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John A. Hassell

John A. Hassell

D-Index & Metrics

Molecular Biology

D-Index
55
Citations
9776
World Ranking
2283
National Ranking
73

Overview

John A. Hassell is affiliated with McMaster University in Canada and conducts research primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work focuses significantly on oncology, psychiatry and mental health, and molecular biology as subfields.

The scientist's research centers on topics related to cancer cells and metastasis, cancer-related stress, anesthesia, immune response, and the PI3K/AKT/mTOR signaling pathway in cancer. These areas reflect an interest in cellular mechanisms and pathways influencing cancer development and progression.

Recent publications by Hassell include:

  • Antagonists of the serotonin receptor 5A target human breast tumor initiating cells, 2020, BMC Cancer
  • The Role of Serotonin in Breast Cancer Stem Cells, 2021, Molecules

These papers explore the role of serotonin receptors and related signaling in breast cancer stem cells, contributing to the understanding of cancer cell biology.

Frequent coauthors in Hassell's recent work include:

  • William D. Gwynne
  • Mirza S. Shakeel
  • Adele Girgis-Gabardo
  • Kwang H. Kim
  • Emily S. Ford

Their research findings have been published predominantly in the journals BMC Cancer and Molecules, each hosting at least one of their recent contributions.

Best Publications

  • Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

    Eleftherios Sachlos;Ruth M. Risueño;Sarah Laronde;Zoya Shapovalova

  • Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

    Donald E. White;Natasza A. Kurpios;Dongmei Zuo;John A. Hassell

  • Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

    Ji-Hou Xin;Alison Cowie;Paul Lachance;John A. Hassell

  • Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

    N Dyson;R Bernards;S H Friend;L R Gooding

  • ERM is required for transcriptional control of the spermatogonial stem cell niche

    Chen Chen;Wenjun Ouyang;Vadim Grigura;Qing Zhou

  • A novel method to map transcripts: evidence for homology between an adenovirus mRNA and discrete multiple regions of the viral genome.

    Ashley R. Dunn;John A. Hassell

  • The transactivator proteins VP16 and GAL4 bind replication factor A

    Zhigang He;Bradford T. Brinton;Jack Greenblatt;John A. Hassell

  • Deformation and Fracture of High Polymers

    H. Henning Kausch;John A. Hassell;Robert I. Jaffee

  • Requirement for both Shc and Phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

    Marc A. Webster;John N. Hutchinson;Michael J. Rauh;Senthil K. Muthuswamy

  • Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.

    Benson C Lu;Cristina Cebrian;Xuan Chi;Satu Kuure

  • HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer.

    Christopher C. Benz;Ronan C. O'Hagan;Birgit Richter;Gary K. Scott

  • The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

    Howard C. Crawford;Barbara Fingleton;Mark D. Gustavson;Natasza Kurpios

  • THE ACTIVITY OF THE ETS TRANSCRIPTION FACTOR PEA3 IS REGULATED BY TWO DISTINCT MAPK CASCADES

    R C O'Hagan;R G Tozer;M Symons;F McCormick

  • Claudin-Low Breast Cancer; Clinical & Pathological Characteristics

    Kay Dias;Anna Dvorkin-Gheva;Robin M. Hallett;Ying Wu

  • PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2.

    Louise R. Howe;Howard C. Crawford;Kotha Subbaramaiah;Kotha Subbaramaiah;John A. Hassell

  • Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.

    Dylan R. Edwards;Hélène Rocheleau;Renu R. Sharma;Alan J. Wills

  • The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

    Trevor G. Shepherd;Lisa Kockeritz;Michelle R. Szrajber;William J. Muller

  • FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.

    Zhen Zhang;Jamie M. Verheyden;John A. Hassell;Xin Sun

  • Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene

    Victoria L. Bautch;Sachiko Toda;John A. Hassell;Douglas Hanahan

  • Polyomavirus origin for DNA replication comprises multiple genetic elements.

    W J Muller;C R Mueller;A M Mes;J A Hassell

Frequent Co-Authors

William J. Muller
William J. Muller McGill University
Gregory R. Pond
Gregory R. Pond McMaster University
Igor Jurisica
Igor Jurisica University Health Network
Mark Levine
Mark Levine McMaster University
Eric D. Brown
Eric D. Brown McMaster University
Donald N. Cook
Donald N. Cook National Institutes of Health
Jonathan L. Bramson
Jonathan L. Bramson McMaster University
Mickie Bhatia
Mickie Bhatia McMaster University
Amit Sharma
Amit Sharma Microsoft (United States)
Silvia Arber
Silvia Arber University of Basel

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