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Immunology

D-Index
48
Citations
9296
World Ranking
4423
National Ranking
2007

Overview

Edith M. Lord is affiliated with the University of Rochester Medical Center in the United States. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with a substantive body of work related to Oncology, Immunology, and Surgery. The scientist's work encompasses various topics centered around cancer immunotherapy and biomarkers, immune cells in cancer, and immunotherapy and immune responses.

The main topics covered by their research include:

  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Cancer, Stress, Anesthesia, and Immune Response
  • Cancer Cells and Metastasis
  • CAR-T cell therapy research

Frequent co-authors in Edith M. Lord's collaborations include:

  • David C. Linehan
  • Bradley N. Mills
  • Scott A. Gerber
  • Taylor P. Uccello
  • Joseph D. Murphy

The scientist often publishes in several key venues:

  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal for ImmunoTherapy of Cancer
  • International Journal of Radiation Oncology*Biology*Physics
  • Cancers

Notable recent papers by Edith M. Lord include:

  • "Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer," 2022, Journal for ImmunoTherapy of Cancer
  • "Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors," 2022, The Journal of Immunology
  • "CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models," 2023, Journal for ImmunoTherapy of Cancer
  • "Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma," 2020, Immunological Investigations
  • "Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity," 2022, International Journal of Molecular Sciences

The research output reflects a consistent engagement with cancer immunotherapy, exploring mechanisms and therapeutic strategies that engage immune cell functions and tumor microenvironments. Their work addresses challenges in radiotherapy resistance and investigates novel immunotherapeutic combinations aimed at improving treatment efficacy.

Best Publications

  • Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

    Amit A. Lugade;James P. Moran;Scott A. Gerber;Robert C. Rose

  • Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity

    Amit A. Lugade;Elizabeth W. Sorensen;Scott A. Gerber;James P. Moran

  • Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

    Shani Bialik;David L. Geenen;Isaac E. Sasson;Rendi Cheng

  • Detection of Hypoxic Cells by Monoclonal Antibody Recognizing 2-Nitroimidazole Adducts

    Edith M. Lord;Lee Harwell;Cameron J. Koch

  • Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells.

    Joanne Y. H. Lim;Scott A. Gerber;Shawn P. Murphy;Edith M. Lord

  • Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.

    C. J. Koch;S. M. Evans;E. M. Lord

  • Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding

    Sydney M. Evans;Stephen Hahn;Deirdre R. Pook;W. Timothy Jenkins

  • Preferential Attachment of Peritoneal Tumor Metastases to Omental Immune Aggregates and Possible Role of a Unique Vascular Microenvironment in Metastatic Survival and Growth

    Scott A. Gerber;Viktoriya Y. Rybalko;Chad E. Bigelow;Amit A. Lugade

  • Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation.

    Edith M. Lord;George F. Sensabaugh;Daniel P. Stites

  • Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle.

    Yin Chang Liu;Robert L. Marraccino;Peter C. Keng;Robert A. Bambara

  • Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia, and gestation.

    Ronald I Clyman;Cecilia Y Chan;Françoise Mauray;Yao Qi Chen

  • Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide].

    S. M. Evans;B. Joiner;W. T. Jenkins;K. M. Laughlin

  • Imaging of Vascular Development in Early Mouse Decidua and Its Association with Leukocytes and Trophoblasts

    B. Anne Croy;Zhilin Chen;Alexander P. Hofmann;Edith M. Lord

  • IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor.

    Scott A. Gerber;Abigail L. Sedlacek;Kyle R. Cron;Shawn P. Murphy

  • 2-Nitroimidazole (EF5) Binding Predicts Radiation Resistance in Individual 9L s.c. Tumors

    S M Evans;W T Jenkins;B Joiner;E M Lord

  • Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1.

    S. M. Evans;A. V. Kachur;C. Y. Shiue;Roland Hustinx

  • Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.

    Wei C;Willis Ra;Tilton Br;Looney Rj

  • Functional Heterogeneity among the T-Derived Lymphocytes of the Mouse I. Analysis by Adult Thymectomy

    John W. Kappler;Philippa C. Hunter;Diane Jacobs;Edith Lord

  • Human Papillomavirus Virus-Like Particles Are Efficient Oral Immunogens when Coadministered with Escherichia coli Heat-Labile Enterotoxin Mutant R192G or CpG DNA

    S. Gerber;C. Lane;Deborah M. Brown;E. Lord

  • Optogenetic control of chemokine receptor signal and T-cell migration

    Yuexin Xu;Young-Min Hyun;Kihong Lim;Hyunwook Lee

  • Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements.

    B M Fenton;S F Paoni;J Lee;C J Koch

  • Tumours can act as adjuvants for humoral immunity.

    D. M. Brown;T. L. Fisher;C. Wei;J. G. Frelinger

  • Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker

    Nahid S. Waleh;Michael D. Brody;Merrill A. Knapp;Holly L. Mendonca

  • Hypoxia-mediated Apoptosis from Angiogenesis Inhibition Underlies Tumor Control by Recombinant Interleukin 12

    Michael S. Gee;Cameron J. Koch;Sydney M. Evans;W. Timothy Jenkins

Frequent Co-Authors

Scott A. Gerber
Scott A. Gerber Dartmouth College
Cameron J. Koch
Cameron J. Koch University of Pennsylvania
Peter C. Keng
Peter C. Keng University of Rochester
Robert A. Bambara
Robert A. Bambara University of Rochester
Jeffrey A. Frelinger
Jeffrey A. Frelinger University of Arizona
John W. Kappler
John W. Kappler National Jewish Health
William J. Bowers
William J. Bowers University of Rochester
Howard J. Federoff
Howard J. Federoff University of California, Irvine
Donna M. Ferriero
Donna M. Ferriero University of California, San Francisco
Philippa Marrack
Philippa Marrack National Jewish Health

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