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Immunology

D-Index
108
Citations
40368
World Ranking
533
National Ranking
323

Medicine

D-Index
108
Citations
40392
World Ranking
6036
National Ranking
3227

Research.com Recognitions

  • 2016 - Member of the National Academy of Sciences

Overview

Kenneth M. Murphy is affiliated with Washington University in St. Louis in the United States. Their research centers on immunology and microbiology, with significant contributions also made in medicine. The primary subfields of study include immunology, oncology, molecular biology, infectious diseases, and genetics.

The scientist's work focuses notably on topics such as immunotherapy and immune responses, T-cell and B-cell immunology, immune cell function and interaction, cancer immunotherapy and biomarkers, immune cells in cancer, RNA interference and gene delivery, and CAR-T cell therapy research.

Frequent publication venues for their research include The Journal of Immunology, Immunity, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Experimental Medicine, and Proceedings of the National Academy of Sciences.

Kenneth M. Murphy has collaborated regularly with several researchers, including Tiantian Liu, Sun Kyung Kim, Theresa L. Murphy, Feiya Ou, and Renee Wu.

Some recent papers authored or co-authored by Murphy are listed below:

  • "cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity," 2020, Nature
  • "Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer," 2020, Cancer Cell
  • "Genetic models of human and mouse dendritic cell development and function," 2020, Nature Reviews Immunology
  • "Dendritic cells in cancer immunology," 2021, Cellular and Molecular Immunology
  • "Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer," 2022, Immunity

Kenneth M. Murphy was elected as a Member of the National Academy of Sciences in 2016.

Best Publications

  • Dendritic cell regulation of TH1-TH2 development.

    Muriel Moser;Kenneth M. Murphy

  • Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells.

    Susanne J. Szabo;Anand S. Dighe;Ueli Gubler;Kenneth M. Murphy

  • Type I interferon is selectively required by dendritic cells for immune rejection of tumors

    Mark S. Diamond;Michelle Kinder;Hirokazu Matsushita;Mona Mashayekhi

  • Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells

    Brian T. Edelson;Wumesh Kc;Richard Juang;Masako Kohyama

  • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

    N. G. Jacobson;S. J. Szabo;R. M. Weber-Nordt;Zhong Zhong

  • Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

    Shruti Naik;Nicolas Bouladoux;Jonathan L. Linehan;Seong-Ji Han

  • Signaling and Transcription in T Helper Development

    Kenneth M. Murphy;Wenjun Ouyang;J. David Farrar;Jianfei Yang

  • B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.

    John R Sedy;Maya Gavrieli;Karen G Potter;Michelle A Hurchla

  • Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.

    Ehud Zigmond;Chen Varol;Julia Farache;Elinor Elmaliah

  • Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.

    T L Murphy;M G Cleveland;P Kulesza;J Magram

  • Activation of human CD4 + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

    Claudia Kemper;Andrew C Chan;Jonathan M Green;Kelly A Brett

  • Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

    Ansuman T. Satpathy;Wumesh Kc;Jörn C. Albring;Brian T. Edelson

  • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

    Peter Openshaw;Erin E. Murphy;Nancy A. Hosken;Vernon Maino

  • T CELL GENETIC BACKGROUND DETERMINES DEFAULT T HELPER PHENOTYPE DEVELOPMENT IN VITRO

    Chyi-Song Hsieh;Steven E. Macatonia;Anne O'Garra;Kenneth M. Murphy

  • Effector T cell plasticity: flexibility in the face of changing circumstances

    Kenneth M Murphy;Brigitta Stockinger

  • B7x: A widely expressed B7 family member that inhibits T cell activation

    Xingxing Zang;P'ng Loke;Jayon Kim;Kenneth Murphy

  • Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

    E Murphy;K Shibuya;N Hosken;P Openshaw

  • Role of cytokines in determining T-lymphocyte function

    Anne O'Garra;Kenneth Murphy

  • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

    Susanne J. Szabo;Nile G. Jacobson;Anand S. Dighe;Uell Gubler

  • BATF–JUN is critical for IRF4-mediated transcription in T cells

    Peng Li;Rosanne Spolski;Wei Liao;Lu Wang

  • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes

    Yoichi Shinkai;Shigeo Koyasu;Kei Ichi Nakayama;Kenneth M. Murphy

Frequent Co-Authors

Theresa L. Murphy
Theresa L. Murphy Washington University in St. Louis
Ansuman T. Satpathy
Ansuman T. Satpathy Stanford University
Wenjun Ouyang
Wenjun Ouyang Amgen (United States)
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Carl F. Ware
Carl F. Ware Sanford Burnham Prebys Medical Discovery Institute
Chyi-Song Hsieh
Chyi-Song Hsieh Washington University in St. Louis
Klaus Pfeffer
Klaus Pfeffer Heinrich Heine University Düsseldorf
Robert D. Schreiber
Robert D. Schreiber Washington University in St. Louis
Marco Colonna
Marco Colonna Washington University in St. Louis
L. David Sibley
L. David Sibley Washington University in St. Louis

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