2026 Ennio De Gregorio: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	45	4672	4321	101	90	67	12026

Overview

Ennio De Gregorio is affiliated with Novartis in Switzerland and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work bridges several subfields, including Oncology, Infectious Diseases, Health, Modeling and Simulation, and Genetics.

Their research covers a variety of topics, notably in SARS-CoV-2 and COVID-19 research, vaccine coverage and hesitancy, COVID-19 epidemiological studies, genetic and kidney cyst diseases, renal and related cancers, fetal and pediatric neurological disorders, and CAR-T cell therapy research.

Ennio De Gregorio has published studies in several scientific venues. These include:

Proceedings of the National Academy of Sciences
Stem Cell Research
EJC Skin Cancer

Their recent papers reflect a focus on immunology, stem cell research, and cancer diagnostics:

"Vaccinology in the post−COVID-19 era," 2021, Proceedings of the National Academy of Sciences
"Production and characterisation of four Joubert syndrome patient-derived induced pluripotent stem cell (iPSC) lines with mutations in either RPGRIP1L or CPLANE1 genes," 2025, Stem Cell Research
"Targeting CD146 and CD271 in melanoma circulating tumour cells: advancing liquid biopsy technologies," 2025, EJC Skin Cancer

Collaborations feature several frequent coauthors, including Rino Rappuoli, Giuseppe Del Giudice, Sanjay Phogat, Simone Pecetta, and Mariagrazia Pizza. These recurrent partnerships suggest an interdisciplinary approach linking vaccine development, molecular biology, and oncology.

Best Publications

The Toll and Imd pathways are the major regulators of the immune response in Drosophila

Ennio De Gregorio;Paul T. Spellman;Phoebe Tzou;Gerald M. Rubin

1105
Citations
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays.

Ennio De Gregorio;Paul T. Spellman;Gerald M. Rubin;Bruno Lemaitre

885
Citations
New adjuvants for human vaccines.

M Lamine Mbow;Ennio De Gregorio;Nicholas M Valiante;Rino Rappuoli

502
Citations
Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.

Samuele Calabro;Marco Tortoli;Barbara C. Baudner;Alessandra Pacitto

498
Citations
Vaccines for the 21st century.

Isabel Delany;Rino Rappuoli;Ennio De Gregorio

482
Citations
How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.

Phoebe Tzou;Ennio De Gregorio;Bruno Lemaitre

481
Citations
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Rino Rappuoli;Matthew J. Bottomley;Ugo D’Oro;Oretta Finco

474
Citations
An immune-responsive Serpin regulates the melanization cascade in Drosophila.

Ennio De Gregorio;Sung Jun Han;Won Jae Lee;Min Ji Baek

417
Citations
Vaccines, new opportunities for a new society

Rino Rappuoli;Mariagrazia Pizza;Giuseppe Del Giudice;Ennio De Gregorio

380
Citations
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

Charles Maisonneuve;Sylvie Bertholet;Dana J. Philpott;Ennio De Gregorio

343
Citations
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders

Domenico Rosa;Giulietta Saletti;Ennio De Gregorio;Francesca Zorat

331
Citations
The path to a successful vaccine adjuvant--'the long and winding road'.

Derek T. O’Hagan;Ennio De Gregorio

330
Citations
Alum adjuvanticity: Unraveling a century old mystery

Ennio De Gregorio;Elaine Tritto;Rino Rappuoli

310
Citations
Mechanism of action of licensed vaccine adjuvants.

Elaine Tritto;Flaviana Mosca;Ennio De Gregorio

294
Citations
From empiricism to rational design: a personal perspective of the evolution of vaccine development

Ennio De Gregorio;Rino Rappuoli

251
Citations
Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.

Niels Peter H. Knudsen;Anja Olsen;Cecilia Buonsanti;Frank Follmann

249
Citations
Rapidly produced SAM ® vaccine against H7N9 influenza is immunogenic in mice

Armin Hekele;Sylvie Bertholet;Jacob Archer;Daniel G Gibson

244
Citations
Technologies to address antimicrobial resistance.

Stephen J. Baker;David J. Payne;Rino Rappuoli;Ennio De Gregorio

237
Citations
The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect.

Samuele Calabro;Elaine Tritto;Annamaria Pezzotti;Marianna Taccone

231
Citations
Translation driven by an eIF4G core domain in vivo.

Ennio De Gregorio;Thomas Preiss;Matthias W. Hentze

226
Citations
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Anja Seubert;Samuele Calabro;Laura Santini;Barbara Galli

224
Citations
Erratum: Vaccines for the twenty-first century society

Rino Rappuoli;Christian W. Mandl;Steven Black;Ennio De Gregorio

1
Citations

Frequent Co-Authors

Rino Rappuoli Imperial College London

Derek O'hagan GlaxoSmithKline (United Kingdom)

Nicholas M. Valiante Novartis (Switzerland)

Andreas Wack The Francis Crick Institute

Jeffrey B. Ulmer Novartis (Switzerland)

Bruno Lemaitre École Polytechnique Fédérale de Lausanne

Guido Grandi University of Trento

Manmohan Singh Beam Therapeutics

Matthias W. Hentze European Molecular Biology Laboratory

Christian W. Mandl Novartis (Switzerland)

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