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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
37766
World Ranking
10505
National Ranking
4557

Overview

Lambertus Klei is affiliated with the University of Pittsburgh in the United States and is active in research areas spanning biochemistry, genetics, molecular biology, and neuroscience. Their work primarily focuses on genetics and cognitive neuroscience, with contributions to molecular biology and clinical psychology. Epidemiology also features as a subfield in their research portfolio.

The scientist's research includes an emphasis on autism spectrum disorder, genetic associations, epidemiology, and obsessive-compulsive spectrum disorders. Their investigations cover genomic variations, chromosomal abnormalities, bioinformatics, genomic networks, gene expression, cancer classification, and neurodevelopmental disorders.

Lambertus Klei has published extensively in various venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature Genetics
  • Molecular Autism
  • Translational Psychiatry

Their frequent collaborators include Bernie Devlin, Joseph D. Buxbaum, Kathryn Roeder, Behrang Mahjani, and Christina M. Hultman.

Recent papers highlighting the scientist's work include:

  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism (2020, Cell)
  • Rare coding variation provides insight into the genetic architecture and phenotypic context of autism (2022, Nature Genetics)
  • Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020, Scientific Data)
  • Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex (2020, Cell Reports)
  • Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease (2021, Molecular Psychiatry)

Best Publications

  • Synaptic, transcriptional and chromatin genes disrupted in autism

    Silvia De Rubeis;Xin-Xin He;Arthur P Goldberg;Christopher S. Poultney

  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

    S. Hong Lee;Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Stephen V. Faraone

  • Functional impact of global rare copy number variation in autism spectrum disorders

    Dalila Pinto;Alistair T. Pagnamenta;Lambertus Klei;Richard Anney

  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

    F. Kyle Satterstrom;F. Kyle Satterstrom;Jack A. Kosmicki;Jiebiao Wang;Michael S. Breen

  • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

    Joseph T. Glessner;Kai Wang;Guiqing Cai;Olena Korvatska

  • Mapping autism risk loci using genetic linkage and chromosomal rearrangements

    Peter Szatmari;Andrew D. Paterson;Lonnie Zwaigenbaum;Wendy Roberts

  • Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

    Stephan J. Sanders;Xin He;A. Jeremy Willsey;A. Gulhan Ercan-Sencicek

  • Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

    Stephan J. Sanders;A. Gulhan Ercan-Sencicek;Vanessa Hus;Rui Luo

  • Most genetic risk for autism resides with common variation

    Trent Gaugler;Lambertus Klei;Stephan J. Sanders;Corneliu A. Bodea

  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Phil H. Lee;Verneri Anttila;Hyejung Won;Yen-Chen A. Feng

  • Gene expression elucidates functional impact of polygenic risk for schizophrenia

    Menachem Fromer;Panos Roussos;Solveig K. Sieberts;Jessica S. Johnson

  • Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

    Dalila Pinto;Elsa Delaby;Elsa Delaby;Elsa Delaby;Daniele Merico;Mafalda Barbosa

  • Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

    A. Jeremy Willsey;A. Jeremy Willsey;Stephan J. Sanders;Stephan J. Sanders;Mingfeng Li;Shan Dong;Shan Dong

  • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

    Richard J.L. Anney;Richard J.L. Anney;Stephan Ripke;Stephan Ripke;Stephan Ripke;Verneri Anttila;Jakob Grove;Jakob Grove

  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    Colm O'Dushlaine;Lizzy Rossin;Phil H. Lee;Laramie Duncan;Laramie Duncan

  • A genome-wide scan for common alleles affecting risk for autism

    Richard Anney;Lambertus Klei;Dalila Pinto;Regina Regan

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

    F. Kyle Satterstrom;Jack A. Kosmicki;Jiebiao Wang;Michael S Breen;Michael S Breen

  • Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

    Lee Ph;Anttila;Won H

  • Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

    Dalila Pinto;Elsa Delaby;Daniele Merico;Mafalda Barbosa

Frequent Co-Authors

Bernie Devlin
Bernie Devlin University of Pittsburgh
Kathryn Roeder
Kathryn Roeder Carnegie Mellon University
Joseph D. Buxbaum
Joseph D. Buxbaum Icahn School of Medicine at Mount Sinai
Matthew W. State
Matthew W. State University of California, San Francisco
Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles
Edwin H. Cook
Edwin H. Cook University of Illinois at Chicago
Benjamin M. Neale
Benjamin M. Neale Harvard University
Catalina Betancur
Catalina Betancur Sorbonne University
James S. Sutcliffe
James S. Sutcliffe Vanderbilt University

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