Senthil K. Muthuswamy

Overview

Best Publications

• Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

  Jayanta Debnath;Senthil K. Muthuswamy;Senthil K. Muthuswamy;Joan S. Brugge

  2379
  Citations

• The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

  Jayanta Debnath;Kenna R. Mills;Nicole L. Collins;Mauricio J. Reginato

  945
  Citations

• ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

  Senthil K. Muthuswamy;Dongmei Li;Sophie Lelievre;Sophie Lelievre;Sophie Lelievre;Mina J. Bissell;Mina J. Bissell

  815
  Citations

• Epidermal Growth Factor Receptor (HER1) Tyrosine Kinase Inhibitor ZD1839 (Iressa) Inhibits HER2/neu (erbB2)-overexpressing Breast Cancer Cells in Vitro and in Vivo

  Stacy L. Moulder;F. Michael Yakes;Senthil K. Muthuswamy;Roberto Bianco

  718
  Citations

• Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

  Ling Huang;Audrey Holtzinger;Ishaan Jagan;Michael Begora

  704
  Citations

• Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis.

  Mauricio J. Reginato;Kenna R. Mills;Jessica K. Paulus;Danielle K. Lynch

  660
  Citations

• HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.

  Shizhen Emily Wang;Archana Narasanna;Marianela Perez-Torres;Bin Xiang

  557
  Citations

• Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

  Lixing Zhan;Avi Rosenberg;Avi Rosenberg;Kenneth C. Bergami;Min Yu

  517
  Citations

• Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers

  Senthil K. Muthuswamy;Michael Gilman;Joan S. Brugge

  480
  Citations

• The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

  Olga Anczuków;Avi Z Rosenberg;Avi Z Rosenberg;Martin Akerman;Shipra Das;Shipra Das

  463
  Citations

• Targeting the disordered C-terminus of PTP1B with an allosteric inhibitor

  Navasona Krishnan;Dorothy Koveal;Daniel H Miller;Bin Xue

  419
  Citations

• Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

  Victoria Aranda;Teresa Haire;Teresa Haire;Marissa E. Nolan;Marissa E. Nolan;Joseph P. Calarco;Joseph P. Calarco

  316
  Citations

• Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

  S K Muthuswamy;P M Siegel;D L Dankort;M A Webster

  305
  Citations

• Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells

  Sarah E. Seton-Rogers;Yu Lu;Lisa M. Hines;Malvika Koundinya

  301
  Citations

• Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

  Xiangpeng Dai;Wenjian Gan;Xiaoning Li;Xiaoning Li;Shangqian Wang

  272
  Citations

• Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice

  Chantale T. Guy;Senthil K. Muthuswamy;Robert Cardiff;Philippe Soriano

  272
  Citations

• A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells

  Ingrid Ibarra;Yaniv Erlich;Senthil K. Muthuswamy;Ravi Sachidanandam

  268
  Citations

• Requirement for both Shc and Phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

  Marc A. Webster;John N. Hutchinson;Michael J. Rauh;Senthil K. Muthuswamy

  253
  Citations

• ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis

  William M. Keyes;Matteo Pecoraro;Victoria Aranda;Emma Vernersson-Lindahl

  223
  Citations

• Abstract PR01: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids

  Senthil K. Muthuswamy

  0
  Citations