieter Söll
Dieter Söll Yale University

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