2023 - Research.com Biology and Biochemistry in Australia Leader Award
Cell biology, Programmed cell death, Apoptosis, Cancer research and Pharmacology are his primary areas of study. The concepts of his Cell biology study are interwoven with issues in Caspase, Peptide sequence, Bcl-2 family and Bcl-2-associated X protein. His Programmed cell death research includes elements of Cell culture, Signal transduction and Immunology.
His study explores the link between Apoptosis and topics such as Molecular biology that cross with problems in Cell type. His research in Cancer research focuses on subjects like Cell killing, which are connected to Progenitor cell and Large-cell lymphoma. His Pharmacology research also works with subjects such as
David C.S. Huang mainly focuses on Apoptosis, Cell biology, Cancer research, Programmed cell death and Venetoclax. His work in Apoptosis addresses issues such as Cell culture, which are connected to fields such as Multiple myeloma. He interconnects Caspase, Bcl-2 Homologous Antagonist-Killer Protein, Bcl-2 family and Bcl-2-associated X protein in the investigation of issues within Cell biology.
The concepts of his Cancer research study are interwoven with issues in Hematology, Internal medicine, Leukemia, Immunology and MCL1. His Leukemia study combines topics in areas such as Myeloid, Cancer, Navitoclax and Pharmacology. David C.S. Huang combines subjects such as Molecular biology, Cell cycle, Mitochondrion and Puma with his study of Programmed cell death.
David C.S. Huang mostly deals with Cancer research, Venetoclax, Internal medicine, Hematology and Leukemia. His Cancer research research integrates issues from Cell culture, Apoptosis, Transcription factor, B cell and Multiple myeloma. David C.S. Huang works in the field of Apoptosis, focusing on Caspase in particular.
His Venetoclax study integrates concerns from other disciplines, such as Mutation, Myeloid leukemia, MCL1 and Lymphoma. His Internal medicine study combines topics from a wide range of disciplines, such as Neoplasm and Oncology. His work carried out in the field of Intrinsic apoptosis brings together such families of science as Cell, Bcl-2 Homologous Antagonist-Killer Protein and Cell biology.
David C.S. Huang focuses on Venetoclax, Cancer research, Internal medicine, Leukemia and Hematology. In his research, David C.S. Huang undertakes multidisciplinary study on Cancer research and Neonatal Fc receptor. His studies in Leukemia integrate themes in fields like Oncology, Myeloid, B cell, Myeloid leukemia and Drug resistance.
His B cell research incorporates elements of Chronic lymphocytic leukemia and Rituximab. His research in Myeloid leukemia tackles topics such as Myeloid Cell Leukemia Sequence 1 Protein which are related to areas like MCL1. He has included themes like Apoptosis, Plasma protein binding, Mutant and Binding site in his Mutation study.
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Andrew J Souers;Joel D Leverson;Erwin R Boghaert;Scott L Ackler.
Nature Medicine (2013)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Lin Chen;Simon N. Willis;Andrew Wei;Brian J. Smith.
Molecular Cell (2005)
The Bcl-2 family: roles in cell survival and oncogenesis.
Suzanne Cory;David C S Huang;Jerry M Adams.
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Philippe Bouillet;Donald Metcalf;David C. S. Huang;David M. Tarlinton.
Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins
Simon N. Willis;Lin Chen;Grant Dewson;Andrew Wei.
Genes & Development (2005)
The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex
Hamsa Puthalakath;David C.S Huang;Lorraine A O’Reilly;Stephen M King.
Molecular Cell (1999)
Bim: a novel member of the Bcl-2 family that promotes apoptosis
Liam O'Connor;Andreas Strasser;Lorraine A. O'Reilly;George Hausmann.
The EMBO Journal (1998)
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft.
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg.
Cancer Cell (2006)
BH3-Only proteins-essential initiators of apoptotic cell death.
David C.S Huang;Andreas Strasser.
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