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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
108
Citations
55320
World Ranking
1033
National Ranking
27

Medicine

D-Index
108
Citations
54995
World Ranking
5913
National Ranking
166

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

David C. S. Huang is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. The research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions in subfields such as Molecular Biology, Genetics, Hematology, Oncology, and Immunology.

The scientist's work focuses on several specialized topics including:

  • Chronic Lymphocytic Leukemia Research
  • Cell death mechanisms and regulation
  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Phagocytosis and Immune Regulation

Recent publications illustrate ongoing contributions to blood cancers and cellular processes, with notable papers such as:

  • "Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML" (2020), published in Blood
  • "Mesenchymal stromal cell apoptosis is required for their therapeutic function" (2021), published in Nature Communications
  • "Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing" (2021), published in Genome Biology
  • "BCL2 and MCL1 inhibitors for hematologic malignancies" (2021), published in Blood
  • "Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax" (2020), published in Blood

The scientist frequently publishes in journals and platforms such as Blood, bioRxiv (Cold Spring Harbor Laboratory), Cell Death and Differentiation, Blood Advances, and Cancer Research.

Collaborative efforts are evident with frequent co-authors including Andrew W. Roberts, Rachel Thijssen, Andrew H. Wei, Mary Ann Anderson, and Guillaume Lessène, reflecting sustained partnerships in research projects.

Best Publications

  • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

    Andrew J Souers;Joel D Leverson;Erwin R Boghaert;Scott L Ackler

  • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

    Lin Chen;Simon N. Willis;Andrew Wei;Brian J. Smith

  • The Bcl-2 family: roles in cell survival and oncogenesis.

    Suzanne Cory;David C S Huang;Jerry M Adams

  • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.

    Philippe Bouillet;Donald Metcalf;David C. S. Huang;David M. Tarlinton

  • Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but Not Bcl-2, Until Displaced by BH3-only Proteins

    Simon N. Willis;Lin Chen;Grant Dewson;Andrew Wei

  • Bim: a novel member of the Bcl-2 family that promotes apoptosis

    Liam O'Connor;Andreas Strasser;Lorraine A. O'Reilly;George Hausmann

  • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

    Mark F. van Delft;Andrew H. Wei;Kylie D. Mason;Kylie D. Mason;Cassandra J. Vandenberg

  • The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

    Hamsa Puthalakath;David C.S Huang;Lorraine A O’Reilly;Stephen M King

  • Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

    Simon N. Willis;Jamie I. Fletcher;Thomas Kaufmann;Mark F. van Delft;Mark F. van Delft

  • BH3-Only proteins-essential initiators of apoptotic cell death.

    David C.S Huang;Andreas Strasser

  • Programmed Anuclear Cell Death Delimits Platelet Life Span

    Kylie D Mason;Marina Carpinelli;Jamie I Fletcher;Janelle Elyse Collinge

  • The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

    András Kotschy;Zoltán Szlavik;James Murray;James Davidson

  • Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

    Michael J. White;Michael J. White;Kate McArthur;Kate McArthur;Donald Metcalf;Donald Metcalf;Rachael M. Lane

  • Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

    Andrew W. Roberts;John F. Seymour;John F. Seymour;Jennifer R. Brown;William G. Wierda

  • Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

    Andreas Strasser;Alan W. Harris;David C S Huang;Peter H. Krammer

  • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

    Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  • Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.

    Hamsa Puthalakath;Andreas Villunger;Lorraine A. O'Reilly;Jennifer G. Beaumont

  • Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

    Martin Schwickart;XiaoDong Huang;Jennie R. Lill;Jinfeng Liu

  • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

    Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  • Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.

    Peter E. Czabotar;Peter E. Czabotar;Dana Westphal;Dana Westphal;Grant Dewson;Grant Dewson;Stephen Ma;Stephen Ma

Frequent Co-Authors

Andrew W. Roberts
Andrew W. Roberts Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
David J. Segal
David J. Segal University of California, Davis
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
John F. Seymour
John F. Seymour Peter MacCallum Cancer Centre
Andrew Wei
Andrew Wei Walter and Eliza Hall Institute of Medical Research
Lorraine A. O'Reilly
Lorraine A. O'Reilly Walter and Eliza Hall Institute of Medical Research
Jerry M. Adams
Jerry M. Adams Walter and Eliza Hall Institute of Medical Research

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