Member of the European Molecular Biology Organization (EMBO)
His primary areas of investigation include DNA replication, Origin recognition complex, Control of chromosome duplication, Genetics and Pre-replication complex. The various areas that Marcel Méchali examines in his DNA replication study include Molecular biology, Xenopus and Plasmid. In Molecular biology, Marcel Méchali works on issues like Chromatin, which are connected to TATA-Box Binding Protein, TAF2 and TATA-binding protein.
His Origin recognition complex research is multidisciplinary, incorporating perspectives in Licensing factor and Cell biology. His research on Control of chromosome duplication focuses in particular on Replication factor C. His study in Pre-replication complex is interdisciplinary in nature, drawing from both DNA replication factor CDT1 and DNA re-replication.
DNA replication, Cell biology, Molecular biology, Genetics and Origin recognition complex are his primary areas of study. The concepts of his DNA replication study are interwoven with issues in Cell cycle and DNA synthesis. His Cell biology research includes elements of Chromatin and Xenopus.
His Molecular biology study integrates concerns from other disciplines, such as Replication Initiation, Midblastula, Somatic cell and DNA polymerase. His Origin recognition complex research integrates issues from Control of chromosome duplication, Pre-replication complex, DNA replication origin, Licensing factor and DNA re-replication. His work on DNA replication factor CDT1 and Replication factor C as part of general Control of chromosome duplication study is frequently linked to Replication protein A, therefore connecting diverse disciplines of science.
Marcel Méchali mainly focuses on DNA replication, Genetics, Cell biology, Control of chromosome duplication and Origin recognition complex. His DNA replication study frequently intersects with other fields, such as Chromatin. His research in Chromatin intersects with topics in Xenopus, Molecular biology, Homologous recombination and DNA repair.
The study incorporates disciplines such as Enhancer and G-quadruplex in addition to Cell biology. His Eukaryotic DNA replication research extends to Control of chromosome duplication, which is thematically connected. His research investigates the connection between Origin recognition complex and topics such as Licensing factor that intersect with issues in Interkinesis and Meiosis II.
The scientist’s investigation covers issues in Genetics, DNA replication, Origin recognition complex, Pre-replication complex and Control of chromosome duplication. His study brings together the fields of Cancer research and Genetics. He studies Origin of replication, a branch of DNA replication.
The Origin recognition complex study combines topics in areas such as Chromatin and DNA replication origin. His studies deal with areas such as Cell biology, DNA replication factor CDT1 and DNA re-replication as well as Pre-replication complex. He works mostly in the field of Cell biology, limiting it down to topics relating to S phase and, in certain cases, MCM Protein Complex and G2 phase.
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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
Shusuke Tada;Anatoliy Li;Domenico Maiorano;Marcel Méchali.
Nature Cell Biology (2001)
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
Domenico Maiorano;Jacques Moreau;Marcel Méchali.
Eukaryotic DNA replication origins: many choices for appropriate answers
Nature Reviews Molecular Cell Biology (2010)
DNA replication origin activation in space and time
Michalis Fragkos;Olivier Ganier;Philippe Coulombe;Marcel Méchali.
Nature Reviews Molecular Cell Biology (2015)
Transition in Specification of Embryonic Metazoan DNA Replication Origins
Olivier Hyrien;Chrystelle Maric;Marcel Méchali.
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features
Christelle Cayrou;Philippe Coulombe;Alice Vigneron;Slavica Stanojcic.
Genome Research (2011)
MCM proteins and DNA replication
Domenico Maiorano;Malik Lutzmann;Marcel Méchali.
Current Opinion in Cell Biology (2006)
Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.
O. Hyrien;M. Méchali.
The EMBO Journal (1993)
Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53.
Soussi T;Caron de Fromentel C;Méchali M;May P.
DNA Replication Origins
Alan C. Leonard;Marcel Méchali.
Cold Spring Harbor Perspectives in Biology (2013)
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