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Molecular Biology

D-Index
54
Citations
10835
World Ranking
2322
National Ranking
1145

Overview

Mirit I. Aladjem is affiliated with the National Institutes of Health in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, oncology, cancer research, epidemiology, and pulmonary and respiratory medicine.

The primary topics of their work include:

  • DNA Repair Mechanisms
  • Lung Cancer Research Studies
  • Cancer Genomics and Diagnostics
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer

They have contributed research papers published in a variety of scientific venues, prominently including Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Cancer Research, Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), and Molecular and Cellular Biology.

Some of their recent notable publications are:

  • "CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics," 2020, Nucleic Acids Research
  • "Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress," 2021, Cancer Cell
  • "SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures," 2020, Cell Reports
  • "A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells," 2020, eLife
  • "Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes," 2023, Cancer Discovery

The scientist works frequently with several co-authors, including Christophe E. Redon, Yves Pommier, Lőrinc Sándor Pongor, Haiqing Fu, and Anish Thomas. Their collaboration with these colleagues is reflected in numerous joint publications.

Mirit I. Aladjem's body of work reflects a significant contribution to understanding cancer biology, particularly lung cancer, at the molecular and genomic levels. Their research also focuses on mechanisms of DNA repair, chromatin dynamics, and RNA biology, linking molecular processes to disease pathology and therapeutic approaches.

Best Publications

  • The Systems Biology Graphical Notation

    Nicolas Le Novere;Michael Hucka;Huaiyu Mi;Stuart Moodie

  • The BioPAX community standard for pathway data sharing

    Emek Demir;Emek Demir;Michael P. Cary;Suzanne Paley;Ken Fukuda

  • Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes

    Takahisa Furuta;Haruyuki Takemura;Zhi Yong Liao;Gregory J. Aune

  • ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

    Mirit I. Aladjem;Benjamin T. Spike;Luo Wei Rodewald;Thomas J. Hope

  • Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

    Mirit I. Aladjem;Mark Groudine;Linnea L. Brody;Ellen S. Dieken

  • Genetic Dissection of a Mammalian Replicator in the Human β-Globin Locus

    Mirit I. Aladjem;Luo Wei Rodewald;John L. Kolman;Geoffrey M. Wahl

  • The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses

    Jennifer A. Seiler;Chiara Conti;Ali Syed;Mirit I. Aladjem

  • Replication in context: dynamic regulation of DNA replication patterns in metazoans

    Mirit I. Aladjem

  • SLFN11 Blocks Stressed Replication Forks Independently of ATR

    Junko Murai;Sai-Wen Tang;Elisabetta Leo;Simone A. Baechler

  • Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

    Anthony Tubbs;Sriram Sridharan;Niek van Wietmarschen;Yaakov Maman

  • Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes

    Marie Regairaz;Yong-Wei Zhang;Haiqing Fu;Keli K. Agama

  • Molecular interaction maps of bioregulatory networks: a general rubric for systems biology.

    Kurt W. Kohn;Mirit I. Aladjem;John N. Weinstein;Yves Pommier

  • Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.

    Chiara Conti;Elisabetta Leo;Gabriel S. Eichler;Olivier Sordet

  • Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.

    Anish Thomas;Christophe E. Redon;Linda Sciuto;Emerson Padiernos

  • CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics.

    Augustin Luna;Fathi Elloumi;Sudhir Varma;Yanghsin Wang

  • Genome-wide depletion of replication initiation events in highly transcribed regions

    Melvenia M. Martin;Michael Ryan;Ryang Guk Kim;Anna L. Zakas

  • Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

    Anish Thomas;Nobuyuki Takahashi;Vinodh N. Rajapakse;Xiaohu Zhang

  • CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines.

    Vinodh N. Rajapakse;Augustin Luna;Mihoko Yamade;Lisa Loman

  • ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin

    Kyoo-young Lee;Haiqing Fu;Mirit I. Aladjem;Kyungjae Myung

  • SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.

    Camille Tlemsani;Lorinc Pongor;Fathi Elloumi;Luc Girard

Frequent Co-Authors

Yves Pommier
Yves Pommier National Institutes of Health
Christophe E. Redon
Christophe E. Redon National Institutes of Health
Kurt W. Kohn
Kurt W. Kohn National Institutes of Health
William C. Reinhold
William C. Reinhold National Institutes of Health
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Chris Sander
Chris Sander Harvard University
Eric E. Bouhassira
Eric E. Bouhassira Albert Einstein College of Medicine
John N. Weinstein
John N. Weinstein The University of Texas MD Anderson Cancer Center
Geoffrey M. Wahl
Geoffrey M. Wahl Salk Institute for Biological Studies
Kannanganattu V. Prasanth
Kannanganattu V. Prasanth University of Illinois at Urbana-Champaign

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