World's Best Scientists 2026 revealed!
Denise Wootten

Denise Wootten

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9987
World Ranking
16179
National Ranking
454

Overview

Denise Wootten is currently affiliated with Monash University in Australia and has a significant research footprint in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work extensively covers Molecular Biology, Cellular and Molecular Neuroscience, and Endocrinology, Diabetes and Metabolism, among other subfields.

The scientist's research focuses primarily on receptor mechanisms and signaling, neuropeptides and animal physiology, and diabetes treatment and management. They also engage with topics related to monoclonal and polyclonal antibodies research, pancreatic function and diabetes, signaling pathways in disease, and lipid membrane structure and behavior.

Denise Wootten has published multiple papers in prestigious venues. Noteworthy recent publications include:

  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists (2020, Molecular Cell)
  • Activation of the GLP-1 receptor by a non-peptidic agonist (2020, Nature)
  • Structural basis of G s and G i recognition by the human glucagon receptor (2020, Science)
  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia (2021, Nature)
  • Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation (2020, Molecular Cell)

The scientist frequently collaborates with several coauthors, including Patrick M. Sexton, Matthew J. Belousoff, Radostin Danev, Arthur Christopoulos, and Peishen Zhao. Their publishing record shows a strong presence in key scientific journals and preprint platforms such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Biochemical Pharmacology
  • Molecular Cell
  • Science

The research output is rooted in an interdisciplinary approach, intersecting molecular biology and neuroscience with clinical fields focused on disease mechanisms and management, notably diabetes. This allows the scientist to address critical questions related to receptor function, signaling pathways, and novel therapeutic targets. The topics of receptor mechanisms and neuropeptides appear prominently in their work, reflecting a specialization in cellular communication and physiological regulation.

Denise Wootten's contributions span foundational studies on receptor activation by ligands of various natures, including peptides and non-peptidic molecules, which are relevant to understanding human glucagon and GLP-1 receptors involved in metabolic control.

The scientist's research profile indicates a sustained engagement with both theoretical and applied aspects of molecular biology and pharmacology, contributing to a broader understanding of signaling pathways that influence health and disease.

Best Publications

  • Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Denise L Wootten;Arthur Christopoulos;Maria Marti-Solano;M. Madan Babu

  • Emerging paradigms in GPCR allostery: implications for drug discovery

    Denise Laura Wootten;Arthur Christopoulos;Patrick Sexton

  • Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

    Yi Lynn Liang;Maryam Khoshouei;Mazdak Radjainia;Yan Zhang

  • Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

    Chris de Graaf;Dan Donnelly;Denise Wootten;Jesper Lau

  • Lifting the lid on GPCRs: the role of extracellular loops

    M Wheatley;D Wootten;MT Conner;J Simms

  • Structure of the adenosine-bound human adenosine A 1 receptor-G i complex.

    Christopher J. Draper-Joyce;Maryam Khoshouei;Maryam Khoshouei;David M. Thal;Yi Lynn Liang

  • Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

    Yi Lynn Liang;Maryam Khoshouei;Alisa Glukhova;Sebastian G.B. Furness

  • Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

    Cassandra Koole;Denise Wootten;John Simms;Celine Valant

  • Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

    Denise Laura Wootten;John Watson Simms;Laurence J Miller;Arthur Christopoulos

  • Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor

    Yi Lynn Liang;Maryam Khoshouei;Maryam Khoshouei;Giuseppe Deganutti;Alisa Glukhova

  • Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

    Xin Zhang;Matthew J. Belousoff;Peishen Zhao;Albert J. Kooistra

  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

    Christopher J. Draper-Joyce;Christopher J. Draper-Joyce;Rebecca Bhola;Jinan Wang;Apurba Bhattarai

  • The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

    Denise Wootten;Christopher A. Reynolds;Kevin J. Smith;Juan C. Mobarec

  • Activation of the GLP-1 receptor by a non-peptidic agonist

    Peishen Zhao;Yi Lynn Liang;Matthew J. Belousoff;Giuseppe Deganutti

  • Structural basis of Gs and Gi recognition by the human glucagon receptor

    Anna Qiao;Shuo Han;Xinmei Li;Zhixin Li

  • Allostery and biased agonism at class b g protein-coupled receptors

    Denise Wootten;Laurence J. Miller;Cassandra Koole;Cassandra Koole;Arthur Christopoulos

  • Ligand-dependent modulation of G protein conformation alters drug efficacy

    Sebastian George Barton Furness;Yi-Lynn Liang;Cameron James Nowell;Michelle Louise Halls

  • Rules of Engagement: GPCRs and G Proteins.

    Alisa Glukhova;Christopher J Draper-Joyce;Roger K. Sunahara;Arthur Christopoulos

  • Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination

    Yi-Lynn Liang;Peishen Zhao;Christopher James Draper-Joyce;Jo-Anne Baltos

  • 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

    Y.L. Liang;M. Khoshouei;A. Glukhova;S.G.B. Furness

Frequent Co-Authors

Patrick M. Sexton
Patrick M. Sexton Monash University
Arthur Christopoulos
Arthur Christopoulos Monash University
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Debbie L. Hay
Debbie L. Hay University of Otago
Francis S. Willard
Francis S. Willard Eli Lilly (United States)
Roger J. Summers
Roger J. Summers Monash University
Wolfgang Baumeister
Wolfgang Baumeister Max Planck Society
David R. Poyner
David R. Poyner Aston University
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison

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