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Massimo Vitale

Massimo Vitale

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
22515
World Ranking
11112
National Ranking
315

Overview

Massimo Vitale is affiliated with the University of Genoa in Italy. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with significant focus on Immunology and Oncology within these areas.

Their work addresses multiple specialized subfields, including Immunology, Oncology, Molecular Biology, Cancer Research, and Dermatology. The scientist's research topics cover a broad spectrum centered on immune system function and cancer, such as Immune Cell Function and Interaction, CAR-T cell therapy research, T-cell and B-cell Immunology, Cancer Immunotherapy and Biomarkers, Cancer Cells and Metastasis, Immune cells in cancer, and Hematopoietic Stem Cell Transplantation.

Massimo Vitale has published extensively in several scientific journals. Frequent publication venues include:

  • Cancers
  • Frontiers in Immunology
  • Journal for ImmunoTherapy of Cancer
  • Journal of Leukocyte Biology
  • OncoImmunology

Recent papers authored or coauthored by Massimo Vitale include:

  • Mechanisms of Resistance to NK Cell Immunotherapy, 2020, Cancers
  • Escape of tumor cells from the NK cell cytotoxic activity, 2020, Journal of Leukocyte Biology
  • Cord Blood-Derived Natural Killer Cell Exploitation in Immunotherapy Protocols: More Than a Promise?, 2022, Cancers
  • CD73/Adenosine Pathway Involvement in the Interaction of Non-Small Cell Lung Cancer Stem Cells and Bone Cells in the Pre-Metastatic Niche, 2022, International Journal of Molecular Sciences
  • Immune Checkpoint Blockade: A Strategy to Unleash the Potential of Natural Killer Cells in the Anti-Cancer Therapy, 2022, Cancers

They have collaborated frequently with other researchers, notably:

  • Monica Parodi
  • Claudia Cantoni
  • Paola Orecchia
  • Giulia Bertolini
  • Maria Cristina Mingari

Massimo Vitale's research integrates basic and clinical insights into immune cell mechanisms, particularly focusing on natural killer (NK) cells and their role in cancer therapy. Their work contributes to the understanding of immune resistance, cytotoxic activity against tumor cells, and immunotherapeutic protocols involving stem cells and checkpoint blockade strategies.

Best Publications

  • Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

    Cristina Bottino;Roberta Castriconi;Daniela Pende;Paola Rivera

  • RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

    Alessandro Moretta;Cristina Bottino;Massimo Vitale;Daniela Pende

  • NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

    Massimo Vitale;Cristina Bottino;Simona Sivori;Lorenza Sanseverino

  • Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor

    Hideyuki Ikeda;Bernard Lethé;Frédéric Lehmann;Nicolas Van Baren

  • Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

    Roberta Castriconi;Claudia Cantoni;Mariella Della Chiesa;Massimo Vitale

  • P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

    Alessandro Moretta;Massimo Vitale;Cristina Bottino;Anna Maria Orengo

  • Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

    Nicolai Wagtmann;Roberto Biassoni;Claudia Cantoni;Simonetta Verdiani

  • p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

    Simona Sivori;Massimo Vitale;Luigia Morelli;Lorenza Sanseverino

  • CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells

    Simona Sivori;Michela Falco;Mariella Della Chiesa;Simona Carlomagno

  • NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily.

    Claudia Cantoni;Cristina Bottino;Massimo Vitale;Anna Pessino

  • Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

    Alessandro Moretta;Simona Sivori;Massimo Vitale;Daniela Pende

  • NK-dependent DC maturation is mediated by TNFα and IFNγ released upon engagement of the NKp30 triggering receptor

    Massimo Vitale;Mariella Della Chiesa;Simona Carlomagno;Daniela Pende

  • The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

    Roberto Biassoni;Claudia Cantoni;Michela Falco;Simonetta Verdiani

  • Effect of tumor cells and tumor microenvironment on NK-cell function

    Massimo Vitale;Claudia Cantoni;Claudia Cantoni;Gabriella Pietra;Maria Cristina Mingari

  • Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin.

    Daniela Pende;Claudia Cantoni;Claudia Cantoni;Paola Rivera;Massimo Vitale

  • The tryptophan catabolite l-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function

    Mariella Della Chiesa;Simona Carlomagno;Guido Frumento;Mirna Balsamo

  • Human natural killer cell receptors and co‐receptors

    Roberto Biassoni;Claudia Cantoni;Claudia Cantoni;Daniela Pende;Simona Sivori;Simona Sivori

  • Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes

    Alessandro Moretta;Roberto Biassoni;Cristina Bottino;Daniela Pende

  • Effector and regulatory events during natural killer-dendritic cell interactions.

    Lorenzo Moretta;Lorenzo Moretta;Guido Ferlazzo;Cristina Bottino;Massimo Vitale

Frequent Co-Authors

Lorenzo Moretta
Lorenzo Moretta Bambino Gesù Children's Hospital
Alessandro Moretta
Alessandro Moretta University of Genoa
Cristina Bottino
Cristina Bottino University of Genoa
Claudia Cantoni
Claudia Cantoni University of Genoa
Maria Cristina Mingari
Maria Cristina Mingari University of Genoa
Daniela Pende
Daniela Pende University of Genoa
Simona Sivori
Simona Sivori University of Genoa
Michela Falco
Michela Falco Istituto Giannina Gaslini
Roberto Biassoni
Roberto Biassoni Istituto Giannina Gaslini
Emanuela Marcenaro
Emanuela Marcenaro University of Genoa

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