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Jules A. Hoffmann

Jules A. Hoffmann

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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
114
Citations
64318
World Ranking
816
National Ranking
14

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award
  • 2022 - Research.com Biology and Biochemistry in France Leader Award

Overview

Jules A. Hoffmann is affiliated with the University of Strasbourg in France. Their research primarily focuses on immunology and microbiology, with a particular emphasis on the invertebrate immune response mechanisms and neurobiology related to insect physiology.

The scientist has contributed to a number of recent publications that highlight several themes in innate immunity and insect biology. Notable recent papers include:

  • A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium, 2023, published in Proceedings of the National Academy of Sciences
  • Global public health crisis response: A roundtable discussion with Professor George Fu Gao, Professor Jules A Hoffmann, Professor Chris Walzer and Professor Jiahai Lu, 2023, published in hLife
  • Toll-9 prevents the proliferation of injected oncogenic cells in adult flies, 2024, published in Journal of genetics and genomics/Journal of Genetics and Genomics
  • Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells, 2024, published in Cell Reports
  • hLife: Linking basic research and clinical applications, 2023, published in hLife

The primary fields of study represented in their work include immunology, cellular and molecular neuroscience, insect science, molecular biology, and radiology, nuclear medicine, and imaging. Subfields cover:

  • Immunology
  • Cellular and Molecular Neuroscience
  • Insect Science
  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging

Research topics commonly explored by Hoffmann include:

  • Invertebrate Immune Response Mechanisms
  • Neurobiology and Insect Physiology Research
  • Insect symbiosis and bacterial influences
  • Viral Infectious Diseases and Gene Expression in Insects
  • Insect Utilization and Effects
  • Aquaculture disease management and microbiota
  • Historical Medical Research and Treatments

Frequently publishing in venues such as Proceedings of the National Academy of Sciences, hLife, Journal of genetics and genomics/Journal of Genetics and Genomics, Cell Reports, and Biologie Aujourd hui, Hoffmann has established a consistent presence in journals that focus on interdisciplinary aspects of immunology and molecular biology related to insects.

Collaborations feature repeated partnerships with researchers like Shanming Ji, Xiaojing Zhou, Jiyong Liu, Di Chen, and Xiaoming Huang, reflecting a network of coauthors involved in related fields of genetic and immunological studies in insects and molecular pathways.

Best Publications

  • The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

    Bruno Lemaitre;Emmanuelle Nicolas;Lydia Michaut;Jean-Marc Reichhart

  • The Host Defense of Drosophila melanogaster

    Bruno Lemaitre;Jules Hoffmann

  • Phylogenetic Perspectives in Innate Immunity

    Jules A. Hoffmann;Fotis C. Kafatos;Charles A. Janeway;R. A. B. Ezekowitz

  • The immune response of Drosophila.

    Jules A. Hoffmann

  • The role of neuropeptide Y in the antiobesity action of the obese gene product.

    T W Stephens;M Basinski;P K Bristow;J M Bue-Valleskey

  • Drosophila innate immunity: an evolutionary perspective.

    Jules A. Hoffmann;Jean-Marc Reichhart

  • Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

    Bruno Lemaitre;Jean-Marc Reichhart;Jules A. Hoffmann

  • Immunity-Related Genes and Gene Families in Anopheles gambiae

    George K. Christophides;Evgeny Zdobnov;Carolina Barillas-Mury;Ewan Birney

  • The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections

    Dominique Ferrandon;Jean-Luc Imler;Charles Hetru;Jules A. Hoffmann

  • Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

    Tatiana Michel;Jean-Marc Reichhart;Jules A. Hoffmann;Julien Royet

  • The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

    Catherine Dostert;Emmanuelle Jouanguy;Emmanuelle Jouanguy;Phil Irving;Laurent Troxler

  • A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

    Bruno Lemaitre;Elisabeth Kromer-Metzger;Lydia Michaut;Emmanuelle Nicolas

  • Innate immunity of insects

    Jules A Hoffmann

  • Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia

    Phoebe Tzou;Serge Ohresser;Dominique Ferrandon;Maria Capovilla

  • The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

    Marie Gottar;Vanessa Gobert;Tatiana Michel;Marcia Belvin

  • Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

    Elena A. Levashina;Emma Langley;Clare Green;David Gubb

  • Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

    Delphine Galiana-Arnoux;Catherine Dostert;Anette Schneemann;Jules A Hoffmann

  • Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides.

    P Fehlbaum;P Bulet;L Michaut;M Lagueux

  • A genome-wide analysis of immune responses in Drosophila

    Phil Irving;Laurent Troxler;Timothy S. Heuer;Marcia Belvin

  • Toll receptors in innate immunity

    Jean-Luc Imler;Jules A. Hoffmann

Frequent Co-Authors

Charles Hetru
Charles Hetru Institute for Molecular and Cellular Biology
Jean-Marc Reichhart
Jean-Marc Reichhart University of Strasbourg
Philippe Bulet
Philippe Bulet Grenoble Alpes University
Jean-Luc Imler
Jean-Luc Imler University of Strasbourg
Bruno Lemaitre
Bruno Lemaitre École Polytechnique Fédérale de Lausanne
Philippe Georgel
Philippe Georgel University of Strasbourg
Elena A. Levashina
Elena A. Levashina Max Planck Institute for Infection Biology
Alain Van Dorsselaer
Alain Van Dorsselaer University of Strasbourg
Osamu Takeuchi
Osamu Takeuchi Kyoto University
R. Alan B. Ezekowitz
R. Alan B. Ezekowitz Harvard University

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