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Philippe Clézardin

Philippe Clézardin

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
14841
World Ranking
7133
National Ranking
231

Overview

Philippe Clézardin is affiliated with Inserm in France and has contributed extensively to research in medicine, biochemistry, genetics, and molecular biology. Their work predominantly focuses on oncology and cancer research, with specific attention to bone health and metastatic bone disease.

The primary topics of their research include:

  • Bone health and treatments
  • Management of metastatic bone disease
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Cancer-related molecular mechanisms research
  • Cancer diagnosis and treatment
  • Cancer cells and metastasis

Frequent coauthors collaborating with Philippe Clézardin are:

  • Martine Croset
  • Edith Bonnelye
  • Margherita Puppo
  • Cyrille B. Confavreux
  • Lamia Bouazza

Their research has been published mainly in:

  • Cancers
  • Frontiers in Oncology
  • Journal of Bone Oncology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Revue du Rhumatisme

Recent notable publications include:

  • "Bone metastasis: mechanisms, therapies, and biomarkers" (2020), Physiological Reviews
  • "Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions" (2021), Oncogene
  • "Fracture Risk Evaluation of Bone Metastases: A Burning Issue" (2021), Cancers

Other significant works relevant to their field include:

  • "Bone metastases" (2020), Nature Reviews Disease Primers
  • "The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases" (2020), Frontiers in Oncology

Philippe Clézardin's contributions reflect a broad interest in molecular biology aspects related to cancer, including the regulatory roles of microRNAs and circular RNAs in disease processes. Their research spans clinical and molecular investigations aimed at understanding the mechanisms underlying bone metastases and potential therapeutic targets.

Best Publications

  • Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.

    Sandrine Boissier;Mercedes Ferreras;Olivier Peyruchaud;Sandrine Magnetto

  • Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

    Ahmed Boucharaba;Claire-Marie Serre;Sandra Grès;Jean Sébastien Saulnier-Blache

  • Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices

    Sandrine Boissier;Sandrine Magnetto;Lucien Frappart;Béatrice Cuzin

  • SiRNA-mediated Inhibition of Vascular Endothelial Growth Factor Severely Limits Tumor Resistance to Antiangiogenic Thrombospondin-1 and Slows Tumor Vascularization and Growth

    Stéphanie Filleur;Aurélie Courtin;Slimane Ait-Si-Ali;Julien Guglielmi

  • Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

    Isabelle Pecheur;Olivier Peyruchaud;Claire-Marie Serre;Julien Guglielmi

  • Bisphosphonates and Cancer-Induced Bone Disease: Beyond Their Antiresorptive Activity

    Philippe Clézardin;Frank H. Ebetino;Pierrick G.J. Fournier

  • The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases

    Ahmed Boucharaba;Claire-Marie Serre;Julien Guglielmi;Jean-Claude Bordet

  • Bone metastasis: mechanisms, therapies, and biomarkers.

    Philippe Clézardin;Philippe Clézardin;Rob Coleman;Margherita Puppo;Penelope Ottewell

  • Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases

    Yingshe Zhao;Richard Bachelier;Isabelle Treilleux;Philippe Pujuguet

  • Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions.

    Olivier Peyruchaud;Bent Winding;Isabelle Pécheur;Claire-Marie Serre

  • Bisphosphonates in cancer therapy.

    Verena Stresing;Florence Daubiné;Florence Daubiné;Ismahène Benzaid;Ismahène Benzaid;Hannu Mönkkönen;Hannu Mönkkönen

  • Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

    Jeroen T. Buijs;Nico V. Henriquez;Petra G.M. van Overveld;Geertje van der Horst

  • A Cathepsin K Inhibitor Reduces Breast Cancer–Induced Osteolysis and Skeletal Tumor Burden

    Céline Le Gall;Akeila Bellahcène;Edith Bonnelye;Jürg A. Gasser

  • Direct and indirect anticancer activity of bisphosphonates: A brief review of published literature

    Michael Gnant;Philippe Clézardin

  • Effects of Bone-Targeted Agents on Cancer Progression and Mortality

    Robert Coleman;Michael Gnant;Gareth Morgan;Philippe Clezardin

  • Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients.

    Daniele Santini;Gaia Schiavon;Gaia Schiavon;Bruno Vincenzi;Laura Maria Gaeta

  • Bisphosphonates' antitumor activity: An unravelled side of a multifaceted drug class

    Philippe Clézardin

  • Increased Dickkopf-1 expression in breast cancer bone metastases

    Nathalie Voorzanger-Rousselot;Delphine Goehrig;Delphine Goehrig;Fabrice Journé;Valérie Doriath

  • The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth

    Floriane Pez;Frédéric Dayan;Jérome Durivault;Bastien Kaniewski

  • Adjuvant bisphosphonates in early breast cancer: Consensus guidance for clinical practice from a European Panel

    P. Hadji;Robert E. Coleman;C. Wilson;T. J. Powles

Frequent Co-Authors

Serge Ferrari
Serge Ferrari University of Geneva
Toshio Matsumoto
Toshio Matsumoto University of Tokushima
Ego Seeman
Ego Seeman University of Melbourne
David Karasik
David Karasik Bar-Ilan University
Kenneth J. Clemetson
Kenneth J. Clemetson University of Bern
Robert E. Coleman
Robert E. Coleman University of Sheffield
Daniele Santini
Daniele Santini Università Campus Bio-Medico
Jack Lawler
Jack Lawler Beth Israel Deaconess Medical Center

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