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Nicholas M. Valiante

Nicholas M. Valiante

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
16574
World Ranking
18820
National Ranking
362

Overview

Nicholas M. Valiante is affiliated with Novartis in Switzerland, contributing to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, computational theory and mathematics, materials chemistry, and epidemiology.

The scientist's main topics of work include:

  • Computational Drug Discovery Methods
  • Machine Learning in Materials Science
  • Chemical Synthesis and Analysis
  • Bacillus and Francisella bacterial research
  • Influenza Virus Research Studies
  • Hepatitis B Virus Studies
  • Protein Structure and Dynamics

Frequent collaboration is observed with several coauthors, including:

  • Paul A. Bertin
  • Jarrid Rector-Brooks
  • Deepak Sharma
  • Thomas Gaudelet
  • Andrew Anighoro

Valiante has published in venues such as:

  • Regular and Young Investigator Award Abstracts
  • Cell Reports Methods
  • Frontiers in Microbiology
  • arXiv (Cornell University)

Recent papers authored or coauthored by Valiante include:

  • RECOVER identifies synergistic drug combinations in vitro through sequential model optimization, 2023, Cell Reports Methods
  • RECOVER: sequential model optimization platform for combination drug repurposing identifies novel synergistic compounds in vitro, 2022, arXiv (Cornell University)
  • A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis, 2022, Frontiers in Microbiology
  • 822 Computational modeling to overcome MHC diversity and drive potent and diverse neoantigen and viral antigen specific killer T cell responses, 2025, Regular and Young Investigator Award Abstracts
  • 562 A phase Ia study to assess the safety, tolerability and immunogenicity of a personalized cancer vaccine (InnoPCV/INV002) in patients with advanced solid tumors, 2025, Regular and Young Investigator Award Abstracts

Best Publications

  • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

    A. D'andrea;M. Aste-Amezaga;N. M. Valiante;Xiaojing Ma

  • Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

    A D'Andrea;M Rengaraju;N M Valiante;J Chehimi

  • Human Diversity in Killer Cell Inhibitory Receptor Genes

    Markus Uhrberg;Nicholas M Valiante;Benny P Shum;Heather G Shilling

  • Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

    Nicholas M Valiante;Markus Uhrberg;Heather G Shilling;Kristin Lienert-Weidenbach

  • Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells.

    Diego Piccioli;Silverio Sbrana;Emiliano Melandri;Nicholas M. Valiante

  • mTOR inhibition improves immune function in the elderly

    Joan B. Mannick;Giuseppe Del Giudice;Maria Lattanzi;Nicholas M. Valiante

  • Targeting the innate immune response with improved vaccine adjuvants

    Achal Pashine;Nicholas M Valiante;Jeffrey B Ulmer

  • Nonviral delivery of self-amplifying RNA vaccines

    Andrew J. Geall;Ayush Verma;Gillis R. Otten;Christine A. Shaw

  • Interleukin 10 (IL-10) Inhibits Human Lymphocyte Interferon 3,-Production by Suppressing Natural Killer Cell Stimulatory Factor/IL-12 Synthesis in Accessory Cells By Annalisa D'Andrea, Miguel Aste-Amezaga,

    Nicholas M. Valiante;Xiaojing Ma;Marek Kubin;Giorgio Trinchieri

  • Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

    Stefania Crotta;Annalisa Stilla;Andreas Wack;Annalisa D'Andrea

  • Recent advances in the discovery and delivery of vaccine adjuvants.

    Derek T. O'Hagan;Nicholas M. Valiante

  • New adjuvants for human vaccines.

    M Lamine Mbow;Ennio De Gregorio;Nicholas M Valiante;Rino Rappuoli

  • A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

    Luis A Brito;Michelle Chan;Christine A Shaw;Armin Hekele

  • Rapid Evolution of NK Cell Receptor Systems Demonstrated by Comparison of Chimpanzees and Humans

    Salim I Khakoo;Raja Rajalingam;Benny P Shum;Kristin Weidenbach

  • Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

    Nicholas M. Valiante;Giorgio Trinchieri

  • NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection

    Monia Draghi;Achal Pashine;Bharati Sanjanwala;Ketevan Gendzekhadze

  • Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation.

    Giorgio Trinchieri;Maria Wysocka;Annalisa D'Andrea;Manthrasalam Rengaraju

  • Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor.

    J E Gumperz;L D Barber;N M Valiante;L Percival

  • Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype.

    J E Gumperz;N M Valiante;P Parham;L L Lanier

  • Dynamics of intra‐hepatic lymphocytes in chronic hepatitis C: enrichment for Vα24+ T cells and rapid elimination of effector cells by apoptosis

    Sandra Nuti;Domenico Rosa;Nicholas M. Valiante;Giulietta Saletti

Frequent Co-Authors

Peter Parham
Peter Parham Stanford University
Manmohan Singh
Manmohan Singh Beam Therapeutics
Derek O'hagan
Derek O'hagan GlaxoSmithKline (United Kingdom)
Lewis L. Lanier
Lewis L. Lanier University of California, San Francisco
Ennio De Gregorio
Ennio De Gregorio Novartis (Switzerland)
Giorgio Trinchieri
Giorgio Trinchieri National Institutes of Health
Rino Rappuoli
Rino Rappuoli Imperial College London
Jeffrey B. Ulmer
Jeffrey B. Ulmer Novartis (Switzerland)
John J. Donnelly
John J. Donnelly Novartis (United States)
Andreas Wack
Andreas Wack The Francis Crick Institute

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