World's Best Scientists 2026 revealed!
Alexander Dobrovic

Alexander Dobrovic

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
18816
World Ranking
5944
National Ranking
142

Medicine

D-Index
73
Citations
18834
World Ranking
19663
National Ranking
666

Overview

Alexander Dobrovic is affiliated with the University of Melbourne in Australia. Their research primarily focuses on medicine and biochemistry, genetics and molecular biology, with significant contributions spanning molecular biology, oncology, cancer research, surgery, and transplantation.

Their recent publications include:

  • Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2), 2021, Nature Communications
  • Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma, 2021, Cancer Research
  • Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain, 2021, Brain Communications
  • Removing unwanted variation from large-scale RNA sequencing data with PRPS, 2022, Nature Biotechnology
  • The role of aberrant DNA methylation in cancer initiation and clinical impacts, 2024, Therapeutic Advances in Medical Oncology

The scientist's main topics of work cover:

  • PARP inhibition in cancer therapy
  • Cancer Genomics and Diagnostics
  • Renal Transplantation Outcomes and Treatments
  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Organ Transplantation Techniques and Outcomes

Frequent co-authors collaborating with Alexander Dobrovic include:

  • Vijayaragavan Muralidharan
  • Clare L. Scott
  • Adam Testro
  • Olga Kondrashova
  • Daniel Cox

Their work is regularly published in key venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Chemistry
  • Therapeutic Advances in Medical Oncology
  • World Journal of Transplantation
  • HPB

Best Publications

  • BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

    Kathryn Alsop;Sian Fereday;Cliff Meldrum;Anna deFazio

  • Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

    Tomasz K. Wojdacz;Alexander Dobrovic

  • Methylation of the BRCA1 gene in sporadic breast cancer

    Alexander Dobrovic;David Simpfendorfer

  • Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

    Hongdo Do;Hongdo Do;Hongdo Do;Alexander Dobrovic;Alexander Dobrovic;Alexander Dobrovic

  • A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.

    James Dan Mellor;James Dan Mellor;Michael Brown;Helen Ruth Irving;John Raymond Zalcberg;John Raymond Zalcberg

  • High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.

    Michael Krypuy;Genni M Newnham;Genni M Newnham;David M Thomas;David M Thomas;Matthew Conron

  • Methylation-sensitive high-resolution melting

    Tomasz K Wojdacz;Tomasz K Wojdacz;Alexander Dobrovic;Lise Lotte Hansen

  • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

    Maya Kansara;Michael Tsang;Laurent Kodjabachian;Natalie A. Sims

  • Empirical array quality weights in the analysis of microarray data

    Matthew E. Ritchie;Dileepa S. Diyagama;Jody Neilson;Ryan van Laar

  • GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly.

    Daniel L. Cameron;Jan Schröder;Jan Schröder;Jocelyn Sietsma Penington;Hongdo Do

  • Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma

    Bianca Devitt;Wendy Liu;Renato Salemi;Rory Wolfe

  • High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

    Hongdo Do;Hongdo Do;Michael Krypuy;Paul L Mitchell;Stephen B Fox;Stephen B Fox

  • Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing.

    Stephen Q Wong;Jason Li;Angela Y-C Tan;Ravikiran Vedururu

  • Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.

    Richard J. Young;Kelly Waldeck;Claire Martin;Jung H. Foo

  • Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.

    Olga Kondrashova;Olga Kondrashova;Monique Topp;Monique Topp;Ksenija Nesic;Ksenija Nesic;Elizabeth Lieschke

  • Distinct Clinical and Pathological Features Are Associated with the BRAFT1799A(V600E) Mutation in Primary Melanoma

    Wendy Liu;John W Kelly;Melanie Trivett;William K Murray

  • Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection.

    Lasse S. Kristensen;Thomas Mikeska;Michael Krypuy;Alexander Dobrovic

  • Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer

    M.B. Loughrey;Paul Waring;Paul Waring;A. Tan;M. Trivett

  • Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

    Jennifer E. Hardingham;Peter J. Hewett;Robert E. Sage;Jennie L. Finch

  • Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies.

    Hongdo Do;Hongdo Do;Alexander Dobrovic;Alexander Dobrovic

Frequent Co-Authors

Stephen B. Fox
Stephen B. Fox Peter MacCallum Cancer Centre
Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Erik W. Thompson
Erik W. Thompson Queensland University of Technology
David D.L. Bowtell
David D.L. Bowtell Peter MacCallum Cancer Centre
Paul Mitchell
Paul Mitchell University of Sydney
Jonathan Cebon
Jonathan Cebon La Trobe University
Clare L. Scott
Clare L. Scott Walter and Eliza Hall Institute of Medical Research
Ian G. Campbell
Ian G. Campbell Peter MacCallum Cancer Centre
Anthony T. Papenfuss
Anthony T. Papenfuss Walter and Eliza Hall Institute of Medical Research
Benjamin Solomon
Benjamin Solomon Peter MacCallum Cancer Centre

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