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William R. Roush

D-Index & Metrics

Chemistry

D-Index
85
Citations
25376
World Ranking
2680
National Ranking
926

William R. Roush publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where William R. Roush sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 869 publications — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

William R. Roush D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where William R. Roush sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 85 D-Index — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2009 - Fellow of the American Chemical Society
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Ernest Guenther Award, American Chemical Society (ACS)
  • 1982 - Fellow of Alfred P. Sloan Foundation

Overview

William R. Roush is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable focus on Molecular Biology, Oncology, Cancer Research, Organic Chemistry, and Genetics as subfields.

The scientist's work covers several major topics, including:

  • Protease and Inhibitor Mechanisms
  • Peptidase Inhibition and Analysis
  • Cancer-related Molecular Pathways
  • Inflammasome and Immune Disorders
  • Multiple Myeloma Research and Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research

Frequent publication venues where William R. Roush has contributed include:

  • Journal of Medicinal Chemistry
  • Frontiers in Molecular Biosciences
  • Cancer Research
  • SSRN Electronic Journal
  • Blood Advances

Selected recent papers authored or coauthored by William R. Roush are:

  • The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells, 2020, Blood Advances
  • The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis, 2021, Frontiers in Molecular Biosciences
  • Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors, 2020, ACS Infectious Diseases
  • Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival, 2021, Cancer Research
  • Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor, 2025, Journal of Medicinal Chemistry

Frequent coauthors working with William R. Roush include:

  • Andrii Monastyrskyi
  • Derek R. Duckett
  • Rita Fuerst
  • Jun Yong Choi
  • Anna M. Knapinska

Awards received by William R. Roush during their career comprise:

  • Fellow of the American Chemical Society, 2009
  • Fellow of the American Association for the Advancement of Science (AAAS), 2006
  • Ernest Guenther Award, American Chemical Society (ACS), 2004
  • Fellow of Alfred P. Sloan Foundation, 1982

Best Publications

  • Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

    Mary A. Blanchette;William Choy;Jeffery T. Davis;Amy P. Essenfeld

  • Nucleophilic Phosphine Organocatalysis

    Joey L. Methot;William R. Roush

  • Systems analysis of intracellular pH vulnerabilities for cancer therapy.

    Erez Persi;Erez Persi;Miquel Duran-Frigola;Mehdi Damaghi;William R. Roush

  • Asymmetric synthesis using diisopropyl tartrate modified (E)- and (Z)-crotylboronates: preparation of the chiral crotylboronates and reactions with achiral aldehydes

    William R. Roush;Kaori Ando;Daniel B. Powers;Alan D. Palkowitz

  • Diastereo- and enantioselective aldehyde addition reactions of 2-allyl-1,3,2-dioxaborolane-4,5-dicarboxylic esters, a useful class of tartrate ester modified allylboronates

    William R. Roush;Alan E. Walts;Lee K. Hoong

  • Acyclic diastereoselective synthesis using tartrate ester-modified crotylboronates. Double asymmetric reactions with .alpha.-methyl chiral aldehydes and synthesis of the C(19)-C(29) segment of rifamycin S

    William R. Roush;Alan D. Palkowitz;Kaori Ando

  • Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

    William R. Roush;Stephen L. Gwaltney;Jianming Cheng;Karl A. Scheidt

  • Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

    Kathrin Renner;Christina Bruss;Annette Schnell;Gudrun Koehl

  • Tris(dimethylamino)sulfonium Difluorotrimethylsilicate, a Mild Reagent for the Removal of Silicon Protecting Groups

    Karl A. Scheidt;Hou Chen;Bruce C. Follows;Sherry R. Chemler

  • The Vinylogous Intramolecular Morita−Baylis−Hillman Reaction: Synthesis of Functionalized Cyclopentenes and Cyclohexenes with Trialkylphosphines as Nucleophilic Catalysts

    Scott A. Frank;Dustin J. Mergott;William R. Roush

  • CONCERNING THE DIASTEREOFACIAL SELECTIVITY OF THE ALDOL REACTIONS OF ALPHA-METHYL CHIRAL ALDEHYDES AND LITHIUM AND BORON PROPIONATE ENOLATES

    William R. Roush

  • Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.

    Conor R Caffrey;Elizabeth Hansell;Kimberley D Lucas;Linda S Brinen

  • A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells

    Davide Gianni;Nicolas Taulet;Hui Zhang;Celine DerMardirossian

  • Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.

    Bhaskar R. Shenai;Belinda J. Lee;Alejandro Alvarez-Hernandez;Pek Y. Chong

  • Total synthesis of +-superstolide A.

    Mariola Tortosa;Neal A. Yakelis;William R. Roush

  • Enantioselective Synthesis of 1,5-anti- and 1,5-syn-Diols Using a Highly Diastereoselective One-Pot Double Allylboration Reaction Sequence

    Eric M. Flamme;William R. Roush

  • Stereochemistry of the reactions of substituted allylboronates with chiral aldehydes. Factors influencing aldehyde diastereofacial selectivity

    William R. Roush;Michael A. Adam;Alan E. Walts;David J. Harris

  • Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine

    William R. Roush;Michael A. Adam

  • Asymmetric synthesis using tartrate ester modified allylboronates. 1. Factors influencing stereoselectivity

    William R. Roush;Lee K. Hoong;Michelle A. J. Palmer;Jae Chan Park

  • Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

    Yongjun Wang;Naresh Kumar;Philippe Nuhant;Michael D. Cameron

Frequent Co-Authors

Michael D. Cameron
Michael D. Cameron Scripps Research Institute
Louis Fieser
Louis Fieser Harvard University
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
James H. McKerrow
James H. McKerrow University of California, San Diego
A. Donny Strosberg
A. Donny Strosberg Université Paris Cité
Thomas P. Burris
Thomas P. Burris Washington University in St. Louis
Hugh Rosen
Hugh Rosen Scripps Research Institute
John L. Cleveland
John L. Cleveland Moffitt Cancer Center
Karl A. Scheidt
Karl A. Scheidt Northwestern University
Gary D. Glick
Gary D. Glick University of Michigan–Ann Arbor

External Links

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