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Molecular Biology

D-Index
60
Citations
11582
World Ranking
1976
National Ranking
68

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Marcel Méchali is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology, Genetics, Ecology, and Cell Biology.

The scientist's research topics cover areas including DNA Repair Mechanisms, Genomics and Chromatin Dynamics, Epigenetics and DNA Methylation, RNA and protein synthesis mechanisms, DNA and Nucleic Acid Chemistry, Evolution and Genetic Dynamics, and Bacteriophages and microbial interactions.

Notable recent publications include:

  • A predictable conserved DNA base composition signature defines human core DNA replication origins (2020, Nature Communications)
  • The genetic landscape of origins of replication in P. falciparum (2023, Nucleic Acids Research)
  • Loss of Ezh2 function remodels the DNA replication initiation landscape (2023, Cell Reports)
  • Mitosis without DNA replication in mammalian somatic cells (2020, bioRxiv - Cold Spring Harbor Laboratory)
  • Author Correction: Involvement of G-quadruplex regions in mammalian replication origin activity (2020, Nature Communications)

Marcel Méchali has collaborated frequently with several co-authors, including:

  • Isabelle Peiffer
  • Paulina Prorok
  • İldem Akerman
  • Marie Artufel
  • Charles Theillet

Their research has been published in key venues such as Nature Communications, Cell Reports, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, and Science.

Marcel Méchali is a member of the European Molecular Biology Organization (EMBO), an affiliation that reflects professional recognition in their scientific community.

Best Publications

  • Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

    Shusuke Tada;Anatoliy Li;Domenico Maiorano;Marcel Méchali

  • DNA replication origin activation in space and time

    Michalis Fragkos;Olivier Ganier;Philippe Coulombe;Marcel Méchali

  • Eukaryotic DNA replication origins: many choices for appropriate answers

    Marcel Méchali

  • XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

    Domenico Maiorano;Jacques Moreau;Marcel Méchali

  • Transition in Specification of Embryonic Metazoan DNA Replication Origins

    Olivier Hyrien;Chrystelle Maric;Marcel Méchali

  • Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features

    Christelle Cayrou;Philippe Coulombe;Alice Vigneron;Slavica Stanojcic

  • MCM proteins and DNA replication

    Domenico Maiorano;Malik Lutzmann;Marcel Méchali

  • DNA Replication Origins

    Alan C. Leonard;Marcel Méchali

  • Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.

    O. Hyrien;M. Méchali

  • Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53.

    Soussi T;Caron de Fromentel C;Méchali M;May P

  • Lack of specific sequence requirement for DNA replication in Xenopus eggs compared with high sequence specificity in yeast.

    Marcel Méchali;Marcel Méchali;Stephen Kearsey;Stephen Kearsey

  • MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination

    Malik Lutzmann;Corinne Grey;Sabine Traver;Olivier Ganier

  • Mitotic Remodeling of the Replicon and Chromosome Structure

    Jean-Marc Lemaitre;Etienne Danis;Philippe Pasero;Yegor Vassetzky

  • New insights into replication origin characteristics in metazoans.

    Christelle Cayrou;Philippe Coulombe;Aurore Puy;Stéphanie Rialle

  • Specification of a DNA replication origin by a transcription complex

    Etienne Danis;Konstantin Brodolin;Sophie Menut;Domenico Maiorano

  • MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation

    Domenico Maiorano;Olivier Cuvier;Etienne Danis;Marcel Méchali

  • Competition between chromatin and transcription complex assembly regulates gene expression during early development

    Marie-Noëlle Prioleau;Janine Huet;André Sentenac;Marcel Méchali

  • The chromatin environment shapes DNA replication origin organization and defines origin classes

    Christelle Cayrou;Benoit Ballester;Benoit Ballester;Isabelle Peiffer;Romain Fenouil

  • DNA replication origins: from sequence specificity to epigenetics

    Marcel Méchali

  • Genetic and epigenetic determinants of DNA replication origins, position and activation.

    Marcel Méchali;Kazumasa Yoshida;Philippe Coulombe;Philippe Pasero

Frequent Co-Authors

Thierry Soussi
Thierry Soussi Université Paris Cité
Geneviève Almouzni
Geneviève Almouzni Institute Curie
Philippe Pasero
Philippe Pasero Centre national de la recherche scientifique, CNRS
André Sentenac
André Sentenac French Alternative Energies and Atomic Energy Commission (CEA)
Charles Theillet
Charles Theillet University of Montpellier
Marie-Paule Teulade-Fichou
Marie-Paule Teulade-Fichou University of Paris-Saclay
Jacques van Helden
Jacques van Helden Aix-Marseille University
Baek Kim
Baek Kim Emory University
Claude Sardet
Claude Sardet University of Montpellier

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