World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
23911
World Ranking
1351
National Ranking
685

Overview

Melvin L. DePamphilis is affiliated with the National Institutes of Health in the United States, contributing extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans multiple subfields including Molecular Biology, Oncology, Epidemiology, Cell Biology, and Infectious Diseases.

The scientist's main topics of investigation include:

  • Pluripotent Stem Cells Research
  • Cancer-related Molecular Pathways
  • Autophagy in Disease and Therapy
  • CRISPR and Genetic Engineering
  • Endoplasmic Reticulum Stress and Disease
  • Ubiquitin and Proteasome Pathways
  • Renal and Related Cancers

Melvin L. DePamphilis has published multiple papers in notable venues. Recent publications include:

  • "Cell cycle arrest and apoptosis are not dependent on p53 prior to p53-dependent embryonic stem cell differentiation," 2020, Stem Cells
  • "Developmental Acquisition of p53 Functions," 2021, Genes
  • "PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19," 2022, Communications Biology
  • "Cell Death and the p53 Enigma During Mammalian Embryonic Development," 2022, Stem Cells
  • "PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells," 2023, Autophagy

Frequent co-authors collaborating with Melvin L. DePamphilis include:

  • Sushil Kumar Jaiswal
  • Arup Chakraborty
  • Ajit Roy
  • Sonam Raj
  • John J. Oh

The scientist regularly publishes in established journals such as:

  • Stem Cells
  • Cells
  • Molecular Oncology
  • Genes
  • Communications Biology

The research contributions of Melvin L. DePamphilis focus on understanding the molecular mechanisms governing pluripotent stem cells and cancer-related pathways, as well as investigating cellular processes like autophagy and genetic engineering techniques such as CRISPR. Their work addresses complex biological systems involving stress responses in the endoplasmic reticulum and the regulation of protein degradation via ubiquitin and proteasome pathways. Several studies explore cellular differentiation, apoptosis, and viral replication inhibition, highlighting the breadth of their research interests within molecular and cellular biology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

    Alex Vassilev;Kotaro J. Kaneko;Hongjun Shu;Yingming Zhao

  • Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.

    Rieko Yagi;Matthew J. Kohn;Irina Karavanova;Kotaro J. Kaneko

  • Transcriptional elements as components of eukaryotic origins of DNA replication

    Melvin L. DePamphilis

  • Eukaryotic DNA Replication: Anatomy of An Origin

    Melvin L. DePamphilis

  • Identifying 5-methylcytosine and related modifications in DNA genomes

    Theo Rein;Melvin L. DePamphilis;Haralabos Zorbas

  • Guide to techniques in mouse development

    Paul M. Wassarman;Melvin L. DePamphilis

  • Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region

    Ronald T. Hay;Melvin L. Depamphilis

  • Replication origins in metazoan chromosomes: fact or fiction?

    Melvin L. DePamphilis

  • Origins of DNA replication in metazoan chromosomes.

    M L DePamphilis

  • DNA replication in eukaryotic cells

    Melvin L. DePamphilis

  • Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors

    Pallavi Bhattaram;Alfredo Penzo-Méndez;Elisabeth Sock;Clemencia Colmenares

  • Regulating the licensing of DNA replication origins in metazoa

    Melvin L DePamphilis;J Julian Blow;Soma Ghosh;Tapas Saha

  • Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.

    Hans Krokan;Priscilla Schaffer;Melvin L. DePamphilis

  • The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication.

    Melvin L DePamphilis

  • Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.

    Zakir Ullah;Matthew J. Kohn;Rieko Yagi;Lyubomir T. Vassilev

  • Identification of Primary Initiation Sites for DNA Replication in the Hamster Dihydrofolate Reductase Gene Initiation Zone

    Takehiko Kobayashi;Theo Rein;Melvin L. DePamphilis

  • Requirements for promoter activity in mouse oocytes and embryos distinguish paternal pronuclei from maternal and zygotic nuclei

    Maria Wiekowski;Miriam Miranda;Melvin L. DePamphilis

  • Mammalian Orc1 Protein Is Selectively Released from Chromatin and Ubiquitinated during the S-to-M Transition in the Cell Division Cycle

    Cong-Jun Li;Melvin L. DePamphilis

  • EUKARYOTIC CHROMOSOMES: A CLOSE-UP OF THE REPLICATION FORK!

    Melvin L. DePamphilis;Paul M Wassarman

Frequent Co-Authors

Paul M. Wassarman
Paul M. Wassarman Icahn School of Medicine at Mount Sinai
Theo Rein
Theo Rein Max Planck Society
Crisanto Gutierrez
Crisanto Gutierrez Spanish National Research Council
José M. Sogo
José M. Sogo ETH Zurich
Yingming Zhao
Yingming Zhao University of Chicago
J. Julian Blow
J. Julian Blow University of East Anglia
Marc Ferrer
Marc Ferrer National Institutes of Health
David M. Gilbert
David M. Gilbert Florida State University
Juan S. Bonifacino
Juan S. Bonifacino National Institutes of Health
Jonathan Leis
Jonathan Leis Northwestern University

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