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Best Female Scientists
2025
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Molecular Biology
USA
2026

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Best Female Scientists

D-Index
136
Citations
69767
World Ranking
273
National Ranking
171

Molecular Biology

D-Index
137
Citations
70387
World Ranking
142
National Ranking
92

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Female Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Member of the National Academy of Sciences
  • 2000 - Fellow of the American Academy of Arts and Sciences

Overview

Joan S. Brugge is affiliated with Harvard University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a focus on Molecular Biology, Oncology, Cancer Research, Radiology, Nuclear Medicine and Imaging, and Genetics.

The scientist's work encompasses multiple topics including:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Single-cell and spatial transcriptomics
  • HER2/EGFR in Cancer Research
  • Epigenetics and DNA Methylation
  • Monoclonal and Polyclonal Antibodies Research
  • PARP inhibition in cancer therapy

Joan S. Brugge has published extensively in several venues, with a notable frequency in the following journals and archives:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Reports
  • Nature Genetics

Frequent co-authors in their collaborations are:

  • Laura M. Selfors
  • Dennis J. Slamon
  • Jason J. Zoeller
  • G. Kenneth Gray
  • Nomeda Girnius

Recent publications include:

  • Cycling cancer persister cells arise from lineages with distinct programs, 2021, Nature
  • Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer, 2022, Nature reviews. Cancer
  • Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages, 2020, Nature Communications
  • Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids, 2021, Nature Protocols
  • Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer, 2020, Molecular Cell

Joan S. Brugge has been recognized with several awards including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2007
  • Member of the National Academy of Sciences, 2001
  • Fellow of the American Academy of Arts and Sciences, 2000

Best Publications

  • Integrins and signal transduction pathways: the road taken

    Edwin A. Clark;Joan S. Brugge

  • CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

    Sheila M. Thomas;Joan S. Brugge

  • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

    Jayanta Debnath;Senthil K. Muthuswamy;Senthil K. Muthuswamy;Joan S. Brugge

  • Modelling glandular epithelial cancers in three-dimensional cultures.

    Jayanta Debnath;Joan S. Brugge

  • Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.

    M. Rozakis-Adcock;J. McGlade;G. Mbamalu;G. Pelicci

  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  • A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

    Xiao Jun Ma;Zuncai Wang;Paula D. Ryan;Steven J. Isakoff

  • Identification of a transformation-specific antigen induced by an avian sarcoma virus.

    Joan S. Brugge;R. L. Erikson

  • Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment

    Zachary T. Schafer;Alexandra R. Grassian;Loling Song;Zhenyang Jiang

  • Sensing the environment: a historical perspective on integrin signal transduction.

    Cindy K. Miranti;Joan S. Brugge

  • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

    Michael Overholtzer;Jianmin Zhang;Gromoslaw A. Smolen;Beth Muir

  • Signal Transduction in Cancer

    Richard Sever;Joan S. Brugge

  • Engineering tumors with 3D scaffolds.

    Claudia Fischbach;Claudia Fischbach;Ruth Chen;Takuya Matsumoto;Tobias Schmelzle

  • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

    Jayanta Debnath;Kenna R. Mills;Nicole L. Collins;Mauricio J. Reginato

  • Mutant p53 Drives Invasion by Promoting Integrin Recycling

    Patricia A.J. Muller;Patrick T. Caswell;Brendan Doyle;Marcin P. Iwanicki

  • Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

    L Lipfert;B Haimovich;M D Schaller;B S Cobb

  • Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

    Sheila M. Thomas;Michael DeMarco;Gabriella D'Arcangelo;Simon Halegoua

  • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

    Senthil K. Muthuswamy;Dongmei Li;Sophie Lelievre;Sophie Lelievre;Sophie Lelievre;Mina J. Bissell;Mina J. Bissell

  • Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

    Edwin A. Clark;Warren G. King;Joan S. Brugge;Marc Symons

  • Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    J. Locasale;J. Locasale;Alexandra Grassian;Rameen Beroukhim;Matthew Langer Meyerson

Frequent Co-Authors

Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Michael Overholtzer
Michael Overholtzer Memorial Sloan Kettering Cancer Center
Sanford J. Shattil
Sanford J. Shattil University of California, San Diego
Tan A. Ince
Tan A. Ince Cornell University
Senthil K. Muthuswamy
Senthil K. Muthuswamy Beth Israel Deaconess Medical Center
Ronny Drapkin
Ronny Drapkin University of Pennsylvania
Raymond L. Erikson
Raymond L. Erikson Harvard University
Ursula A. Matulonis
Ursula A. Matulonis Harvard University
Marc S. Collett
Marc S. Collett Takeda (United States)
Michael F. Press
Michael F. Press University of Southern California

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