World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
117
Citations
74514
World Ranking
708
National Ranking
450

Medicine

D-Index
117
Citations
74508
World Ranking
4123
National Ranking
2258

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Peter Tontonoz is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple interconnected areas within medicine and biochemistry, genetics, and molecular biology, with a significant focus on molecular biology and surgery as well as physiology, public health, environmental and occupational health, and cancer research.

Their published work addresses topics including:

  • Cholesterol and Lipid Metabolism
  • Adipose Tissue and Metabolism
  • Lipid Metabolism and Biosynthesis
  • Public Health Policies and Education
  • Ethics in Clinical Research
  • Peroxisome Proliferator-Activated Receptors
  • Zoonotic Diseases and Public Health

Recent publications by Peter Tontonoz include:

  • "Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis," 2020, Cell Metabolism
  • "Hepatic transcriptional responses to fasting and feeding," 2021, Genes & Development
  • "Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling," 2020, Science Translational Medicine
  • "Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins," 2020, Nature Immunology
  • "Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle," 2021, Journal of Clinical Investigation

Frequent coauthors who have collaborated extensively with Peter Tontonoz include:

  • Xiao Xu
  • John P. Kennelly
  • Alessandra Ferrari
  • Stephen G. Young
  • Patrick D. Schloss

The scientist's work is often published in established venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Clinical Investigation
  • Molecular and Cellular Biology
  • Nature Metabolism

Peter Tontonoz's scholarly contributions have been recognized by their peers, including election as a Member of the National Academy of Sciences in 2020 and as a Member of the Association of American Physicians. The combination of their fields of study, main research topics, and collaborative network underscores their ongoing role in advancing biomedical and clinical research related to metabolism, lipid biology, and associated health outcomes.

Best Publications

  • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

    Barry M. Forman;Barry M. Forman;Peter Tontonoz;Jasmine Chen;Regina P. Brun

  • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

    Peter Tontonoz;Erding Hu;Bruce M. Spiegelman

  • mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

    Peter Tontonoz;Erding Hu;Reed A. Graves;Adriane I. Budavari

  • Fat and beyond: the diverse biology of PPARgamma.

    Peter Tontonoz;Bruce M Spiegelman

  • PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

    Peter Tontonoz;Laszlo Nagy;Laszlo Nagy;Jacqueline G.A Alvarez;Vilmos A Thomazy

  • Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

    Laszlo Nagy;Laszlo Nagy;Peter Tontonoz;Peter Tontonoz;Jacqueline G.A Alvarez;Hongwu Chen

  • A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

    Ajay Chawla;William A. Boisvert;Chih Hao Lee;Bryan A. Laffitte

  • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

    Peter J. Tontonoz;Sean B. Joseph;Antonio Castrillo

  • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation.

    Ajay Chawla;Yaacov Barak;Laszlo Nagy;Debbie Liao

  • Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

    Asha Venkateswaran;Bryan A. Laffitte;Sean B. Joseph;Puiying A. Mak

  • ApoE Promotes the Proteolytic Degradation of Aβ

    Qingguang Jiang;C.Y. Daniel Lee;Shweta Mandrekar;Brandy Wilkinson

  • Terminal Differentiation of Human Breast Cancer through PPARγ

    Elisabetta Mueller;Pasha Sarraf;Peter Tontonoz;Peter Tontonoz;Ronald M. Evans;Ronald M. Evans

  • Synthetic LXR ligand inhibits the development of atherosclerosis in mice

    Sean B. Joseph;Elaine McKilligin;Liming Pei;Michael A. Watson

  • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

    Heidi R. Kast;Bryan Goodwin;Paul T. Tarr;Stacey A. Jones

  • Liver X receptors as integrators of metabolic and inflammatory signaling.

    Noam Zelcer;Peter Tontonoz

  • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

    Noam Zelcer;Cynthia Hong;Rima Boyadjian;Peter Tontonoz

  • Integration of metabolism and inflammation by lipid-activated nuclear receptors.

    Steven J. Bensinger;Peter Tontonoz

  • Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

    Sean B. Joseph;Bryan A. Laffitte;Parthive H. Patel;Michael A. Watson

  • Liver X Receptor Signaling Pathways in Cardiovascular Disease

    Peter Tontonoz;David J. Mangelsdorf

  • Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

    Anna C. Calkin;Peter Tontonoz

Frequent Co-Authors

Antonio Castrillo
Antonio Castrillo Spanish National Research Council
Stephen G. Young
Stephen G. Young University of California, Los Angeles
Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Karen Reue
Karen Reue University of California, Los Angeles
Loren G. Fong
Loren G. Fong University of California, Los Angeles
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Aldons J. Lusis
Aldons J. Lusis University of California, Los Angeles
Patrick D. Schloss
Patrick D. Schloss University of Michigan–Ann Arbor
Harold L. Drake
Harold L. Drake University of Bayreuth
Susan T. Lovett
Susan T. Lovett Brandeis University

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