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Roland K. O. Sigel

Roland K. O. Sigel

University of Zurich
Switzerland

D-Index & Metrics

Chemistry

D-Index
42
Citations
7035
World Ranking
17483
National Ranking
293

Roland K. O. Sigel publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Roland K. O. Sigel sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 239 publications — 46th percentile

46% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Roland K. O. Sigel D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Roland K. O. Sigel sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 42 D-Index — 3rd percentile

3% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Roland K. O. Sigel is affiliated with the University of Zurich in Switzerland and has a research portfolio primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans key subfields including Molecular Biology, Biophysics, Oncology, Spectroscopy, and Organic Chemistry.

The research topics addressed by Sigel focus notably on:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • RNA Research and Splicing
  • Advanced Fluorescence Microscopy Techniques
  • Advanced biosensing and bioanalysis techniques
  • Metal complexes synthesis and properties

Sigel has authored several recent papers across well-regarded journals. These include:

  • "A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories" (2022), published in Nature Communications
  • "Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts" (2020), published in Nature Communications
  • "Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks" (2023), published in Journal of the American Chemical Society
  • "Puf6 primes 60S pre-ribosome nuclear export at low temperature" (2021), published in Nature Communications
  • "FRETraj: integrating single-molecule spectroscopy with molecular dynamics" (2021), published in Bioinformatics

Frequent coauthors collaborating with Sigel include Silke Johannsen, Richard Börner, Susann Zelger-Paulus, Mélodie C. A. S. Hadzic, and James S. Craig. These recurring collaborations are indicative of their active role in multidisciplinary teams.

Sigel's research has appeared in various publication venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Methods in molecular biology
  • Zenodo (CERN European Organization for Nuclear Research)
  • CHIMIA International Journal for Chemistry

Best Publications

  • Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry

    Roland K. O. Sigel;Anna Marie Pyle

  • Solution structure of a DNA double helix with consecutive metal-mediated base pairs

    Silke Johannsen;Nicole Megger;Dominik Böhme;Roland K. O. Sigel

  • A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites.

    Roland K. O. Sigel;Helmut Sigel

  • Interrelations between Essential Metal Ions and Human Diseases

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

    Qian Cao;Yi Li;Eva Freisinger;Peter Z. Qin

  • Metal Ions in Life Sciences

    Astrid Sigel;Helmut Sigel;Roland K O Sigel

  • Cadmium : from toxicity to essentiality

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • From nucleotides to ribozymes—A comparison of their metal ion binding properties

    Eva Freisinger;Roland K.O. Sigel

  • Metal ion binding sites in a group II intron core.

    Roland K. O. Sigel;Anand Vaidya;Anand Vaidya;Anna Marie Pyle;Anna Marie Pyle

  • Nickel and its surprising impact in nature

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Controlling ribozyme activity by metal ions

    Joachim Schnabl;Roland K O Sigel

  • Single-molecule studies of group II intron ribozymes.

    Miriam Steiner;Krishanthi S. Karunatilaka;Roland K. O. Sigel;David Rueda

  • STABILITIES AND STRUCTURES OF METAL ION COMPLEXES OF ADENOSINE 5'-O-THIOMONOPHOSPHATE (AMPS2-) IN COMPARISON WITH THOSE OF ITS PARENT NUCLEOTIDE (AMP2 -) IN AQUEOUS SOLUTION

    Roland K O Sigel;Bin Song;Helmut Sigel

  • Photo-induced uncaging of a specific Re( i ) organometallic complex in living cells

    Anna Leonidova;Vanessa Pierroz;Riccardo Rubbiani;Yanjun Lan

  • Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif.

    Roland K O Sigel;Dipali G Sashital;Dana L Abramovitz;Arthur G Palmer

  • Biomineralization : from nature to application

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with cytosine: platinum coordination strengthens the Watson-Crick pair.

    Roland K. O. Sigel;Eva Freisinger;Bernhard Lippert

  • Using in vitro transcription to construct scaffolds for one-dimensional arrays of mercuric ions.

    Silke Johannsen;Susann Paulus;Nicole Düpre;Jens Müller

  • The Ubiquitous Roles of Cytochrome P450 Proteins: Sigel/The Ubiquitous Roles of Cytochrome P450 Proteins

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • The Alkali Metal Ions: Their Role for Life

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

  • Metalated Nucleobase Quartets: Dimerization of a Metal-Modified Guanine, Cytosine Pair of trans-(NH3)2PtII and Formation of CH···N Hydrogen Bonds

    Roland K. O. Sigel;Eva Freisinger;Susanne Metzger;Bernhard Lippert

  • Group II Intron Ribozymes and Metal Ions – A Delicate Relationship

    Roland K. O. Sigel

  • Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction†

    Siriporn Phongtongpasuk;Siriporn Phongtongpasuk;Susann Paulus;Joachim Schnabl;Roland K. O. Sigel

  • Pyrazine as a building block for molecular architectures with PtII.

    Michael Willermann;Clodagh Mulcahy;Roland K. O. Sigel;Marta Morell Cerda

  • The ubiquitous roles of cytochrome P450 proteins

    Astrid Sigel;Helmut Sigel;Roland K. O. Sigel

Frequent Co-Authors

Helmut Sigel
Helmut Sigel University of Basel
Bernhard Lippert
Bernhard Lippert TU Dortmund University
Anna Marie Pyle
Anna Marie Pyle Yale University
Jens Müller
Jens Müller University of Münster
Bernhard Spingler
Bernhard Spingler University of Zurich
Roger Alberto
Roger Alberto University of Zurich
Christof Holliger
Christof Holliger École Polytechnique Fédérale de Lausanne
Henryk Kozlowski
Henryk Kozlowski University of Wrocław
Michael J. Hannon
Michael J. Hannon University of Birmingham
Gilles Gasser
Gilles Gasser Chimie ParisTech

External Links

Personal website of Roland K. O. Sigel

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Best Scientists Citing Roland K. O. Sigel

Jens Müller

Jens Müller

University of Münster

Publications: 74

Juewen Liu

Juewen Liu

University of Waterloo

Publications: 72

Bernhard Lippert

Bernhard Lippert

TU Dortmund University

Publications: 57

Anna Marie Pyle

Anna Marie Pyle

Yale University

Publications: 43

Helmut Sigel

Helmut Sigel

University of Basel

Publications: 37

Akira Ono

Akira Ono

Kanagawa University

Publications: 24

Gilles Gasser

Gilles Gasser

Chimie ParisTech

Publications: 23

Darrin M. York

Darrin M. York

Rutgers, The State University of New Jersey

Publications: 17

Mitsuhiko Shionoya

Mitsuhiko Shionoya

University of Tokyo

Publications: 17

Célia Fonseca Guerra

Célia Fonseca Guerra

Vrije Universiteit Amsterdam

Publications: 16

Joseph A. Piccirilli

Joseph A. Piccirilli

University of Chicago

Publications: 16

Jiří Šponer

Jiří Šponer

Masaryk University

Publications: 14

Sandeep Verma

Sandeep Verma

Indian Institute of Technology Kanpur

Publications: 14

Antonín Holý

Antonín Holý

Czech Academy of Sciences

Publications: 13

Zong-Wan Mao

Zong-Wan Mao

Sun Yat-sen University

Publications: 13

Michael Harris

Michael Harris

University of Florida

Publications: 11

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