World's Best Scientists 2026 revealed!

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Chemistry

D-Index
97
Citations
29991
World Ranking
1487
National Ranking
79

Molecular Biology

D-Index
100
Citations
31342
World Ranking
540
National Ranking
42

Research.com Recognitions

  • 2002 - Fellow of the Royal Society, United Kingdom
  • 1988 - Fellow of the Royal Society of Edinburgh

Overview

David M.J. Lilley is affiliated with the University of Dundee in the United Kingdom and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, particularly focusing on Molecular Biology. Their research encompasses a variety of topics including RNA and protein synthesis mechanisms, RNA modifications and cancer, RNA research and splicing, DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, bacterial genetics and biotechnology, and DNA repair mechanisms.

The scientist has published prolifically, with frequent contributions to several key journals. These include:

  • Nucleic Acids Research
  • Biophysical Journal
  • RNA
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Chemical Biology

Some recent notable papers authored or co-authored by David M.J. Lilley include:

  • "RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers," 2020, RNA
  • "Structure and mechanism of a methyltransferase ribozyme," 2022, Nature Chemical Biology
  • "The potential versatility of RNA catalysis," 2021, Wiley Interdisciplinary Reviews - RNA
  • "Structure and ligand binding of the ADP-binding domain of the NAD+ riboswitch," 2020, RNA
  • "Ribocentre: a database of ribozymes," 2022, Nucleic Acids Research

The scientist has collaborated frequently with other researchers including Lin Huang, Timothy J. Wilson, Xuemei Peng, Artur Kaczmarczyk, and Anne-Cécile Déclais.

David M.J. Lilley's published body of work primarily lies within the subfield of Molecular Biology, supported by four publications in Genetics and minor contributions to Astronomy and Astrophysics, Cancer Research, and Materials Chemistry. They have been recognized with honors such as Fellow of the Royal Society, United Kingdom, awarded in 2002, and Fellow of the Royal Society of Edinburgh, awarded in 1988.

Best Publications

  • DNA replication, 2nd edn

    David Lilley

  • Nucleic Acids and Molecular Biology

    Fritz Eckstein;David M. J. Lilley

  • The inverted repeat as a recognizable structural feature in supercoiled DNA molecules

    David M. J. Lilley

  • The high-resolution crystal structure of a parallel-stranded guanine tetraplex

    Gerard Laughlan;Alastair I. H. Murchie;David G. Norman;Madeleine H. Moore

  • HUMAN MUTSALPHA RECOGNIZES DAMAGED DNA BASE PAIRS CONTAINING O6-METHYLGUANINE, O4-METHYLTHYMINE, OR THE CISPLATIN-D(GPG) ADDUCT

    Derek R. Duckett;James T. Drummond;Alastair I. H. Murchie;Joyce T. Reardon

  • The structure of the holliday junction, and its resolution

    D. R. Duckett;A. I. H. Murchie;S. Diekmann;E. von Kitzing

  • The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution.

    Kathryn Phillips;Zbyszek Dauter;Alastair I.H. Murchie;David M.J. Lilley

  • Structures of helical junctions in nucleic acids.

    David M. J. Lilley

  • Fluorescence energy transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules

    Alastair I. H. Murchie;Robert M. Clegg;Eberhard von Krtzing;Derek R. Duckett

  • Structural dynamics of individual Holliday junctions.

    Sean A. McKinney;Anne Cécile Déclais;David M.J. Lilley;Taekjip Ha

  • Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids

    Asif Iqbal;Sinan Arslan;Burak Okumus;Timothy J. Wilson

  • Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

    Ivan M. Muñoz;Karolina Hain;Anne-Cécile Déclais;Mary Gardiner

  • Observing the helical geometry of double-stranded DNA in solution by fluorescence resonance energy transfer.

    Robert M. Clegg;Alastair I. H. Murchie;Annelies Zechel;David M. J. Lilley

  • Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli.

    E.Lynn Zechiedrich;E.Lynn Zechiedrich;Arkady B. Khodursky;Sophie Bachellier;Robert Schneider

  • Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

    Craig MacKay;Anne-Cécile Déclais;Cecilia Lundin;Ana Agostinho

  • Fluorescence resonance energy transfer analysis of the structure of the four-way DNA junction.

    Robert M. Clegg;Alastair I. H. Murchie;Annelies Zechel;Carsten Carlberg

  • Generation of superhelical torsion by ATP-dependent chromatin remodeling activities.

    Kristina Havas;Andrew Flaus;Michael Phelan;Robert Kingston

  • Folding of the Adenine Riboswitch

    Jean-François Lemay;J. Carlos Penedo;Renaud Tremblay;David M.J. Lilley

  • The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins.

    Marco E. Bianchi;Luca Falciola;Simona Ferrari;David M. Lilley

  • Fluorescence-Force Spectroscopy Maps Two-Dimensional Reaction Landscape of the Holliday Junction

    Sungchul Hohng;Sungchul Hohng;Sungchul Hohng;Ruobo Zhou;Michelle K. Nahas;Jin Yu

Frequent Co-Authors

David Norman
David Norman University of California, San Francisco
Robert M. Clegg
Robert M. Clegg University of Illinois at Urbana-Champaign
Taekjip Ha
Taekjip Ha Johns Hopkins University
Malcolm F. White
Malcolm F. White University of St Andrews
Anton Gartner
Anton Gartner University of Dundee
Simon E. V. Phillips
Simon E. V. Phillips University of Oxford
Fritz Eckstein
Fritz Eckstein Max Planck Society
Joseph A. Piccirilli
Joseph A. Piccirilli University of Chicago
Robert T. Batey
Robert T. Batey University of Colorado Boulder
Paul J. Hagerman
Paul J. Hagerman University of California, Davis

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