World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
17699
World Ranking
10615
National Ranking
4611

Overview

Karsten Melcher is affiliated with the Van Andel Institute in the United States and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work emphasizes Molecular Biology as a subfield, with additional focus areas including Cellular and Molecular Neuroscience, Endocrinology, Diabetes and Metabolism, Surgery, and Computational Theory and Mathematics.

The main topics of Karsten Melcher's research involve Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Neuroscience and Neuropharmacology Research, Neurotransmitter Receptor Influence on Behavior, Pancreatic function and diabetes, Epigenetics and DNA Methylation, and Metabolism, Diabetes, and Cancer.

Some of their recent papers include:

  • Structural insights into the lipid and ligand regulation of serotonin receptors (2021), published in Nature
  • Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex (2020), published in Cell
  • Structural insights into the human D1 and D2 dopamine receptor signaling complexes (2021), published in Cell
  • Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy (2020), published in Nature Communications
  • Molecular recognition of morphine and fentanyl by the human μ-opioid receptor (2022), published in Cell

Frequent co-authors of Karsten Melcher include:

  • X. Edward Zhou
  • H. Eric Xu
  • Yi Jiang
  • Ting-Hai Xu
  • Chunyou Mao

The scientist has multiple publications in key venues such as:

  • Cell
  • Nature Communications
  • EMPIAR dataset
  • UNC Libraries
  • Nature

Best Publications

  • Amyloid beta: structure, biology and structure-based therapeutic development

    Guo Fang Chen;Ting Hai Xu;Yan Yan;Yu Ren Zhou

  • DWARF 53 acts as a repressor of strigolactone signalling in rice

    Liang Jiang;Xue Liu;Guosheng Xiong;Huihui Liu

  • A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

    Karsten Melcher;Ley-Moy Ng;Ley-Moy Ng;X. Edward Zhou;Fen-Fen Soon;Fen-Fen Soon

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • Androgen receptor: structure, role in prostate cancer and drug discovery

    MH Eileen Tan;Jun Li;H Eric Xu;Karsten Melcher

  • Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Fen Fen Soon;Fen Fen Soon;Ley Moy Ng;Ley Moy Ng;X. Edward Zhou;Graham M. West

  • Structural Basis for Molecular Recognition at Serotonin Receptors

    Chong Wang;Yi Jiang;Yi Jiang;Jinming Ma;Jinming Ma;Huixian Wu

  • Structural basis for molecular recognition of folic acid by folate receptors

    Chen Chen;Chen Chen;Jiyuan Ke;X. Edward Zhou;Wei Yi

  • Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

    X. Edward Zhou;X. Edward Zhou;Yuanzheng He;Parker W. de Waal;Xiang Gao

  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling

    Feng Zhang;Jian Yao;Jian Yao;Jiyuan Ke;Li Zhang

  • Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14

    Li-Hua Zhao;X Edward Zhou;Zhong-Shan Wu;Zhong-Shan Wu;Wei Yi

  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

    Yanyong Kang;Oleg Kuybeda;Parker W. de Waal;Somnath Mukherjee

  • GAL4 Interacts with TATA-Binding Protein and Coactivators

    Karsten Melcher;Stephen A. Johnston

  • A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein

    Jonathan C. Swaffield;Karsten Melcher;Stephen Albert Johnston

  • Structure and dynamics of the active human parathyroid hormone receptor-1.

    L.H. Zhao;S. Ma;I. Sutkeviciute;D.D. Shen

  • Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

    Changrui Xing;Youwen Zhuang;Youwen Zhuang;Ting Hai Xu;Zhiwei Feng

  • Abscisic acid perception and signaling: structural mechanisms and applications

    Ley Moy Ng;Karsten Melcher;Bin Tean Teh;H Eric Xu

  • Structural insights into the lipid and ligand regulation of serotonin receptors

    Peiyu Xu;Peiyu Xu;Sijie Huang;Sijie Huang;Huibing Zhang;Chunyou Mao

  • An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.

    Minjie Cao;Xue Liu;Yan Zhang;Xiaoqian Xue;Xiaoqian Xue

  • Structural basis of AMPK regulation by adenine nucleotides and glycogen

    Xiaodan Li;Lili Wang;X Edward Zhou;Jiyuan Ke

Frequent Co-Authors

H. Eric Xu
H. Eric Xu Chinese Academy of Sciences
Jian-Kang Zhu
Jian-Kang Zhu Southern University of Science and Technology
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Jiayang Li
Jiayang Li Chinese Academy of Sciences
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Donghai Wu
Donghai Wu Cornell University

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