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Chemistry

D-Index
85
Citations
25376
World Ranking
2680
National Ranking
927

Research.com Recognitions

  • 2009 - Fellow of the American Chemical Society
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Ernest Guenther Award, American Chemical Society (ACS)
  • 1982 - Fellow of Alfred P. Sloan Foundation

Overview

William R. Roush is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable focus on Molecular Biology, Oncology, Cancer Research, Organic Chemistry, and Genetics as subfields.

The scientist's work covers several major topics, including:

  • Protease and Inhibitor Mechanisms
  • Peptidase Inhibition and Analysis
  • Cancer-related Molecular Pathways
  • Inflammasome and Immune Disorders
  • Multiple Myeloma Research and Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research

Frequent publication venues where William R. Roush has contributed include:

  • Journal of Medicinal Chemistry
  • Frontiers in Molecular Biosciences
  • Cancer Research
  • SSRN Electronic Journal
  • Blood Advances

Selected recent papers authored or coauthored by William R. Roush are:

  • The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells, 2020, Blood Advances
  • The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis, 2021, Frontiers in Molecular Biosciences
  • Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors, 2020, ACS Infectious Diseases
  • Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival, 2021, Cancer Research
  • Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor, 2025, Journal of Medicinal Chemistry

Frequent coauthors working with William R. Roush include:

  • Andrii Monastyrskyi
  • Derek R. Duckett
  • Rita Fuerst
  • Jun Yong Choi
  • Anna M. Knapinska

Awards received by William R. Roush during their career comprise:

  • Fellow of the American Chemical Society, 2009
  • Fellow of the American Association for the Advancement of Science (AAAS), 2006
  • Ernest Guenther Award, American Chemical Society (ACS), 2004
  • Fellow of Alfred P. Sloan Foundation, 1982

Best Publications

  • Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

    Mary A. Blanchette;William Choy;Jeffery T. Davis;Amy P. Essenfeld

  • Nucleophilic Phosphine Organocatalysis

    Joey L. Methot;William R. Roush

  • Systems analysis of intracellular pH vulnerabilities for cancer therapy.

    Erez Persi;Erez Persi;Miquel Duran-Frigola;Mehdi Damaghi;William R. Roush

  • Asymmetric synthesis using diisopropyl tartrate modified (E)- and (Z)-crotylboronates: preparation of the chiral crotylboronates and reactions with achiral aldehydes

    William R. Roush;Kaori Ando;Daniel B. Powers;Alan D. Palkowitz

  • Diastereo- and enantioselective aldehyde addition reactions of 2-allyl-1,3,2-dioxaborolane-4,5-dicarboxylic esters, a useful class of tartrate ester modified allylboronates

    William R. Roush;Alan E. Walts;Lee K. Hoong

  • Acyclic diastereoselective synthesis using tartrate ester-modified crotylboronates. Double asymmetric reactions with .alpha.-methyl chiral aldehydes and synthesis of the C(19)-C(29) segment of rifamycin S

    William R. Roush;Alan D. Palkowitz;Kaori Ando

  • Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

    William R. Roush;Stephen L. Gwaltney;Jianming Cheng;Karl A. Scheidt

  • Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

    Kathrin Renner;Christina Bruss;Annette Schnell;Gudrun Koehl

  • Tris(dimethylamino)sulfonium Difluorotrimethylsilicate, a Mild Reagent for the Removal of Silicon Protecting Groups

    Karl A. Scheidt;Hou Chen;Bruce C. Follows;Sherry R. Chemler

  • The Vinylogous Intramolecular Morita−Baylis−Hillman Reaction: Synthesis of Functionalized Cyclopentenes and Cyclohexenes with Trialkylphosphines as Nucleophilic Catalysts

    Scott A. Frank;Dustin J. Mergott;William R. Roush

  • CONCERNING THE DIASTEREOFACIAL SELECTIVITY OF THE ALDOL REACTIONS OF ALPHA-METHYL CHIRAL ALDEHYDES AND LITHIUM AND BORON PROPIONATE ENOLATES

    William R. Roush

  • Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.

    Conor R Caffrey;Elizabeth Hansell;Kimberley D Lucas;Linda S Brinen

  • A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells

    Davide Gianni;Nicolas Taulet;Hui Zhang;Celine DerMardirossian

  • Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.

    Bhaskar R. Shenai;Belinda J. Lee;Alejandro Alvarez-Hernandez;Pek Y. Chong

  • Total synthesis of +-superstolide A.

    Mariola Tortosa;Neal A. Yakelis;William R. Roush

  • Enantioselective Synthesis of 1,5-anti- and 1,5-syn-Diols Using a Highly Diastereoselective One-Pot Double Allylboration Reaction Sequence

    Eric M. Flamme;William R. Roush

  • Stereochemistry of the reactions of substituted allylboronates with chiral aldehydes. Factors influencing aldehyde diastereofacial selectivity

    William R. Roush;Michael A. Adam;Alan E. Walts;David J. Harris

  • Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine

    William R. Roush;Michael A. Adam

  • Asymmetric synthesis using tartrate ester modified allylboronates. 1. Factors influencing stereoselectivity

    William R. Roush;Lee K. Hoong;Michelle A. J. Palmer;Jae Chan Park

  • Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

    Yongjun Wang;Naresh Kumar;Philippe Nuhant;Michael D. Cameron

Frequent Co-Authors

Michael D. Cameron
Michael D. Cameron Scripps Research Institute
Louis Fieser
Louis Fieser Harvard University
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
James H. McKerrow
James H. McKerrow University of California, San Diego
A. Donny Strosberg
A. Donny Strosberg Université Paris Cité
Thomas P. Burris
Thomas P. Burris Washington University in St. Louis
Hugh Rosen
Hugh Rosen Scripps Research Institute
John L. Cleveland
John L. Cleveland Moffitt Cancer Center
Karl A. Scheidt
Karl A. Scheidt Northwestern University
Gary D. Glick
Gary D. Glick University of Michigan–Ann Arbor

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