What is he best known for?
The fields of study he is best known for:
- Enzyme
- DNA
- Organic chemistry
Roland K. O. Sigel mostly deals with Stereochemistry, Ribozyme, Inorganic chemistry, Biochemistry and Metal ions in aqueous solution.
His Stereochemistry research is multidisciplinary, incorporating elements of RNA, Nucleobase, Nucleic acid and Hydrogen bond.
His work focuses on many connections between Ribozyme and other disciplines, such as Group II intron, that overlap with his field of interest in Active site, Molecule and Intron.
His study focuses on the intersection of Inorganic chemistry and fields such as Metal with connections in the field of Ion and Crystallography.
He has researched Biochemistry in several fields, including Flow cytometry and Fluorescence microscope.
His biological study spans a wide range of topics, including Enzyme catalysis, Affinities and Binding site.
His most cited work include:
- Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry (205 citations)
- Solution structure of a DNA double helix with consecutive metal-mediated base pairs (185 citations)
- Metal Ions in Life Sciences (150 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Stereochemistry, RNA, Ribozyme, Metal ions in aqueous solution and Nucleic acid.
His Stereochemistry research includes themes of Nucleobase, Nucleotide, Guanine, Group II intron and Binding site.
His Group II intron study integrates concerns from other disciplines, such as Solution structure and Intron.
His study in RNA is interdisciplinary in nature, drawing from both Nanotechnology, DNA and Förster resonance energy transfer.
The study incorporates disciplines such as Folding, Combinatorial chemistry, RNA splicing and Molecule in addition to Ribozyme.
His work investigates the relationship between Metal ions in aqueous solution and topics such as Crystallography that intersect with problems in Stacking.
He most often published in these fields:
- Stereochemistry (34.43%)
- RNA (28.30%)
- Ribozyme (22.64%)
What were the highlights of his more recent work (between 2015-2021)?
- RNA (28.30%)
- DNA (9.91%)
- Förster resonance energy transfer (7.08%)
In recent papers he was focusing on the following fields of study:
Roland K. O. Sigel mainly focuses on RNA, DNA, Förster resonance energy transfer, Ribozyme and Stereochemistry.
The various areas that he examines in his RNA study include Nucleotide, Binding site and Intron.
His Binding site research incorporates elements of Inorganic chemistry and Metal ions in aqueous solution.
The concepts of his DNA study are interwoven with issues in Molecular biology and Nucleic acid.
The Ribozyme study combines topics in areas such as Group II intron and Protein secondary structure.
His research brings together the fields of Metal and Stereochemistry.
Between 2015 and 2021, his most popular works were:
- G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs (101 citations)
- The Alkali Metal Ions: Their Role for Life (33 citations)
- Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes (17 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- DNA
- Organic chemistry
His primary areas of study are DNA, Förster resonance energy transfer, Nucleic acid, Biophysics and Ribozyme.
His DNA research incorporates themes from Dynamic equilibrium and Nuclear magnetic resonance spectroscopy.
His research in Nucleic acid intersects with topics in Crystallography, Helix, Base pair and Computational biology.
His studies in Biophysics integrate themes in fields like RNA, Biochemistry, Polyethylene glycol and Group II intron.
His RNA study combines topics in areas such as Duplex, Nucleotide and Cofactor.
His Ribozyme study incorporates themes from Native state and Macromolecular crowding.
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