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William J. Muller

William J. Muller

D-Index & Metrics

Medicine

D-Index
107
Citations
42984
World Ranking
6244
National Ranking
246

Research.com Recognitions

  • 2011 - Fellow of the Royal Society of Canada Academy of Science
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

William J. Muller is a researcher affiliated with McGill University in Canada, with a focus on biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields, including molecular biology, oncology, immunology, cancer research, and genetics.

The scientist's research topics concentrate on the biological mechanisms and treatment approaches related to cancer. Major areas of study include:

  • Cancer Cells and Metastasis
  • HER2/EGFR in Cancer Research
  • RNA modifications and cancer
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Genomics and Chromatin Dynamics
  • Cancer, Lipids, and Metabolism

Some of the recent notable papers authored by William J. Muller and collaborators consist of:

  • Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo (2020, Oncogene)
  • The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer (2023, Immunity)
  • ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation (2022, Nature Communications)
  • Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels (2021, Proceedings of the National Academy of Sciences)
  • Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer (2020, Clinical Cancer Research)

The primary publication venues where this scientist frequently publishes include:

  • Cancer Research
  • Oncogene
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Cell Reports

Collaboration is a significant component of their work, as reflected by recurrent co-authors such as Virginie Sanguin-Gendreau, Morag Park, Sherif Samer Attalla, Dongmei Zuo, and Tarek Taifour.

William J. Muller has received recognition in the scientific community through awards such as:

  • Fellow of the Royal Society of Canada (2011, Academy of Science)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2010)
  • Member of the Association of American Physicians

Best Publications

  • Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

    Chantale T. Guy;Robert D. Cardiff;William J. Muller

  • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

    Chantale T. Guy;Marc A. Webster;Michael Schaller;Thomas J. Parsons

  • Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

    William J. Muller;Eric Sinn;Paul K. Pattengale;Racheal Wallace

  • Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

    Elaine Y. Lin;Joan G. Jones;Ping Li;Liyin Zhu

  • Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19.

    Adarsh Bhimraj;Rebecca L. Morgan;Amy Hirsch Shumaker;Valery Lavergne

  • Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo.

    Eric Sinn;William Muller;Paul Pattengale;Isidore Tepler;Isidore Tepler

  • Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

    Krushna C. Patra;Qi Wang;Prashanth T. Bhaskar;Luke Miller

  • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

    Jer Yen Yang;Cong S. Zong;Weiya Xia;Hirohito Yamaguchi

  • Suppression of tumor growth and metastasis in Mgat5-deficient mice.

    Maria Granovsky;Maria Granovsky;Jimmie Fata;Judy Pawling;William J. Muller

  • Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.

    Peter M. Siegel;Eamonn D. Ryan;Robert D. Cardiff;William J. Muller

  • Oncogenes and Tumor Suppressor Genes

    Eva Y.H.P. Lee;William J. Muller

  • β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis

    Wenjun Guo;Yuliya Pylayeva;Yuliya Pylayeva;Angela Pepe;Toshiaki Yoshioka

  • Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

    Peter M. Siegel;Weiping Shu;Robert D. Cardiff;William J. Muller

  • Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

    Donald E. White;Natasza A. Kurpios;Dongmei Zuo;John A. Hassell

  • Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

    Shuying Liu;Makiko Umezu-Goto;Mandi Murph;Yiling Lu

  • Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.

    Richard J. Lee;Chris Albanese;Maofu Fu;Mark D'Amico

  • Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo ROLE OF CAV-1 IN CELL INVASIVENESS AND MATRIX METALLOPROTEINASE (MMP-2/9) SECRETION

    Terence M. Williams;Freddy Medina;Ines Badano;Rachel B. Hazan

  • The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.

    R L Dillon;D E White;W J Muller

  • Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

    Sofi G Julien;Nadia Dubé;Nadia Dubé;Michelle Read;Janice Penney

  • Insights from transgenic mouse models of ERBB2-induced breast cancer

    Josie Ursini-Siegel;Babette Schade;Robert D. Cardiff;William J. Muller

Frequent Co-Authors

Robert D. Cardiff
Robert D. Cardiff University of California, Davis
Morag Park
Morag Park McGill University
Peter M. Siegel
Peter M. Siegel McGill University
Frank L. Graham
Frank L. Graham McMaster University
Senthil K. Muthuswamy
Senthil K. Muthuswamy Beth Israel Deaconess Medical Center
Shoukat Dedhar
Shoukat Dedhar University of British Columbia
John A. Hassell
John A. Hassell McMaster University
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Vincent Giguère
Vincent Giguère McGill University
Robert G. Oshima
Robert G. Oshima Sanford Burnham Prebys Medical Discovery Institute

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