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Peter M. Siegel

Peter M. Siegel

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
28206
World Ranking
8050
National Ranking
280

Overview

Peter M. Siegel is affiliated with McGill University in Canada. Their research spans multiple areas within the life sciences, focusing heavily on molecular biology, oncology, and immunology. The scientist's work is primarily situated within the broader fields of biochemistry, genetics, and molecular biology, as well as medicine.

The specific subfields of study Peter M. Siegel engages in include molecular biology, pulmonary and respiratory medicine, cancer research, oncology, and immunology. These areas reflect a multidisciplinary approach to understanding cancer biology and immune mechanisms at the cellular and molecular levels.

The research topics covered by their publications highlight significant interest in multiple aspects of cancer biology and treatment:

  • Brain Metastases and Treatment
  • Cancer, Hypoxia, and Metabolism
  • Ferroptosis and cancer prognosis
  • Immune cells in cancer
  • Metabolism, Diabetes, and Cancer
  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics

Peter M. Siegel has contributed to research published in numerous scientific journals, with a notable presence in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Neuro-Oncology Advances

Frequent co-authors working with Peter M. Siegel include:

  • Matthew G. Annis
  • Matthew Dankner
  • Morag Park
  • Kevin Petrecca
  • Sarah M. Maritan

Among their recent publications, several papers stand out for their contributions to our understanding of cancer and immune microenvironments:

  • Single-cell spatial landscapes of the lung tumour immune microenvironment, 2023, Nature
  • Single-cell spatial immune landscapes of primary and metastatic brain tumours, 2023, Nature
  • AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3, 2021, Autophagy
  • The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer, 2023, Immunity
  • Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer, 2021, Cell Metabolism

Best Publications

  • Genes that mediate breast cancer metastasis to lung

    Andy J. Minn;Gaorav P. Gupta;Peter M. Siegel;Peter M. Siegel;Paula D. Bos

  • A multigenic program mediating breast cancer metastasis to bone.

    Yibin Kang;Peter M. Siegel;Weiping Shu;Maria Drobnjak

  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Jeremy Schwartzentruber;Andrey Korshunov;Xiao Yang Liu;David T.W. Jones

  • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.

    Peter M. Siegel;Joan Massagué

  • AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

    Brandon Faubert;Gino Boily;Said Izreig;Takla Griss

  • E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

    Chang Rung Chen;Yibin Kang;Peter M. Siegel;Joan Massagué

  • Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.

    Peter M. Siegel;Eamonn D. Ryan;Robert D. Cardiff;William J. Muller

  • Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

    Peter M. Siegel;Weiping Shu;Robert D. Cardiff;William J. Muller

  • PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

    Fanny Dupuy;Sébastien Tabariès;Sylvia Andrzejewski;Zhifeng Dong

  • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations.

    Xiao-Yang Liu;Noha Gerges;Andrey Korshunov;Nesrin Sabha

  • Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

    Adam M. Fontebasso;Simon Papillon-Cavanagh;Jeremy Schwartzentruber;Hamid Nikbakht

  • Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations.

    Matthew Dankner;April A N Rose;Shivshankari Rajkumar;Peter M Siegel

  • Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.

    Richard J. Lee;Chris Albanese;Maofu Fu;Mark D'Amico

  • Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

    Eran R. Andrechek;William R. Hardy;Peter M. Siegel;Michael A. Rudnicki

  • Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

    S K Muthuswamy;P M Siegel;D L Dankort;M A Webster

  • Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis.

    Camille Lehuédé;Fanny Dupuy;Rebecca Rabinovitch;Russell G. Jones

  • Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

    P M Siegel;D L Dankort;W R Hardy;W J Muller

  • Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo IMPLICATIONS FOR HUMAN BREAST CANCER

    Jeffrey A. Engelman;Richard J. Lee;Anthony Karnezis;David J. Bearss

  • ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.

    April A. N. Rose;Matthew G. Annis;Zhifeng Dong;Francois Pepin

  • Osteoactivin promotes breast cancer metastasis to bone.

    April A.N. Rose;François Pepin;Caterina Russo;Jad E. Abou Khalil

Frequent Co-Authors

William J. Muller
William J. Muller McGill University
Morag Park
Morag Park McGill University
Russell G. Jones
Russell G. Jones McGill University
Julie St-Pierre
Julie St-Pierre McGill University
Joan Massagué
Joan Massagué Memorial Sloan Kettering Cancer Center
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Wilson H. Miller
Wilson H. Miller McGill University
David T. W. Jones
David T. W. Jones German Cancer Research Center
Nada Jabado
Nada Jabado McGill University
Jeremy Schwartzentruber
Jeremy Schwartzentruber Wellcome Sanger Institute

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