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Biology and Biochemistry

D-Index
96
Citations
38968
World Ranking
1799
National Ranking
993

Overview

Patrick R. Griffin is affiliated with the Scripps Research Institute in the United States. Their research spans multiple disciplines within the broader fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine.

The scientist has published extensively across several subfields, including:

  • Molecular Biology
  • Immunology
  • Infectious Diseases
  • Physiology
  • Cell Biology

The main topics of their research work involve:

  • Adipose Tissue and Metabolism
  • RNA Research and Splicing
  • Peroxisome Proliferator-Activated Receptors
  • Receptor Mechanisms and Signaling
  • SARS-CoV-2 and COVID-19 Research
  • Metabolism, Diabetes, and Cancer
  • RNA and protein synthesis mechanisms

Patrick R. Griffin has contributed to the academic community through publications in several prominent venues. Their frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science
  • ACS Chemical Biology
  • SLAS DISCOVERY

Notable recent papers include:

  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor, 2020, Science
  • Molecular glue CELMoD compounds are regulators of cereblon conformation, 2022, Science
  • Structure of an AMPK complex in an inactive, ATP-bound state, 2021, Science
  • A molecular switch regulating transcriptional repression and activation of PPARγ, 2020, Nature Communications
  • Structures of the human LONP1 protease reveal regulatory steps involved in protease activation, 2021, Nature Communications

The scientist has collaborated frequently with several co-authors including:

  • Scott J. Novick
  • Timothy S. Strutzenberg
  • Theodore M. Kamenecka
  • Valentine V. Courouble
  • Jie Zheng

Patrick R. Griffin also has published books through Yale University Press, with at least two titles under the name "The Age of Atlantic Revolution," both published in 2023.

Best Publications

  • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

    D W Nicholson;A Ali;N A Thornberry;J P Vaillancourt

  • A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

    Andrew D. Howard;Scott D. Feighner;Doris F. Cully;Joseph P. Arena

  • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

    Jang Hyun Choi;Alexander S. Banks;Jennifer L. Estall;Shingo Kajimura

  • Peptide mass maps: a highly informative approach to protein identification.

    J.R. Yates;S. Speicher;P.R. Griffin;T. Hunkapiller

  • Peroxynitrite reductase activity of bacterial peroxiredoxins

    Ruslana Bryk;Patrick Griffin;Carl Nathan

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

    Glenn R. Masson;John E. Burke;Natalie G. Ahn;Ganesh S. Anand

  • Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Fen Fen Soon;Fen Fen Soon;Ley Moy Ng;Ley Moy Ng;X. Edward Zhou;Graham M. West

  • Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

    Bei Zhang;Gino Salituro;Deborah Szalkowski;Zhihua Li

  • Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

    Jang Hyun Choi;Alexander S. Banks;Theodore M. Kamenecka;Scott A. Busby

  • Suppression of TH17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

    Laura A. Solt;P. Naresh Kumar;Philippe Nuhant;Yongjun Wang

  • Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

    X. Edward Zhou;X. Edward Zhou;Yuanzheng He;Parker W. de Waal;Xiang Gao

  • Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

    Hyeonwoo Kim;Christiane D. Wrann;Mark Jedrychowski;Sara Vidoni

  • Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

    Elaine Kirschke;Devrishi Goswami;Daniel Southworth;Patrick R. Griffin

  • HP1 reshapes nucleosome core to promote phase separation of heterochromatin

    S. Sanulli;M. J. Trnka;V. Dharmarajan;R. W. Tibble

  • Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones.

    Nancy A. Thornberry;Erin P. Peterson;Justin J. Zhao;Andrew D. Howard

  • The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-α/γ Inverse Agonist

    Naresh Kumar;Laura A. Solt;Juliana J. Conkright;Yongjun Wang

  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis

    Li Ye;Sandra Kleiner;Jun Wu;Rajan Sah

  • Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry

    Michael J Chalmers;Scott A Busby;Bruce D Pascal;Yuanjun He

  • HDX workbench: software for the analysis of H/D exchange MS data.

    Bruce D. Pascal;Scooter Willis;Janelle L. Lauer;Rachelle R. Landgraf

Frequent Co-Authors

Michael D. Cameron
Michael D. Cameron Scripps Research Institute
Michael J. Chalmers
Michael J. Chalmers Eli Lilly (United States)
William R. Roush
William R. Roush Scripps Research Institute
Thomas P. Burris
Thomas P. Burris Washington University in St. Louis
Donald F. Hunt
Donald F. Hunt University of Virginia
H. Eric Xu
H. Eric Xu Chinese Academy of Sciences
Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Karsten Melcher
Karsten Melcher Van Andel Institute
John A. Katzenellenbogen
John A. Katzenellenbogen University of Illinois at Urbana-Champaign
Raymond C. Stevens
Raymond C. Stevens University of Southern California

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