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Biology and Biochemistry

D-Index
57
Citations
15343
World Ranking
13629
National Ranking
5782

Overview

Neal S. Silverman is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans multiple fields with a primary focus on immunology and microbiology, biochemistry, genetics and molecular biology, and medicine.

The scientist's research interests concentrate on immunology, with significant work also in molecular biology, public health, environmental and occupational health, microbiology, and epidemiology. Their main topics of study include immune response and inflammation, interferon and immune responses, mosquito-borne diseases and control, invertebrate immune response mechanisms, inflammasome and immune disorders, CRISPR and genetic engineering, and antimicrobial peptides and activities.

Neal S. Silverman has contributed to publications in a variety of scientific venues. Notable frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, iScience, UNC Libraries, and Carbohydrate Polymers.

Their recent papers highlight diverse areas of immunology and molecular biology. Recent works include:

  • The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways (2022, Cell Reports)
  • Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer (2022, Carbohydrate Polymers)
  • Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity (2023, Immunity)
  • NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features (2020, Frontiers in Immunology)
  • Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses (2022, Nature Genetics)

Silverman's research collaborations include frequent co-authorships with several scientists, such as:

  • Kendi Okuda
  • Ravi Bharadwaj
  • Ricardo T. Gazzinelli
  • William E. Goldman
  • Siavash Mashayekh

The scientist's work reflects broad interdisciplinary integration of immunology, molecular biology, and biomedical research, underlining a focus on immune system mechanisms, inflammatory responses, and novel therapeutic approaches.

Best Publications

  • NF-kappaB signaling pathways in mammalian and insect innate immunity

    Neal S. Silverman;Tom Maniatis

  • Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology

    Nicolas Buchon;Neal S. Silverman;Sara Cherry

  • Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.

    Shelley L. Berger;Benjamin Pina;Neal S. Silverman;Gregory A. Marcus

  • Genomic insights into the Ixodes scapularis tick vector of Lyme disease

    Monika Gulia-Nuss;Monika Gulia-Nuss;Andrew B. Nuss;Andrew B. Nuss;Jason M. Meyer;Jason M. Meyer;Daniel E. Sonenshine

  • Monomeric and Polymeric Gram-Negative Peptidoglycan but Not Purified LPS Stimulate the Drosophila IMD Pathway

    Takashi Kaneko;Takashi Kaneko;William E. Goldman;Peter Mellroth;Hakan Steiner

  • PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

    Takashi Kaneko;Tamaki Yano;Kamna Aggarwal;Jae Hong Lim

  • Autophagic control of listeria through intracellular innate immune recognition in drosophila.

    Tamaki Yano;Shizuka Mita;Hiroko Ohmori;Yoshiteru Oshima

  • Caspase-mediated processing of the Drosophila NF-kappaB factor Relish.

    Svenja Stöven;Neal Silverman;Anna Junell;Marika Hedengren-Olcott

  • A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity

    Neal S. Silverman;Rui Zhou;Svenja Stoven;Niranjan Pandey;Niranjan Pandey

  • Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.

    Sophie Rutschmann;Alain C. Jung;Rui Zhou;Neal S. Silverman

  • Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

    Gregory A. Marcus;Neal S. Silverman;Shelley L. Berger;Junjiro Horiuchi

  • Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

    Lukas Bossaller;Ping-I Chiang;Christian Schmidt-Lauber;Sandhya Ganesan

  • Immune activation of NF-kappaB and JNK requires Drosophila TAK1

    Neal S. Silverman;Rui Zhou;Rachel L. Erlich;Mike Hunter

  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

    Dan Weng;Robyn Lynn Marty-Roix;Sandhya Ganesan;Megan K. Proulx

  • The Drosophila IMD pathway in the activation of the humoral immune response

    Anni Kleino;Neal S. Silverman

  • Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

    Thomas Flatt;Andreas Heyland;Florentina Rus;Ermelinda Porpiglia

  • Host-pathogen interactions in drosophila: new tricks from an old friend

    Sara Cherry;Neal S. Silverman

  • Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein

    Nickolai A. Barlev;Reyes Candau;Reyes Candau;Lian Wang;Lian Wang;Paula Darpino;Paula Darpino

  • Positive and negative regulation of the Drosophila immune response.

    Kamna Aggarwal;Neal S. Silverman

  • Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila.

    Bo Liu;Yonggang Zheng;Feng Yin;Jianzhong Yu

Frequent Co-Authors

Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
William E. Goldman
William E. Goldman University of North Carolina at Chapel Hill
Douglas T. Golenbock
Douglas T. Golenbock University of Massachusetts Chan Medical School
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Tom Maniatis
Tom Maniatis Columbia University
Marc Tatar
Marc Tatar Brown University
Edward S. Mocarski
Edward S. Mocarski Emory University
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Craig C. Mello
Craig C. Mello University of Massachusetts Chan Medical School

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