John W. R. Schwabe

Research.com Recognitions

• 2015 - Member of Academia Europaea

Overview

Best Publications

• Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

  I. Barroso;M. Gurnell;V. E. F. Crowley;M. Agostini

  1717
  Citations

• The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

  John W.R. Schwabe;Lynda Chapman;John T. Finch;Daniela Rhodes

  975
  Citations

• Protein motifs 5. Zinc fingers.

  A. Klug;J. W. R. Schwabe

  875
  Citations

• Solution structure of the DNA-binding domain of the oestrogen receptor.

  John W. R. Schwabe;David Neuhaus;Daniela Rhodes

  583
  Citations

• Mechanism of corepressor binding and release from nuclear hormone receptors.

  Laszlo Nagy;Laszlo Nagy;Hung Ying Kao;James D. Love;James D. Love;Chuan Li

  524
  Citations

• Structural basis for the activation of PPARγ by oxidized fatty acids

  Toshimasa Itoh;Louise Fairall;Kush Amin;Yuka Inaba

  524
  Citations

• Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

  Peter J. Watson;Louise Fairall;Guilherme M. Santos;John W. R. Schwabe

  513
  Citations

• Mechanism of the nuclear receptor molecular switch

  Laszlo Nagy;John W.R. Schwabe

  481
  Citations

• STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

  Attila Szanto;Balint L. Balint;Zsuzsanna S. Nagy;Zsuzsanna S. Nagy;Endre Barta;Endre Barta

  467
  Citations

• The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.

  Louise Fairall;John W. R. Schwabe;Lynda Chapman;John T. Finch

  459
  Citations

• A mutation in the thyroid hormone receptor alpha gene.

  Bochukova E;Schoenmakers N;Agostini M;Schoenmakers E

  439
  Citations

• Class I HDACs share a common mechanism of regulation by inositol phosphates.

  Christopher J. Millard;Peter J. Watson;Ivana Celardo;Yuliya Gordiyenko

  394
  Citations

• A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

  Laura S. Dickens;Robert S. Boyd;Rebekah Jukes-Jones;Michelle A. Hughes

  368
  Citations

• A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis

  M Gurnell;J M Wentworth;M Agostini;M Adams

  354
  Citations

• Zinc mining for protein domains

  John W.R. Schwabe;Aaron Klug

  335
  Citations

• Structural Basis for the Activation of Pparg by Oxidised Fatty Acids

  T. Itoh;L. Fairall;K. Amin;Y. Inaba

  331
  Citations

• St John's wort, a herbal antidepressant, activates the steroid X receptor.

  J. M. Wentworth;M. Agostini;J. Love;J. W. Schwabe

  330
  Citations

• Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

  Erik Schoenmakers;Maura Agostini;Catherine Mitchell;Nadia Schoenmakers

  316
  Citations

• Direct G Protein Modulation of Cav2 Calcium Channels

  H. William Tedford;Gerald W. Zamponi

  305
  Citations

• International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

  Gérard Benoit;Austin Cooney;Vincent Giguere;Holly Ingraham

  268
  Citations