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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
11693
World Ranking
17900
National Ranking
795

Overview

William Bourguet is affiliated with the University of Montpellier in France and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology. Their research primarily focuses on Molecular Biology, Genetics, Health, Toxicology and Mutagenesis, Physiology, and Cell Biology.

The main topics covered in their work include:

  • Estrogen and related hormone effects
  • Retinoids in leukemia and cellular processes
  • Effects and risks of endocrine disrupting chemicals
  • Peroxisome Proliferator-Activated Receptors
  • Toxic Organic Pollutants Impact
  • Receptor Mechanisms and Signaling
  • Adipose Tissue and Metabolism

William Bourguet's recent papers encompass a variety of research themes. Notable publications include:

  • "Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex," 2022, published in Nature Communications
  • "Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures," 2020, published in Proceedings of the National Academy of Sciences
  • "The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds," 2020, published in International Journal of Molecular Sciences
  • "Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals," 2021, published in Environmental Science & Technology
  • "Structural and Functional Specialization of OSBP-Related Proteins," 2020, published in Contact

The frequent co-authors collaborating with William Bourguet are:

  • Patrick Balaguer
  • Marina Grimaldi
  • V. Delfosse
  • Coralie Carivenc
  • Albane le Maire

William Bourguet has published regularly in several scientific venues. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Environmental Science & Technology
  • Journal of Molecular Biology
  • Frontiers in Toxicology

Best Publications

  • Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

    William Bourguet;Marc Ruff;Pierre Chambon;Hinrich Gronemeyer

  • A canonical structure for the ligand-binding domain of nuclear receptors.

    Jean Marie Wurtz;William Bourguet;Jean Paul Renaud;Valerie Vivat

  • Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

    William Bourguet;Pierre Germain;Hinrich Gronemeyer

  • Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.

    William Bourguet;Valérie Vivat;Jean-Marie Wurtz;Pierre Chambon

  • Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

    Maud de Saint-Jean;Vanessa Delfosse;Dominique Douguet;Gaëtan Chicanne

  • Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.

    Vanessa Delfosse;Marina Grimaldi;Jean-Luc Pons;Abdelhay Boulahtouf

  • Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

    Joachim Moser von Filseck;Alenka Čopič;Vanessa Delfosse;Vanessa Delfosse;Stefano Vanni

  • Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.

    Holger Greschik;Jean-Marie Wurtz;Sarah Sanglier;William Bourguet

  • Design of selective nuclear receptor modulators: RAR and RXR as a case study

    Angel R de Lera;William Bourguet;William Bourguet;Lucia Altucci;Hinrich Gronemeyer

  • Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.

    Anne Riu;Marina Grimaldi;Albane le Maire;Gilbert Bey

  • Activation of RXR–PPAR heterodimers by organotin environmental endocrine disruptors

    Albane le Maire;Albane le Maire;Marina Grimaldi;Dominique Roecklin;Sonia Dagnino

  • Exploring hydrophobic sites in proteins with xenon or krypton.

    Thierry Prangé;Marc Schiltz;Lucile Pernot;Nathalie Colloc'h

  • Modulation of RXR function through ligand design.

    Efrén Pérez;William Bourguet;Hinrich Gronemeyer;Angel R. de Lera

  • Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

    Vivian Pogenberg;Jean-François Guichou;Valérie Vivat-Hannah;Sabrina Kammerer

  • A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

    Albane le Maire;Catherine Teyssier;Catherine Teyssier;Cathie Erb;Marina Grimaldi

  • Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

    Vanessa Delfosse;Vanessa Delfosse;Vanessa Delfosse;Béatrice Dendele;Tiphaine Huet;Tiphaine Huet;Tiphaine Huet;Marina Grimaldi

  • Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

    Virginie Nahoum;Efrén Pérez;Pierre Germain;Fátima Rodríguez-Barrios

  • Characterization of Novel Ligands of ERα, Erβ, and PPARγ: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites

    Anne Riu;Albane le Maire;Marina Grimaldi;Marc Audebert

  • A MUTATION MIMICKING LIGAND-INDUCED CONFORMATIONAL CHANGE YIELDS A CONSTITUTIVE RXR THAT SENSES ALLOSTERIC EFFECTS IN HETERODIMERS

    Valerie Vivat;Christina Zechel;Jean‐Marie Wurtz;William Bourguet

  • Estrogen-related receptor γ is an in vivo receptor of bisphenol A

    Marie Tohmé;Sophie M. Prud'homme;Abdel Boulahtouf;Eric Samarut

Frequent Co-Authors

Patrick Balaguer
Patrick Balaguer University of Montpellier
Hinrich Gronemeyer
Hinrich Gronemeyer Institute of Genetics and Molecular and Cellular Biology
Angel R. de Lera
Angel R. de Lera Universidade de Vigo
Dino Moras
Dino Moras Institute of Genetics and Molecular and Cellular Biology
Gilles Labesse
Gilles Labesse Grenoble Alpes University
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Catherine A. Royer
Catherine A. Royer Rensselaer Polytechnic Institute
Vincent Cavaillès
Vincent Cavaillès Institute of Cancer Research of Montpellier
Pau Bernadó
Pau Bernadó University of Montpellier
Vincent Laudet
Vincent Laudet Okinawa Institute of Science and Technology

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