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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
24607
World Ranking
8466
National Ranking
211

Research.com Recognitions

  • 2017 - Fellow of the Australian Academy of Health and Medical Science

Overview

Clare L. Scott is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on subfields including Oncology, Molecular Biology, Reproductive Medicine, Genetics, and Cancer Research.

The scientist's work addresses several main topics, such as ovarian cancer diagnosis and treatment, PARP inhibition in cancer therapy, DNA repair mechanisms, BRCA gene mutations in cancer, CRISPR and genetic engineering, cancer genomics and diagnostics, and treatments for endometrial and cervical cancer.

Among recent publications, notable papers include:

  • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution (2021), published in Kent Academic Repository (University of Kent)
  • ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer (2020), published in Annals of Oncology
  • Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial (2021), published in The Lancet Oncology
  • CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer (2020), published in Nature Communications
  • Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2) (2021), published in Nature Communications

Frequent co-authors throughout the scientist's career include Jonathan A. Ledermann, Matthew J. Wakefield, Chunxue Bai, Joseph Bauer, and Eric Bernicker.

Publications have appeared predominantly in venues such as Cancer, Journal of Clinical Oncology, bioRxiv (Cold Spring Harbor Laboratory), Clinical Cancer Research, and Cancer Research.

In recognition of their contributions, Clare L. Scott was named a Fellow of the Australian Academy of Health and Medical Science in 2017.

Best Publications

  • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer.

    Jonathan Ledermann;Philipp Harter;Charlie Gourley;Michael Friedlander

  • Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial

    Eric Pujade-Lauraine;Jonathan A Ledermann;Frédéric Selle;Val Gebski

  • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial

    Jonathan Ledermann;Philipp Harter;Charlie Gourley;Michael Friedlander

  • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

    Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg

  • Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

    David D. Bowtell;David D. Bowtell;Steffen Böhm;Ahmed A. Ahmed;Paul Joseph Aspuria

  • Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

    Elizabeth M Swisher;Kevin K Lin;Amit M Oza;Clare L Scott

  • SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

    Warren S Alexander;Robyn Starr;Robyn Starr;Jennifer E Fenner;Clare L Scott;Clare L Scott

  • Dominant Negative ATM Mutations in Breast Cancer Families

    Georgia Chenevix-Trench;Amanda B. Spurdle;Magtouf Gatei;Helena Kelly

  • Poly (ADP-Ribose) Polymerase Inhibitors: Recent Advances and Future Development

    Clare L. Scott;Elizabeth M. Swisher;Scott H. Kaufmann

  • Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

    Olga Kondrashova;Olga Kondrashova;Minh Nguyen;Kristy Shield-Artin;Kristy Shield-Artin;Anna V Tinker

  • ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.

    R.E. Miller;R.E. Miller;A. Leary;C.L. Scott;C.L. Scott;V. Serra

  • BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

    Kevin K. Lin;Maria I. Harrell;Amit M. Oza;Ana Oaknin

  • p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

    Liz J. Valente;Daniel H.D. Gray;Daniel H.D. Gray;Ewa M. Michalak;Ewa M. Michalak;Josefina Pinon-Hofbauer

  • DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

    Jeffrey B. Kerr;Karla J. Hutt;Karla J. Hutt;Ewa M. Michalak;Ewa M. Michalak;Michele Cook

  • Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

    Ralph K Lindemann;Andrea Newbold;K F Whitecross;Leonie A Cluse

  • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

    Mark S. Cragg;Claire Harris;Claire Harris;Andreas Strasser;Clare L. Scott;Clare L. Scott

  • Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

    Mark S. Cragg;Elisa S. Jansen;Michele Cook;Claire Harris

  • Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.

    Olga Kondrashova;Olga Kondrashova;Monique Topp;Monique Topp;Ksenija Nesic;Ksenija Nesic;Elizabeth Lieschke

  • Role of the chromobox protein CBX7 in lymphomagenesis

    Clare L. Scott;Jésus Gil;Eva Hernando;Julie Teruya-Feldstein

  • Genetic Influences Determining Progenitor Cell Mobilization and Leukocytosis Induced by Granulocyte Colony-Stimulating Factor

    Andrew W. Roberts;Simon Foote;Warren S. Alexander;Clare Scott

Frequent Co-Authors

David D.L. Bowtell
David D.L. Bowtell Peter MacCallum Cancer Centre
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Elizabeth M. Swisher
Elizabeth M. Swisher University of Washington
Michael Friedlander
Michael Friedlander University of New South Wales
Jonathan A. Ledermann
Jonathan A. Ledermann University College London
Amit M. Oza
Amit M. Oza Princess Margaret Cancer Centre
Ursula A. Matulonis
Ursula A. Matulonis Harvard University
Robert L. Coleman
Robert L. Coleman The University of Texas MD Anderson Cancer Center
Stephen B. Fox
Stephen B. Fox Peter MacCallum Cancer Centre

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