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Alessandro Moretta

Alessandro Moretta

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Immunology
Italy
2023
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Medicine
Italy
2023

D-Index & Metrics

Immunology

D-Index
152
Citations
77915
World Ranking
114
National Ranking
4

Medicine

D-Index
152
Citations
77937
World Ranking
1086
National Ranking
25

Research.com Recognitions

  • 2023 - Research.com Immunology in Italy Leader Award
  • 2023 - Research.com Medicine in Italy Leader Award
  • 2022 - Research.com Immunology in Italy Leader Award

Overview

Alessandro Moretta was affiliated with the University of Genoa in Italy and contributed to the fields of Immunology and Microbiology as well as Medicine. Their research primarily revolved around Immunology, with additional focus on Hematology and Oncology subfields.

The scientist's main topics of work included:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Hematopoietic Stem Cell Transplantation
  • CAR-T cell therapy research

Moretta's recent publications covered various aspects of immune cell biology and therapeutic interventions. These included:

  • "Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia" (2020) published in Cancers
  • "HCMV-controlling NKG2C+ NK cells originate from novel circulating inflammatory precursors" (2021) published in Journal of Allergy and Clinical Immunology
  • "291P: Preliminary results of cytisine therapy and tobacco cessation program in the Italian lung cancer screening program" (2025) published in Journal of Thoracic Oncology

Their work involved collaboration with several frequent coauthors, including Mariella Della Chiesa, Francesca Moretta, Letizia Muccio, Lorenzo Moretta, and Raffaella Meazza. These collaborations contributed to the breadth and depth of their investigative efforts in immune system functioning and therapeutic applications.

Moretta's research was disseminated through journals such as Cancers, Journal of Allergy and Clinical Immunology, and Journal of Thoracic Oncology, reflecting the interdisciplinary nature of their studies bridging basic immunology and clinical medicine.

Best Publications

  • Innate or Adaptive Immunity? The Example of Natural Killer Cells

    Eric Vivier;David H. Raulet;Alessandro Moretta;Michael A. Caligiuri

  • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Mübeccel Akdis

  • Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

    Cristina Bottino;Roberta Castriconi;Daniela Pende;Paola Rivera

  • RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

    Daniela Pende;Silvia Parolini;Anna Pessino;Simona Sivori

  • NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

    Massimo Vitale;Cristina Bottino;Simona Sivori;Lorenza Sanseverino

  • Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor

    Hideyuki Ikeda;Bernard Lethé;Frédéric Lehmann;Nicolas Van Baren

  • Natural killer cells and dendritic cells: rendezvous in abused tissues

    Alessandro Moretta

  • The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

    Cameron S. Brandt;Myriam Baratin;Myriam Baratin;Eugene C Yi;Jacob Kennedy

  • Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

    Roberta Castriconi;Claudia Cantoni;Mariella Della Chiesa;Massimo Vitale

  • P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

    Alessandro Moretta;Massimo Vitale;Cristina Bottino;Anna Maria Orengo

  • Unravelling natural killer cell function: triggering and inhibitory human NK receptors.

    Lorenzo Moretta;Lorenzo Moretta;Alessandro Moretta

  • Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

    Emilie Mamessier;Aude Sylvain;Marie-Laure Thibult;Gilles Houvenaeghel

  • Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity.

    Anna Pessino;Simona Sivori;Cristina Bottino;Angela Malaspina

  • The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

    Guido Ferlazzo;Dolca Thomas;Shao Lee Lin;Kiera Goodman

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

    Nicolai Wagtmann;Roberto Biassoni;Claudia Cantoni;Simonetta Verdiani

  • X-Linked Lymphoproliferative Disease 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells

    Silvia Parolini;Cristina Bottino;Michela Falco;Raffaella Augugliaro

  • p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

    Simona Sivori;Massimo Vitale;Luigia Morelli;Lorenza Sanseverino

  • Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.

    Domenico Mavilio;Gabriella Lombardo;Janet Benjamin;Diana Kim

Frequent Co-Authors

Lorenzo Moretta
Lorenzo Moretta Bambino Gesù Children's Hospital
Cristina Bottino
Cristina Bottino University of Genoa
Daniela Pende
Daniela Pende University of Genoa
Maria Cristina Mingari
Maria Cristina Mingari University of Genoa
Emanuela Marcenaro
Emanuela Marcenaro University of Genoa
Simona Sivori
Simona Sivori University of Genoa
Claudia Cantoni
Claudia Cantoni University of Genoa
Roberto Biassoni
Roberto Biassoni Istituto Giannina Gaslini
Michela Falco
Michela Falco Istituto Giannina Gaslini
Massimo Vitale
Massimo Vitale University of Genoa

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