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Niels H. Gehring

Niels H. Gehring

D-Index & Metrics

Genetics

D-Index
44
Citations
6983
World Ranking
4264
National Ranking
286

Overview

Niels H. Gehring is affiliated with the University of Cologne in Germany and has contributed significantly to the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as the core subfield of expertise. Their work spans other areas such as Cardiology and Cardiovascular Medicine, Oncology, Cell Biology, and Cancer Research.

The main research topics addressed by Gehring include RNA Research and Splicing, RNA and protein synthesis mechanisms, and RNA modifications related to cancer. Additional topics of interest encompass Viral Infections and Immunology Research, Endoplasmic Reticulum Stress and Disease, Single-cell and spatial transcriptomics, and Cancer Genomics and Diagnostics.

Gehring's frequent coauthors illustrate close collaborative relationships with several scientists, including Volker Boehm, Christoph Dieterich, Janine Altmüller, Thiago Britto-Borges, and Sabrina Kueckelmann.

Publication outlets for Gehring's work reflect the scientific communities and research areas engaged, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Nucleic Acids Research, RNA, and Trends in Genetics.

Recent published papers authored or coauthored by Gehring include:

  • Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation, 2020, Trends in Genetics
  • A Day in the Life of the Exon Junction Complex, 2020, Biomolecules
  • SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity, 2021, Nature Communications
  • CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex, 2020, Nucleic Acids Research
  • Human UPF3A and UPF3B enable fault-tolerant activation of nonsense-mediated mRNA decay, 2022, The EMBO Journal

Best Publications

  • Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

    Ute Schaeper;Niels H. Gehring;Klaus P. Fuchs;Martin Sachs

  • Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.

    Pavel V Ivanov;Niels H Gehring;Niels H Gehring;Joachim B Kunz;Joachim B Kunz;Matthias W Hentze

  • Exon-Junction Complex Components Specify Distinct Routes of Nonsense-Mediated mRNA Decay with Differential Cofactor Requirements

    Niels H. Gehring;Joachim B. Kunz;Joachim B. Kunz;Gabriele Neu-Yilik;Gabriele Neu-Yilik;Stephen Breit

  • Y14 and hUpf3b form an NMD-activating complex.

    Niels H. Gehring;Gabriele Neu-Yilik;Gabriele Neu-Yilik;Thomas Schell;Matthias W. Hentze

  • Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia.

    Niels H. Gehring;Ute Frede;Gabriele Neu-Yilik;Patrick Hundsdoerfer

  • Disassembly of Exon Junction Complexes by PYM

    Niels H. Gehring;Niels H. Gehring;Styliani Lamprinaki;Andreas E. Kulozik;Andreas E. Kulozik;Matthias W. Hentze

  • Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation

    Niels H. Gehring;Elmar Wahle;Utz Fischer

  • Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2.

    Marcello Clerici;André Mourão;Irina Gutsche;Niels H Gehring;Niels H Gehring

  • Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

    Joachim B. Kunz;Gabriele Neu-Yilik;Matthias W. Hentze;Andreas E. Kulozik

  • Using the lambdaN peptide to tether proteins to RNAs.

    Julie Baron-Benhamou;Niels H. Gehring;Andreas E. Kulozik;Matthias W. Hentze

  • Mechanism of escape from nonsense-mediated mRNA decay of human β-globin transcripts with nonsense mutations in the first exon

    Gabriele Neu-Yilik;Beate Amthor;Niels H. Gehring;Sharif Bahri

  • The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

    Niels H. Gehring;Styliani Lamprinaki;Matthias W. Hentze;Andreas E. Kulozik;Andreas E. Kulozik

  • The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

    Marc Lewitzky;Christian Kardinal;Niels H Gehring;Enrico K Schmidt

  • Exon Junction Complexes: Supervising the Gene Expression Assembly Line

    Volker Boehm;Niels H. Gehring

  • The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

    Marcelo H. Viegas;Niels H. Gehring;Stephen Breit;Matthias W. Hentze

  • IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1)

    Ulf-Peter Guenther;Lusy Handoko;Bernhard Laggerbauer;Sibylle Jablonka

  • CWC22 connects pre-mRNA splicing and exon junction complex assembly.

    Anna-Lena Steckelberg;Volker Boehm;Agnieszka M. Gromadzka;Niels H. Gehring

  • Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation.

    Lara Ajamian;Levon Abrahamyan;Miroslav Milev;Pavel V. Ivanov

  • The human intronless melanocortin 4-receptor gene is NMD insensitive

    Katja S. Brocke;Gabriele Neu-Yilik;Niels H. Gehring;Matthias W. Hentze

  • Assembly, disassembly and recycling: the dynamics of exon junction complexes.

    Fulvia Bono;Niels H Gehring

Frequent Co-Authors

Andreas E. Kulozik
Andreas E. Kulozik Heidelberg University
Matthias W. Hentze
Matthias W. Hentze European Molecular Biology Laboratory
Christoph Dieterich
Christoph Dieterich University Hospital Heidelberg
Janine Altmüller
Janine Altmüller University of Cologne
Utz Fischer
Utz Fischer University of Würzburg
Fabio Benfenati
Fabio Benfenati Italian Institute of Technology
Andrew J. Mouland
Andrew J. Mouland McGill University
Kay Hofmann
Kay Hofmann University of Cologne
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
Pavel Ivanov
Pavel Ivanov Brigham and Women's Hospital

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