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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
166
Citations
112141
World Ranking
61
National Ranking
43

Medicine

D-Index
166
Citations
112141
World Ranking
606
National Ranking
351

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award

Overview

Giorgio Trinchieri is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology, immunology, oncology, epidemiology, and infectious diseases as subfields.

The main topics of their work include:

  • Gut microbiota and health
  • Cancer immunotherapy and biomarkers
  • Immune cell function and interaction
  • Clostridium difficile and Clostridium perfringens research
  • Immunotherapy and immune responses
  • Pancreatic and hepatic oncology research
  • Tryptophan and brain disorders

Recent notable publications by Trinchieri include:

  • "Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients" (2021, Science)
  • "Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response" (2021, Science)
  • "Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1" (2022, Nature Medicine)
  • "Targeting the gut microbiota for cancer therapy" (2022, Nature Reviews Cancer)
  • "Infection trains the host for microbiota-enhanced resistance to pathogens" (2021, Cell)

The frequent coauthors collaborating with Trinchieri include:

  • John A. McCulloch
  • Amiran Dzutsev
  • Richard R. Rodrigues
  • Jonathan H. Badger
  • Hassane M. Zarour

Publication venues where Trinchieri contributes regularly encompass a variety of high-impact journals, such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Journal of Immunology
  • Cancer Discovery

Their body of work integrates detailed molecular and immunological analysis with cancer research, focusing extensively on the interplay between the gut microbiota and cancer immunotherapy outcomes. The research typically addresses how microbial environments influence immune cell functions and therapeutic responses in oncology contexts.

Best Publications

  • Interleukin-12 and the regulation of innate resistance and adaptive immunity

    Giorgio Trinchieri

  • Biology of natural killer cells.

    Giorgio Trinchieri

  • Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

    Giorgio Trinchieri

  • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

    M Kobayashi;L Fitz;M Ryan;R M Hewick

  • Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

    Noriho Iida;Amiran Dzutsev;C. Andrew Stewart;Loretta Smith

  • Plasmacytoid dendritic cells in immunity.

    Marco Colonna;Giorgio Trinchieri;Yong Jun Liu

  • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

    R Manetti;P Parronchi;M G Giudizi;M P Piccinni

  • Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

    S. E. Macatonia;N. A. Hosken;M. Litton;P. Vieira

  • Cooperation of Toll-like receptor signals in innate immune defence.

    Giorgio Trinchieri;Alan Sher

  • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

    A. D'andrea;M. Aste-Amezaga;N. M. Valiante;Xiaojing Ma

  • Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

    Diwakar Davar;Amiran K. Dzutsev;John A. McCulloch;Richard R. Rodrigues

  • Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

    Chi Ma;Miaojun Han;Bernd Heinrich;Qiong Fu

  • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.

    Sergei I. Grivennikov;Kepeng Wang;Daniel Mucida;C. Andrew Stewart

  • Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes.

    G Trinchieri

  • Reciprocal activating interaction between natural killer cells and dendritic cells.

    Franca Gerosa;Barbara Baldani-Guerra;Carla Nisii;Viviana Marchesini

  • Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology.

    Carine Asselin-Paturel;Andre Boonstra;Marc Dalod;Isabelle Durand

  • The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses

    Giorgio Trinchieri;Stefan Pflanz;Robert A Kastelein

  • Compartmentalized Control of Skin Immunity by Resident Commensals

    Shruti Naik;Nicolas Bouladoux;Christoph Wilhelm;Michael J. Molloy

  • Interleukin-12 and its role in the generation of TH1 cells

    Giorgio Trinchieri

  • Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

    S H Chan;B Perussia;J W Gupta;M Kobayashi

  • Type I interferon: friend or foe?

    Giorgio Trinchieri

Frequent Co-Authors

Maria Wysocka
Maria Wysocka University of Pennsylvania
Xiaojing Ma
Xiaojing Ma Shanghai Jiao Tong University
Bice Perussia
Bice Perussia Kimmel Cancer Center
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Christophe Caux
Christophe Caux Cancer Center of Lyon
Marco A. Cassatella
Marco A. Cassatella University of Verona
Phillip Scott
Phillip Scott University of Pennsylvania
Nicholas M. Valiante
Nicholas M. Valiante Novartis (Switzerland)
Francine Brière
Francine Brière Baylor Scott & White Health
Christopher L. Karp
Christopher L. Karp Bill & Melinda Gates Foundation

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