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Roland K. O. Sigel

Roland K. O. Sigel

D-Index & Metrics

Chemistry

D-Index
42
Citations
7035
World Ranking
17485
National Ranking
292

Overview

Roland K. O. Sigel is affiliated with the University of Zurich in Switzerland and has a research portfolio primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans key subfields including Molecular Biology, Biophysics, Oncology, Spectroscopy, and Organic Chemistry.

The research topics addressed by Sigel focus notably on:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • RNA Research and Splicing
  • Advanced Fluorescence Microscopy Techniques
  • Advanced biosensing and bioanalysis techniques
  • Metal complexes synthesis and properties

Sigel has authored several recent papers across well-regarded journals. These include:

  • "A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories" (2022), published in Nature Communications
  • "Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts" (2020), published in Nature Communications
  • "Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks" (2023), published in Journal of the American Chemical Society
  • "Puf6 primes 60S pre-ribosome nuclear export at low temperature" (2021), published in Nature Communications
  • "FRETraj: integrating single-molecule spectroscopy with molecular dynamics" (2021), published in Bioinformatics

Frequent coauthors collaborating with Sigel include Silke Johannsen, Richard Börner, Susann Zelger-Paulus, Mélodie C. A. S. Hadzic, and James S. Craig. These recurring collaborations are indicative of their active role in multidisciplinary teams.

Sigel's research has appeared in various publication venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Methods in molecular biology
  • Zenodo (CERN European Organization for Nuclear Research)
  • CHIMIA International Journal for Chemistry

Best Publications

  • Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry

    Roland K. O. Sigel;Anna Marie Pyle

  • Solution structure of a DNA double helix with consecutive metal-mediated base pairs

    Silke Johannsen;Nicole Megger;Dominik Böhme;Roland K. O. Sigel

  • A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites.

    Roland K. O. Sigel;Helmut Sigel

  • Interrelations between Essential Metal Ions and Human Diseases

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

    Qian Cao;Yi Li;Eva Freisinger;Peter Z. Qin

  • Metal Ions in Life Sciences

    Astrid Sigel;Helmut Sigel;Roland K O Sigel

  • Cadmium : from toxicity to essentiality

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • From nucleotides to ribozymes—A comparison of their metal ion binding properties

    Eva Freisinger;Roland K.O. Sigel

  • Metal ion binding sites in a group II intron core.

    Roland K. O. Sigel;Anand Vaidya;Anand Vaidya;Anna Marie Pyle;Anna Marie Pyle

  • Nickel and its surprising impact in nature

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Controlling ribozyme activity by metal ions

    Joachim Schnabl;Roland K O Sigel

  • Single-molecule studies of group II intron ribozymes.

    Miriam Steiner;Krishanthi S. Karunatilaka;Roland K. O. Sigel;David Rueda

  • STABILITIES AND STRUCTURES OF METAL ION COMPLEXES OF ADENOSINE 5'-O-THIOMONOPHOSPHATE (AMPS2-) IN COMPARISON WITH THOSE OF ITS PARENT NUCLEOTIDE (AMP2 -) IN AQUEOUS SOLUTION

    Roland K O Sigel;Bin Song;Helmut Sigel

  • Photo-induced uncaging of a specific Re( i ) organometallic complex in living cells

    Anna Leonidova;Vanessa Pierroz;Riccardo Rubbiani;Yanjun Lan

  • Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif.

    Roland K O Sigel;Dipali G Sashital;Dana L Abramovitz;Arthur G Palmer

  • Biomineralization : from nature to application

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with cytosine: platinum coordination strengthens the Watson-Crick pair.

    Roland K. O. Sigel;Eva Freisinger;Bernhard Lippert

  • Using in vitro transcription to construct scaffolds for one-dimensional arrays of mercuric ions.

    Silke Johannsen;Susann Paulus;Nicole Düpre;Jens Müller

  • The Ubiquitous Roles of Cytochrome P450 Proteins: Sigel/The Ubiquitous Roles of Cytochrome P450 Proteins

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • The Alkali Metal Ions: Their Role for Life

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Metalated Nucleobase Quartets: Dimerization of a Metal-Modified Guanine, Cytosine Pair of trans-(NH3)2PtII and Formation of CH···N Hydrogen Bonds

    Roland K. O. Sigel;Eva Freisinger;Susanne Metzger;Bernhard Lippert

  • Group II Intron Ribozymes and Metal Ions – A Delicate Relationship

    Roland K. O. Sigel

  • Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction†

    Siriporn Phongtongpasuk;Siriporn Phongtongpasuk;Susann Paulus;Joachim Schnabl;Roland K. O. Sigel

  • Pyrazine as a building block for molecular architectures with PtII.

    Michael Willermann;Clodagh Mulcahy;Roland K. O. Sigel;Marta Morell Cerda

  • The ubiquitous roles of cytochrome P450 proteins

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

Frequent Co-Authors

Helmut Sigel
Helmut Sigel University of Basel
Bernhard Lippert
Bernhard Lippert TU Dortmund University
Anna Marie Pyle
Anna Marie Pyle Yale University
Jens Müller
Jens Müller University of Münster
Bernhard Spingler
Bernhard Spingler University of Zurich
Roger Alberto
Roger Alberto University of Zurich
Christof Holliger
Christof Holliger École Polytechnique Fédérale de Lausanne
Henryk Kozlowski
Henryk Kozlowski University of Wrocław
Michael J. Hannon
Michael J. Hannon University of Birmingham
Gilles Gasser
Gilles Gasser Chimie ParisTech

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