World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
101
Citations
35478
World Ranking
1451
National Ranking
825

Overview

Eric O. Long is affiliated with the National Institutes of Health in the United States. Their research contributions primarily span the fields of immunology and microbiology, with a focus on immunology, oncology, and public health-related disciplines. Their work covers several specialized subfields including immunology, oncology, epidemiology, and molecular biology.

The scientist's research topics emphasize cellular immune responses and therapies. Specific areas of focus include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T Cell Therapy Research
  • Malaria Research and Control
  • Complement System in Diseases
  • Reproductive System and Pregnancy

Their recent papers illustrate a concentration on immune mechanisms and therapeutic targeting, with notable publications such as:

  • "High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D," 2020, Proceedings of the National Academy of Sciences
  • "Plasmodium falciparum -specific IgM B cells dominate in children, expand with malaria, and produce functional IgM," 2021, The Journal of Experimental Medicine
  • "Innate receptors with high specificity for HLA class I-peptide complexes," 2023, Science Immunology
  • "PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity," 2020, Infection and Immunity
  • "Dendritic cells Trigger IFN-γ secretion by NK cells independent of IL-12 and IL-18," 2022, European Journal of Immunology

Frequent coauthors include Malcolm J. W. Sim, Jinghua Lu, Peter D. Sun, Padmapriya Sekar, and Peter D. Crompton, indicating collaborative work across immunology and related biomedical research fields.

Eric O. Long has published multiple articles in respected venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • European Journal of Immunology
  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine

The scientific output reflects a sustained engagement with topics central to immune cell function, molecular immunology, infectious disease response, and targeted immunotherapies. This body of work contributes to understanding complex immune mechanisms and the development of therapeutic approaches in oncology and infectious diseases.

Best Publications

  • Repeated genes in eukaryotes.

    Eric O. Long;Igor B. Dawid

  • Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

    Eric O. Long;Hun Sik Kim;Dongfang Liu;Mary E. Peterson

  • Regulation of immune responses through inhibitory receptors.

    Eric O. Long

  • Regulation of human NK-cell cytokine and chemokine production by target cell recognition

    Cyril Fauriat;Eric O. Long;Hans-Gustaf Ljunggren;Yenan T. Bryceson

  • Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion.

    Yenan T. Bryceson;Michael E. March;Michael E. March;Hans-Gustaf Ljunggren;Hans-Gustaf Ljunggren;Eric O. Long;Eric O. Long

  • A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells

    Sumati Rajagopalan;Eric O. Long

  • Activation, coactivation, and costimulation of resting human natural killer cells

    Yenan T. Bryceson;Michael E. March;Hans-Gustaf Ljunggren;Eric O. Long

  • Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

    Deborah N Burshtyn;Andrew M Scharenberg;Nicolai Wagtmann;Sumati Rajagopalan

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

    Nicolai Wagtmann;Roberto Biassoni;Claudia Cantoni;Simonetta Verdiani

  • Essential Role of LAT in T Cell Development

    Weiguo Zhang;Connie L Sommers;Deborah N Burshtyn;Christopher C Stebbins

  • Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells

    Yenan T. Bryceson;Michael E. March;Domingo F. Barber;Hans-Gustaf Ljunggren

  • A molecular map of the immune response region from the major histocompatibility complex of the mouse

    Michael Steinmetz;Karyl Minard;Suzanna Horvath;Janet McNicholas

  • Direct Binding and Functional Transfer of NK Cell Inhibitory Receptors Reveal Novel Patterns of HLA-C Allotype Recognition

    Christine C. Winter;Jenny E. Gumperz;Peter Parham;Eric O. Long

  • Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

    Paul Maddon;Rafick Sekaly;Mary Anne Talle

  • Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

    Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman

  • Negative signaling by inhibitory receptors: the NK cell paradigm

    Eric O. Long

  • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

    Roland Martin;Dolores Jaraquemada;Marjorie Flerlage;John Richert

  • Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

    Nicolai Wagtmann;Sumati Rajagopalan;Christine C. Winter;Marta Peruui

  • Activation of NK cells by an endocytosed receptor for soluble HLA-G.

    Sumati Rajagopalan;Yenan T Bryceson;Shanmuga P Kuppusamy;Daniel E Geraghty

  • DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

    C Tonnelle;R DeMars;E O Long

Frequent Co-Authors

Bernard Mach
Bernard Mach University of Geneva
Yenan T. Bryceson
Yenan T. Bryceson Karolinska Institute
Carsten Watzl
Carsten Watzl TU Dortmund University
Mauro S. Malnati
Mauro S. Malnati Vita-Salute San Raffaele University
Henry F. McFarland
Henry F. McFarland National Institutes of Health
Peter D. Crompton
Peter D. Crompton National Institute of Allergy and Infectious Diseases
Hans-Gustaf Ljunggren
Hans-Gustaf Ljunggren Karolinska Institute
Roland Martin
Roland Martin University of Zurich
Igor B. Dawid
Igor B. Dawid National Institutes of Health
Don C. Wiley
Don C. Wiley Harvard University

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