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Denise Wootten

Denise Wootten

Monash University
Australia

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9987
World Ranking
16179
National Ranking
454

Denise Wootten publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Denise Wootten sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 170 publications — 36th percentile

36% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Denise Wootten D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Denise Wootten sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Denise Wootten is currently affiliated with Monash University in Australia and has a significant research footprint in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work extensively covers Molecular Biology, Cellular and Molecular Neuroscience, and Endocrinology, Diabetes and Metabolism, among other subfields.

The scientist's research focuses primarily on receptor mechanisms and signaling, neuropeptides and animal physiology, and diabetes treatment and management. They also engage with topics related to monoclonal and polyclonal antibodies research, pancreatic function and diabetes, signaling pathways in disease, and lipid membrane structure and behavior.

Denise Wootten has published multiple papers in prestigious venues. Noteworthy recent publications include:

  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists (2020, Molecular Cell)
  • Activation of the GLP-1 receptor by a non-peptidic agonist (2020, Nature)
  • Structural basis of G s and G i recognition by the human glucagon receptor (2020, Science)
  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia (2021, Nature)
  • Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation (2020, Molecular Cell)

The scientist frequently collaborates with several coauthors, including Patrick M. Sexton, Matthew J. Belousoff, Radostin Danev, Arthur Christopoulos, and Peishen Zhao. Their publishing record shows a strong presence in key scientific journals and preprint platforms such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Biochemical Pharmacology
  • Molecular Cell
  • Science

The research output is rooted in an interdisciplinary approach, intersecting molecular biology and neuroscience with clinical fields focused on disease mechanisms and management, notably diabetes. This allows the scientist to address critical questions related to receptor function, signaling pathways, and novel therapeutic targets. The topics of receptor mechanisms and neuropeptides appear prominently in their work, reflecting a specialization in cellular communication and physiological regulation.

Denise Wootten's contributions span foundational studies on receptor activation by ligands of various natures, including peptides and non-peptidic molecules, which are relevant to understanding human glucagon and GLP-1 receptors involved in metabolic control.

The scientist's research profile indicates a sustained engagement with both theoretical and applied aspects of molecular biology and pharmacology, contributing to a broader understanding of signaling pathways that influence health and disease.

Best Publications

  • Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Denise L Wootten;Arthur Christopoulos;Maria Marti-Solano;M. Madan Babu

  • Emerging paradigms in GPCR allostery: implications for drug discovery

    Denise Laura Wootten;Arthur Christopoulos;Patrick Sexton

  • Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

    Yi Lynn Liang;Maryam Khoshouei;Mazdak Radjainia;Yan Zhang

  • Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

    Chris de Graaf;Dan Donnelly;Denise Wootten;Jesper Lau

  • Lifting the lid on GPCRs: the role of extracellular loops

    M Wheatley;D Wootten;MT Conner;J Simms

  • Structure of the adenosine-bound human adenosine A 1 receptor-G i complex.

    Christopher J. Draper-Joyce;Maryam Khoshouei;Maryam Khoshouei;David M. Thal;Yi Lynn Liang

  • Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

    Yi Lynn Liang;Maryam Khoshouei;Alisa Glukhova;Sebastian G.B. Furness

  • Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

    Cassandra Koole;Denise Wootten;John Simms;Celine Valant

  • Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

    Denise Laura Wootten;John Watson Simms;Laurence J Miller;Arthur Christopoulos

  • Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor

    Yi Lynn Liang;Maryam Khoshouei;Maryam Khoshouei;Giuseppe Deganutti;Alisa Glukhova

  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

    Xin Zhang;Matthew J. Belousoff;Peishen Zhao;Albert J. Kooistra

  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

    Christopher J. Draper-Joyce;Christopher J. Draper-Joyce;Rebecca Bhola;Jinan Wang;Apurba Bhattarai

  • The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

    Denise Wootten;Christopher A. Reynolds;Kevin J. Smith;Juan C. Mobarec

  • Activation of the GLP-1 receptor by a non-peptidic agonist

    Peishen Zhao;Yi Lynn Liang;Matthew J. Belousoff;Giuseppe Deganutti

  • Structural basis of Gs and Gi recognition by the human glucagon receptor

    Anna Qiao;Shuo Han;Xinmei Li;Zhixin Li

  • Allostery and biased agonism at class b g protein-coupled receptors

    Denise Wootten;Laurence J. Miller;Cassandra Koole;Cassandra Koole;Arthur Christopoulos

  • Ligand-dependent modulation of G protein conformation alters drug efficacy

    Sebastian George Barton Furness;Yi-Lynn Liang;Cameron James Nowell;Michelle Louise Halls

  • Rules of Engagement: GPCRs and G Proteins.

    Alisa Glukhova;Christopher J Draper-Joyce;Roger K. Sunahara;Arthur Christopoulos

  • Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination

    Yi-Lynn Liang;Peishen Zhao;Christopher James Draper-Joyce;Jo-Anne Baltos

  • 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

    Y.L. Liang;M. Khoshouei;A. Glukhova;S.G.B. Furness

Frequent Co-Authors

Patrick M. Sexton
Patrick M. Sexton Monash University
Arthur Christopoulos
Arthur Christopoulos Monash University
Laurence J. Miller
Laurence J. Miller Mayo Clinic
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Debbie L. Hay
Debbie L. Hay University of Otago
Francis S. Willard
Francis S. Willard Eli Lilly (United States)
Roger J. Summers
Roger J. Summers Monash University
Wolfgang Baumeister
Wolfgang Baumeister Max Planck Society
David R. Poyner
David R. Poyner Aston University
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison

External Links

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Best Scientists Citing Denise Wootten

Ming-Wei Wang

Ming-Wei Wang

Chinese Academy of Sciences

Publications: 58

H. Eric Xu

H. Eric Xu

Chinese Academy of Sciences

Publications: 56

Debbie L. Hay

Debbie L. Hay

University of Otago

Publications: 49

Arthur Christopoulos

Arthur Christopoulos

Monash University

Publications: 48

David R. Poyner

David R. Poyner

Aston University

Publications: 42

Patrick M. Sexton

Patrick M. Sexton

Monash University

Publications: 39

Brian K. Kobilka

Brian K. Kobilka

Stanford University

Publications: 34

Raymond C. Stevens

Raymond C. Stevens

University of Southern California

Publications: 33

Asuka Inoue

Asuka Inoue

Tohoku University

Publications: 29

Hualiang Jiang

Hualiang Jiang

Chinese Academy of Sciences

Publications: 25

Guy A. Rutter

Guy A. Rutter

Imperial College London

Publications: 25

Robert J. Lefkowitz

Robert J. Lefkowitz

Duke University

Publications: 24

Chris de Graaf

Chris de Graaf

Vrije Universiteit Amsterdam

Publications: 19

Gebhard F. X. Schertler

Gebhard F. X. Schertler

Paul Scherrer Institute

Publications: 17

Stephen J. Hill

Stephen J. Hill

University of Nottingham

Publications: 16

Mette M. Rosenkilde

Mette M. Rosenkilde

University of Copenhagen

Publications: 16

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