World's Best Scientists 2026 revealed!
Xiao-kun Zhang

Xiao-kun Zhang

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Biology and Biochemistry
China
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
16863
World Ranking
6700
National Ranking
209

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Xiao-kun Zhang is affiliated with Xiamen University in China and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work primarily spans several subfields including molecular biology, cellular and molecular neuroscience, pharmacology, cognitive neuroscience, and ocean engineering.

The scientist's research covers a range of topics with a focus on nuclear receptors and signaling, microbial natural products and biosynthesis, neurobiology of language and bilingualism, retinoids in leukemia and cellular processes, synthesis of tetrazole derivatives, RNA interference and gene delivery, and microtubule and mitosis dynamics.

Frequent coauthors in Zhang's publications include:

  • Zhiping Zeng
  • Ying Su
  • Hu Zhou
  • Xiaohong Chen
  • Guobin Xie

Zhang has published in several journals repeatedly, with the most frequent venues being:

  • Acta Pharmaceutica Sinica B
  • Bioorganic Chemistry
  • Nature Communications
  • Angewandte Chemie International Edition
  • European Journal of Medicinal Chemistry

Notable recent papers authored or coauthored by Zhang include:

  • Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates, 2021, Nature Communications
  • Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis, 2021, Nature Communications
  • Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect, 2021, Chinese Chemical Letters
  • Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts, 2023, Cancer Letters
  • Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER to inhibit RANKL signaling, 2020, Acta Pharmaceutica Sinica B

Best Publications

  • Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.

    Xiao-kun Zhang;Birgit Hoffmann;Paul B.-V. Tran;Gerhart Graupner

  • Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

    Hui Li;Siva Kumar Kolluri;Jian Gu;Marcia I. Dawson

  • Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.

    Xiao-kun Zhang;Jürgen Lehmann;Birgit Hoffmann;Marcia I. Dawson;Marcia I. Dawson

  • Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

    Bingzhen Lin;Siva Kumar Kolluri;Feng Lin;Wen Liu

  • Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells.

    Yi Liu;Mi-Ock Lee;Hong-Gang Wang;Yin Li

  • Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

    Gerhart Graupner;Ken N. Wills;Maty Tzukerman;Xiao-kun Zhang

  • A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter

    Birgit Hoffmann;Jürgen M. Lehmann;Xiao-kun Zhang;Thomas Hermann

  • Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

    Mengjie Hu;Qiang Luo;Gulimiran Alitongbieke;Shuyi Chong

  • COUP orphan receptors are negative regulators of retinoic acid response pathways.

    P. Tran;Xiao-Kun Zhang;G. Salbert;T. Hermann

  • p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction.

    Moll Um;Marchenko N;Zhang Xk

  • Retinoid X Receptor Regulates Nur77/Thyroid Hormone Receptor 3-Dependent Apoptosis by Modulating Its Nuclear Export and Mitochondrial Targeting

    Xihua Cao;Wen Liu;Feng Lin;Hui Li

  • A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

    Siva Kumar Kolluri;Xiuwen Zhu;Xin Zhou;Bingzhen Lin

  • Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.

    Siva Kumar Kolluri;Nathalie Bruey-Sedano;Xihua Cao;Bingzhen Lin

  • Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein–methyltransferase superfamily

    George Steele-Perkins;George Steele-Perkins;Wei Fang;Xiao Hong Yang;Mireille Van Gele

  • Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities.

    Xiao-Kun Zhang;K. N. Wills;M. Husmann;T. Hermann

  • Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

    Yin Li;Bingzhen Lin;Anissa Agadir;Ru Liu

  • Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.

    Yang-Yen Hf;Zhang Xk;Graupner G;Tzukerman M

  • Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization

    Qiao Wu;Yin Li;Ru Liu;Anissa Agadir

  • Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt

    Han Yh;Cao X;Lin B;Lin F

  • Interaction of BAG-1 with Retinoic Acid Receptor and Its Inhibition of Retinoic Acid-induced Apoptosis in Cancer Cells*

    Ru Liu;Shinichi Takayama;Yun Zheng;Barbara Froesch

Frequent Co-Authors

Marcia I. Dawson
Marcia I. Dawson Sanford Burnham Prebys Medical Discovery Institute
Magnus Pfahl
Magnus Pfahl National Foundation for Cancer Research
John C. Reed
John C. Reed Johnson & Johnson (United States)
Jie Liu
Jie Liu Duke University
Mark Leid
Mark Leid Oregon State University
Mingyu Li
Mingyu Li Harbin Institute of Technology
Xin-Sheng Yao
Xin-Sheng Yao Jinan University
Nemani V. Prasadarao
Nemani V. Prasadarao University of Southern California
Pei-Qiang Huang
Pei-Qiang Huang Xiamen University
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center

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