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Joseph A. Piccirilli

Joseph A. Piccirilli

D-Index & Metrics

Chemistry

D-Index
57
Citations
11094
World Ranking
11132
National Ranking
3040

Overview

Joseph A. Piccirilli is affiliated with the University of Chicago in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a specific emphasis on Molecular Biology. The scope of their work spans several related subfields including Ecology, Cardiology and Cardiovascular Medicine, Genetics, and Organic Chemistry.

The topics addressed in their research cover a range of areas including:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • Bacteriophages and microbial interactions
  • Genomics and Phylogenetic Studies
  • RNA Research and Splicing

Joseph A. Piccirilli has several frequent coauthors, illustrating collaborative research efforts. These include Nan-Sheng Li, Anna Lewicka, Deepak Koirala, Sunita Maharjan, and Howard Gamper.

Their publications are found in a variety of scientific venues. The most frequent include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Chemical Biology
  • Nature Chemistry
  • Nature Methods
  • Nucleic Acids Research

Among their recent published papers are:

  • The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography, 2021, ACS Chemical Biology
  • Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures, 2020, Nature Chemistry
  • Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme, 2020, Nature Chemistry
  • Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly, 2022, Nature Methods
  • RNA-Puzzles Round V: blind predictions of 23 RNA structures, 2024, Nature Methods

Best Publications

  • Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet

    Joseph A. Piccirilli;Steven A. Benner;Tilman Krauch;Simon E. Moroney

  • Metal ion catalysis in the Tetrahymena ribozyme reaction

    Joseph A. Piccirilli;Joseph S. Vyle;Joseph S. Vyle;Marvin H. Caruthers;Thomas R. Cech

  • Hachimoji DNA and RNA. A Genetic System with Eight Building Blocks

    Shuichi Hoshika;Nicole A. Leal;Myong Jung Kim;Myong Sang Kim

  • RNA catalyses nuclear pre-mRNA splicing

    Sebastian M. Fica;Nicole Tuttle;Thaddeus Novak;Nan-Sheng Li

  • A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.

    Hao Huang;Nikolai B Suslov;Nan-Sheng Li;Sandip A Shelke

  • Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.

    Daniel Herschlag;Joseph A. Piccirilli;Thomas R. Cech

  • Aminoacyl esterase activity of the Tetrahymena ribozyme.

    Joseph A. Piccirilli;Timothy S. McConnell;Arthur J. Zaug;Harry F. Noller

  • General acid catalysis by the hepatitis delta virus ribozyme.

    Subha R Das;Joseph A Piccirilli

  • Synthesis, Properties, and Applications of Oligonucleotides Containing an RNA Dinucleotide Phosphorothiolate Linkage

    Nan-Sheng Li;John K. Frederiksen;Joseph A. Piccirilli

  • Metal ion catalysis during splicing of premessenger RNA

    Erik J. Sontheimer;Sengen Sun;Joseph A. Piccirilli

  • Three metal ions at the active site of the Tetrahymena group I ribozyme

    Shu-ou Shan;Aiichiro Yoshida;Sengen Sun;Joseph A. Piccirilli

  • Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.

    Shu-ou Shan;Alexander V. Kravchuk;Joseph A. Piccirilli;Daniel Herschlag

  • Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.

    Erik J. Sontheimer;Peter M. Gordon;Joseph A. Piccirilli

  • Synthetic antibodies for specific recognition and crystallization of structured RNA

    Jing-Dong Ye;Valentina Tereshko;John K. Frederiksen;Akiko Koide

  • RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.

    T R Cech;D Herschlag;J A Piccirilli;A M Pyle

  • Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.

    Haripriya Ramu;Nora Vázquez-Laslop;Dorota Klepacki;Qing Dai

  • Crystal structure of the catalytic core of an RNA-polymerase ribozyme.

    David M. Shechner;Robert A. Grant;Sarah C. Bagby;Yelena Koldobskaya

  • Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis

    Peter M. Gordon;Joseph A. Piccirilli;Joseph A. Piccirilli

  • Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.

    Peter M. Gordon;Erik J. Sontheimer;Joseph A. Piccirilli

  • The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation

    Louise Scharf;Nan-Sheng Li;Andrew J. Hawk;Diana Garzón

Frequent Co-Authors

Qing Dai
Qing Dai University of Chicago
Daniel Herschlag
Daniel Herschlag Stanford University
Darrin M. York
Darrin M. York Rutgers, The State University of New Jersey
Steven A. Benner
Steven A. Benner University of Florida
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
Shohei Koide
Shohei Koide New York University
David M.J. Lilley
David M.J. Lilley University of Dundee
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School
Phoebe A. Rice
Phoebe A. Rice University of Chicago

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